130-10051-100

antibody from RayBiotech, Inc.

Targeting: CDKN1A CAP20, CDKN1, CIP1, P21, p21CIP1, p21Cip1/Waf1, SDI1, WAF1

ELISA (Recommended by provider)

Antibody Data

Product number

130-10051-100

Provider

RayBiotech, Inc.

Product name

Rabbit Anti-Human p21

Antibody type

Polyclonal

Antigen

Synthetic peptide derived from human p21.

Description

The encode protein of p21 is the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. p21 binds to and inhibits cyclindependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions of p21 in the nuclear localization and assembly of cyclin D-CDK4 complex, promotes its kinase activity towards RB1. At higher stoichiometric ratios, p21 inhibits the kinase activity of the cyclin D-CDK4 complex. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum by ammonium sulphate precipitation, and followed by Protein A/G affinity chromatography.

Reactivity

Human

Host

Rabbit

Antigen sequence

This antibody was produced from a r
abbit immunized with the immunogen.
The IgG fraction was purified from
rabbit serum by ammonium sulphate
precipitation, and followed by Prot
ein A/G affinity chromatography.


Isotype

IgG

Vial size

100 µg

Handling

Supplied as lyophilized and purified antibody originally containing PBS, without Preservative Stabilizers, such as Sodium Azide. The final concentration is indicated on the shipping vial. The antibody is stable for at least years from the data of receipt when stored at -20°C to -70°C. Reconstituted antibody (suggesting with sterile PBS) can also be aliquotted and stored frozen at -20°C to -70°C in a manual defrost freezer for months without detectable loss activity. Upon reconstitution, the antibody can also be stored over months at 4°C. Please avoid freeze-thaw cycles.