60214-1-Ig
antibody from Proteintech Group
Targeting: CDKN1A
CAP20, CDKN1, CIP1, P21, p21CIP1, p21Cip1/Waf1, SDI1, WAF1
Antibody data
- Antibody Data
- Antigen structure
- References [18]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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Validation data
Reference
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- Product number
- 60214-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#60214-1-Ig, RRID:AB_11042450
- Product name
- P21 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated P21 antibody (Cat. #60214-1-Ig) is a mouse monoclonal antibody that shows reactivity with monkey and has been validated for the following applications: ELISA.
- Reactivity
- Simian
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 5F2F3
- Vial size
- 20ul, 150ul
Submitted references Discovery and Verification of Key Liver Cancer Genes and Alternative Splicing Events Based on Second-Generation Sequencing Data Analysis.
Therapeutic Potential of CUDC-907 (Fimepinostat) for Hepatocarcinoma Treatment Revealed by Tumor Spheroids-Based Drug Screening.
Rational design and synthesis of 6-aryl-6H-benzo[c]chromenes as non-steroidal progesterone receptor antagonists for use against cancers.
Cyanidin-3-O-glucoside inhibits epithelial-to-mesenchymal transition, and migration and invasion of breast cancer cells by upregulating KLF4.
S100A6 promotes proliferation and migration of HepG2 cells via increased ubiquitin-dependent degradation of p53.
GBP1 promotes erlotinib resistance via PGK1‑activated EMT signaling in non‑small cell lung cancer.
Bovine Milk Exosomes Affect Proliferation and Protect Macrophages against Cisplatin-Induced Cytotoxicity.
Combination of N, N'-dicyclohexyl-N-arachidonic acylurea and tacrolimus prolongs cardiac allograft survival in mice.
SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21CIPI , cyclin D1 and β-catenin.
CircRNA_014511 affects the radiosensitivity of bone marrow mesenchymal stem cells by binding to miR-29b-2-5p.
NFIB promotes cell survival by directly suppressing p21 transcription in TP53-mutated triple-negative breast cancer.
HOXC13-AS promotes breast cancer cell growth through regulating miR-497-5p/PTEN axis.
GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner.
Ginsenoside Rg1 ameliorates testicular senescence changes in D‑gal‑induced aging mice via anti‑inflammatory and antioxidative mechanisms.
MiRNA-20a-5p promotes the growth of triple-negative breast cancer cells through targeting RUNX3.
Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma.
GAS5 Inhibits Gastric Cancer Cell Proliferation Partly by Modulating CDK6.
Transgenic mice overexpressing glia maturation factor-β, an oxidative stress inducible gene, show premature aging due to Zmpste24 down-regulation.
Cui M, Bai M, Zheng L, Bao Y, Sun L, Yu C, Sun Y, Song Z, Wang G, Yu Z, Li Y, Huang Y
Biological & pharmaceutical bulletin 2021;44(10):1433-1444
Biological & pharmaceutical bulletin 2021;44(10):1433-1444
Therapeutic Potential of CUDC-907 (Fimepinostat) for Hepatocarcinoma Treatment Revealed by Tumor Spheroids-Based Drug Screening.
Liao W, Yang W, Xu J, Yan Z, Pan M, Xu X, Zhou S, Zhu Y, Lan J, Zeng M, Han X, Li S, Li Y, Liang K, Gao Y, Peng Q
Frontiers in pharmacology 2021;12:658197
Frontiers in pharmacology 2021;12:658197
Rational design and synthesis of 6-aryl-6H-benzo[c]chromenes as non-steroidal progesterone receptor antagonists for use against cancers.
Qin J, Qu S, Zhu K, Cheng Y, Pan G, Jing W, Liu X, Sun X, Liu L
Bioorganic & medicinal chemistry 2021 Feb 15;32:116003
Bioorganic & medicinal chemistry 2021 Feb 15;32:116003
Cyanidin-3-O-glucoside inhibits epithelial-to-mesenchymal transition, and migration and invasion of breast cancer cells by upregulating KLF4.
Chen D, Yuan M, Ye Q, Wang X, Xu J, Shi G, Hu Z
Food & nutrition research 2020;64
Food & nutrition research 2020;64
S100A6 promotes proliferation and migration of HepG2 cells via increased ubiquitin-dependent degradation of p53.
Song D, Xu B, Shi D, Li S, Cai Y
Open medicine (Warsaw, Poland) 2020;15(1):317-326
Open medicine (Warsaw, Poland) 2020;15(1):317-326
GBP1 promotes erlotinib resistance via PGK1‑activated EMT signaling in non‑small cell lung cancer.
Cheng L, Gou L, Wei T, Zhang J
International journal of oncology 2020 Sep;57(3):858-870
International journal of oncology 2020 Sep;57(3):858-870
Bovine Milk Exosomes Affect Proliferation and Protect Macrophages against Cisplatin-Induced Cytotoxicity.
Matic S, D'Souza DH, Wu T, Pangloli P, Dia VP
Immunological investigations 2020 Oct;49(7):711-725
Immunological investigations 2020 Oct;49(7):711-725
Combination of N, N'-dicyclohexyl-N-arachidonic acylurea and tacrolimus prolongs cardiac allograft survival in mice.
An K, Qin Q, Yu S, Xue M, Wang Z, Lin Q, Ma Y, Yan G, Mo S, Chen Y, Zhang L, Zhong J, Qi Z, Xia J
Immunology and cell biology 2020 May;98(5):382-396
Immunology and cell biology 2020 May;98(5):382-396
SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21CIPI , cyclin D1 and β-catenin.
Lv L, Zhou M, Zhang J, Liu F, Qi L, Zhang S, Bi Y, Yu Y
FEBS open bio 2020 Jan;10(1):135-146
FEBS open bio 2020 Jan;10(1):135-146
CircRNA_014511 affects the radiosensitivity of bone marrow mesenchymal stem cells by binding to miR-29b-2-5p.
Wang Y, Zhang J, Li J, Gui R, Nie X, Huang R
Bosnian journal of basic medical sciences 2019 May 20;19(2):155-163
Bosnian journal of basic medical sciences 2019 May 20;19(2):155-163
NFIB promotes cell survival by directly suppressing p21 transcription in TP53-mutated triple-negative breast cancer.
Liu RZ, Vo TM, Jain S, Choi WS, Garcia E, Monckton EA, Mackey JR, Godbout R
The Journal of pathology 2019 Feb;247(2):186-198
The Journal of pathology 2019 Feb;247(2):186-198
HOXC13-AS promotes breast cancer cell growth through regulating miR-497-5p/PTEN axis.
Li X, Wang Q, Rui Y, Zhang C, Wang W, Gu J, Tang J, Ding Y
Journal of cellular physiology 2019 Dec;234(12):22343-22351
Journal of cellular physiology 2019 Dec;234(12):22343-22351
GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner.
Lin F, Xie YJ, Zhang XK, Huang TJ, Xu HF, Mei Y, Liang H, Hu H, Lin ST, Luo FF, Lang YH, Peng LX, Qian CN, Huang BJ
Journal of experimental & clinical cancer research : CR 2019 Apr 8;38(1):152
Journal of experimental & clinical cancer research : CR 2019 Apr 8;38(1):152
Ginsenoside Rg1 ameliorates testicular senescence changes in D‑gal‑induced aging mice via anti‑inflammatory and antioxidative mechanisms.
Wang ZL, Chen LB, Qiu Z, Chen XB, Liu Y, Li J, Wang L, Wang YP
Molecular medicine reports 2018 May;17(5):6269-6276
Molecular medicine reports 2018 May;17(5):6269-6276
MiRNA-20a-5p promotes the growth of triple-negative breast cancer cells through targeting RUNX3.
Bai X, Han G, Liu Y, Jiang H, He Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:1482-1489
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:1482-1489
Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma.
Zhao Y, Zhang B, Lei Y, Sun J, Zhang Y, Yang S, Zhang X
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct;37(10):13167-13176
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct;37(10):13167-13176
GAS5 Inhibits Gastric Cancer Cell Proliferation Partly by Modulating CDK6.
Guo X, Deng K, Wang H, Xia J, Shan T, Liang Z, Yao L, Jin S
Oncology research and treatment 2015;38(7-8):362-6
Oncology research and treatment 2015;38(7-8):362-6
Transgenic mice overexpressing glia maturation factor-β, an oxidative stress inducible gene, show premature aging due to Zmpste24 down-regulation.
Imai R, Asai K, Hanai J, Takenaka M
Aging 2015 Jul;7(7):486-99
Aging 2015 Jul;7(7):486-99
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 60214-1-Ig(P21 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using CDKN1A antibody 60214-1-lg at 1:50 dilution and Rhodamine-labeled goat anti-mouse IgG (red).
- Sample type
- cell line