Antibody data
- Antibody Data
- Antigen structure
- References [46]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 10197-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10197-1-AP, RRID:AB_2118062
- Product name
- HDAC1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HDAC1 antibody (Cat. #10197-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references LncRNA ZNFTR functions as an inhibitor in pancreatic cancer by modulating ATF3/ZNF24/VEGFA pathway.
Epigenetic derepression converts PPARγ into a druggable target in triple-negative and endocrine-resistant breast cancers.
MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail.
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
GCH1 induces immunosuppression through metabolic reprogramming and IDO1 upregulation in triple-negative breast cancer.
ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.
PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.
Aberrant HDAC3 expression correlates with brain metastasis in breast cancer patients.
Crosstalk between cardiomyocytes and noncardiomyocytes is essential to prevent cardiomyocyte apoptosis induced by proteasome inhibition.
The RNA exosome complex degrades expanded hexanucleotide repeat RNA in C9orf72 FTLD/ALS.
HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo.
USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3.
Increased NRSF/REST in anterior cingulate cortex contributes to diabetes-related neuropathic pain.
Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming.
EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression.
Signatures of host-pathogen evolutionary conflict reveal MISTR-A conserved MItochondrial STress Response network.
Hypoxia-induced feedback of HIF-1α and lncRNA-CF129 contributes to pancreatic cancer progression through stabilization of p53 protein.
SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2.
Histone deacetylase-1 as a prognostic factor and mediator of gastric cancer progression by enhancing glycolysis.
Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1.
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
Reversal of increased mammary tumorigenesis by valproic acid and hydralazine in offspring of dams fed high fat diet during pregnancy.
Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells.
Impaired FGF10 Signaling and Epithelial Development in Experimental Lung Hypoplasia With Esophageal Atresia.
The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction.
Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice.
Differential HDAC1/2 network analysis reveals a role for prefoldin/CCT in HDAC1/2 complex assembly.
Reciprocal loop of hypoxia-inducible factor-1α (HIF-1α) and metastasis-associated protein 2 (MTA2) contributes to the progression of pancreatic carcinoma by suppressing E-cadherin transcription.
The roles of SMYD4 in epigenetic regulation of cardiac development in zebrafish.
ABIN1 inhibits HDAC1 ubiquitination and protects it from both proteasome- and lysozyme-dependent degradation.
Regulatory Roles of Histone Deacetylases 1 and 2 in Pb-induced Neurotoxicity.
HDAC2 was involved in placental P-glycoprotein regulation both in vitro and vivo.
Effect of Histone Deacetylase Inhibition on the Expression of Multidrug Resistance-associated Protein 2 in a Human Placental Trophoblast Cell Line.
The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines.
Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition.
miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells.
The long non-coding RNA TUG1 indicates a poor prognosis for colorectal cancer and promotes metastasis by affecting epithelial-mesenchymal transition.
Identification of NOD2 as a novel target of RNA-binding protein HuR: evidence from NADPH oxidase-mediated HuR signaling in diabetic nephropathy.
Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis.
Specific immunotherapy in combination with Clostridium butyricum inhibits allergic inflammation in the mouse intestine.
Connexin32 regulates hepatoma cell metastasis and proliferation via the p53 and Akt pathways.
Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi‑1 leukemia cells.
Histone cross-talk connects protein phosphatase 1α (PP1α) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression.
PROX1 promotes hepatocellular carcinoma metastasis by way of up-regulating hypoxia-inducible factor 1α expression and protein stability.
FLASH knockdown sensitizes cells to Fas-mediated apoptosis via down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip short.
Modulation of Tcf3 repressor complex composition regulates cdx4 expression in zebrafish.
Li W, Han S, Hu P, Chen D, Zeng Z, Hu Y, Xu F, Tang J, Wang F, Zhao Y, Huang M, Zhao G
Cell death & disease 2021 Sep 3;12(9):830
Cell death & disease 2021 Sep 3;12(9):830
Epigenetic derepression converts PPARγ into a druggable target in triple-negative and endocrine-resistant breast cancers.
Loo SY, Syn NL, Koh AP, Teng JC, Deivasigamani A, Tan TZ, Thike AA, Vali S, Kapoor S, Wang X, Wang JW, Tan PH, Yip GW, Sethi G, Huang RY, Hui KM, Wang L, Goh BC, Kumar AP
Cell death discovery 2021 Sep 27;7(1):265
Cell death discovery 2021 Sep 27;7(1):265
MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail.
Huang W, Chen J, Liu X, Liu X, Duan S, Chen L, Liu X, Lan J, Zou Y, Guo D, Zhou J
Experimental cell research 2021 Sep 1;406(1):112722
Experimental cell research 2021 Sep 1;406(1):112722
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Chen M, Sun X, Wei W, Cucarella C, Martín-Sanz P, Casado M, Pi L, Ren B, Cao Q
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
GCH1 induces immunosuppression through metabolic reprogramming and IDO1 upregulation in triple-negative breast cancer.
Wei JL, Wu SY, Yang YS, Xiao Y, Jin X, Xu XE, Hu X, Li DQ, Jiang YZ, Shao ZM
Journal for immunotherapy of cancer 2021 Jul;9(7)
Journal for immunotherapy of cancer 2021 Jul;9(7)
ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.
Ma L, Yu L, Jiang BC, Wang J, Guo X, Huang Y, Ren J, Sun N, Gao DS, Ding H, Lu J, Zhou H, Zou L, Gao Y, Wang L, Sun K, Ming Y, Meng Z, Tao YX, Yan M
The Journal of experimental medicine 2021 Dec 6;218(12)
The Journal of experimental medicine 2021 Dec 6;218(12)
PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.
Yan L, Jin W, Zhao Q, Cui X, Shi T, Xu Y, Li F, Jin W, Zhang Z, Zhang Z, Tang QQ, Pan D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Aug;8(16):e2102060
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Aug;8(16):e2102060
Aberrant HDAC3 expression correlates with brain metastasis in breast cancer patients.
Ma L, Qi L, Li S, Yin Q, Liu J, Wang J, She C, Li P, Liu Q, Wang X, Li W
Thoracic cancer 2020 Sep;11(9):2493-2505
Thoracic cancer 2020 Sep;11(9):2493-2505
Crosstalk between cardiomyocytes and noncardiomyocytes is essential to prevent cardiomyocyte apoptosis induced by proteasome inhibition.
Guo F, Zhang CC, Yin XH, Li T, Fang CH, He XB
Cell death & disease 2020 Sep 19;11(9):783
Cell death & disease 2020 Sep 19;11(9):783
The RNA exosome complex degrades expanded hexanucleotide repeat RNA in C9orf72 FTLD/ALS.
Kawabe Y, Mori K, Yamashita T, Gotoh S, Ikeda M
The EMBO journal 2020 Oct 1;39(19):e102700
The EMBO journal 2020 Oct 1;39(19):e102700
HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo.
Sanna S, Esposito S, Masala A, Sini P, Nieddu G, Galioto M, Fais M, Iaccarino C, Cestra G, Crosio C
Cell death & disease 2020 May 14;11(5):369
Cell death & disease 2020 May 14;11(5):369
USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3.
Zhan W, Liao X, Liu J, Tian T, Yu L, Li R
Oncogenesis 2020 May 13;9(5):48
Oncogenesis 2020 May 13;9(5):48
Increased NRSF/REST in anterior cingulate cortex contributes to diabetes-related neuropathic pain.
Xiao-Die X, Xiao-Hong W, Cheng-Feng H, Zhong-Yu Y, Jian-Tao W, Hou-Guang Z, Jing-Chun G
Biochemical and biophysical research communications 2020 Jun 30;527(3):785-790
Biochemical and biophysical research communications 2020 Jun 30;527(3):785-790
Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming.
Feng S, Zhang L, Liu X, Li G, Zhang B, Wang Z, Zhang H, Ma H
Journal of cellular and molecular medicine 2020 Jul;24(14):7789-7801
Journal of cellular and molecular medicine 2020 Jul;24(14):7789-7801
EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression.
Zhao H, Wang Y, Yang C, Zhou J, Wang L, Yi K, Li Y, Wang Q, Shi J, Kang C, Zeng L
Clinical and translational medicine 2020 Jan 28;9(1):10
Clinical and translational medicine 2020 Jan 28;9(1):10
Signatures of host-pathogen evolutionary conflict reveal MISTR-A conserved MItochondrial STress Response network.
Sorouri M, Chang T, Jesudhasan P, Pinkham C, Elde NC, Hancks DC
PLoS biology 2020 Dec;18(12):e3001045
PLoS biology 2020 Dec;18(12):e3001045
Hypoxia-induced feedback of HIF-1α and lncRNA-CF129 contributes to pancreatic cancer progression through stabilization of p53 protein.
Liu M, Zhong J, Zeng Z, Huang K, Ye Z, Deng S, Chen H, Xu F, Li Q, Zhao G
Theranostics 2019;9(16):4795-4810
Theranostics 2019;9(16):4795-4810
SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2.
Zhang N, Zhang H, Liu Y, Su P, Zhang J, Wang X, Sun M, Chen B, Zhao W, Wang L, Wang H, Moran MS, Haffty BG, Yang Q
Cell death and differentiation 2019 May;26(5):843-859
Cell death and differentiation 2019 May;26(5):843-859
Histone deacetylase-1 as a prognostic factor and mediator of gastric cancer progression by enhancing glycolysis.
Jiang Z, Yang H, Zhang X, Wang Z, Rong R, Wang X
Human pathology 2019 Mar;85:194-201
Human pathology 2019 Mar;85:194-201
Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1.
Feng K, Deng F, Hu Z, Wang H, Ning YJ
The Journal of biological chemistry 2019 Jun 14;294(24):9503-9517
The Journal of biological chemistry 2019 Jun 14;294(24):9503-9517
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
Zhong S, Li L, Zhang YL, Zhang L, Lu J, Guo S, Liang N, Ge J, Zhu M, Tao Y, Wu YC, Yin H
The Journal of clinical investigation 2019 Jan 2;129(1):252-267
The Journal of clinical investigation 2019 Jan 2;129(1):252-267
Reversal of increased mammary tumorigenesis by valproic acid and hydralazine in offspring of dams fed high fat diet during pregnancy.
Andrade FO, Nguyen NM, Warri A, Hilakivi-Clarke L
Scientific reports 2019 Dec 30;9(1):20271
Scientific reports 2019 Dec 30;9(1):20271
Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells.
Bando H, Sakaguchi N, Lee Y, Pradipta A, Ma JS, Tanaka S, Lai DH, Liu J, Lun ZR, Nishikawa Y, Sasai M, Yamamoto M
Frontiers in immunology 2018;9:2073
Frontiers in immunology 2018;9:2073
Impaired FGF10 Signaling and Epithelial Development in Experimental Lung Hypoplasia With Esophageal Atresia.
Wang J, Liu H, Gao L, Liu X
Frontiers in pediatrics 2018;6:109
Frontiers in pediatrics 2018;6:109
The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction.
He B, Dai L, Zhang X, Chen D, Wu J, Feng X, Zhang Y, Xie H, Zhou L, Wu J, Zheng S
International journal of biological sciences 2018;14(13):1845-1858
International journal of biological sciences 2018;14(13):1845-1858
Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice.
Duan HY, Zhou KY, Wang T, Zhang Y, Li YF, Hua YM, Wang C
Chinese medical journal 2018 Sep 5;131(17):2080-2088
Chinese medical journal 2018 Sep 5;131(17):2080-2088
Differential HDAC1/2 network analysis reveals a role for prefoldin/CCT in HDAC1/2 complex assembly.
Banks CAS, Miah S, Adams MK, Eubanks CG, Thornton JL, Florens L, Washburn MP
Scientific reports 2018 Sep 12;8(1):13712
Scientific reports 2018 Sep 12;8(1):13712
Reciprocal loop of hypoxia-inducible factor-1α (HIF-1α) and metastasis-associated protein 2 (MTA2) contributes to the progression of pancreatic carcinoma by suppressing E-cadherin transcription.
Zhu S, Deng S, He C, Liu M, Chen H, Zeng Z, Zhong J, Ye Z, Deng S, Wu H, Wang C, Zhao G
The Journal of pathology 2018 Jul;245(3):349-360
The Journal of pathology 2018 Jul;245(3):349-360
The roles of SMYD4 in epigenetic regulation of cardiac development in zebrafish.
Xiao D, Wang H, Hao L, Guo X, Ma X, Qian Y, Chen H, Ma J, Zhang J, Sheng W, Shou W, Huang G, Ma D
PLoS genetics 2018 Aug;14(8):e1007578
PLoS genetics 2018 Aug;14(8):e1007578
ABIN1 inhibits HDAC1 ubiquitination and protects it from both proteasome- and lysozyme-dependent degradation.
Ma Y, Yuan S, Tian X, Lin S, Wei S, Hu T, Chen S, Li X, Chen S, Wu D, Wang M, Guo D
Journal of cellular biochemistry 2018 Apr;119(4):3030-3043
Journal of cellular biochemistry 2018 Apr;119(4):3030-3043
Regulatory Roles of Histone Deacetylases 1 and 2 in Pb-induced Neurotoxicity.
Wu Y, Xu Y, Huang X, Ye D, Han M, Wang HL
Toxicological sciences : an official journal of the Society of Toxicology 2018 Apr 1;162(2):688-701
Toxicological sciences : an official journal of the Society of Toxicology 2018 Apr 1;162(2):688-701
HDAC2 was involved in placental P-glycoprotein regulation both in vitro and vivo.
Duan H, Zhou K, Zhang Y, Yue P, Wang T, Li Y, Qiu D, Wu J, Hua Y, Wang C
Placenta 2017 Oct;58:105-114
Placenta 2017 Oct;58:105-114
Effect of Histone Deacetylase Inhibition on the Expression of Multidrug Resistance-associated Protein 2 in a Human Placental Trophoblast Cell Line.
Duan HY, Ma D, Zhou KY, Wang T, Zhang Y, Li YF, Wu JL, Hua YM, Wang C
Chinese medical journal 2017 Jun 5;130(11):1352-1360
Chinese medical journal 2017 Jun 5;130(11):1352-1360
The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines.
Duan H, Wang C, Zhou K, Wang T, Li Y, Qiu D, Li Q, Zhang Y, Hua Y
Placenta 2017 Jan;49:37-47
Placenta 2017 Jan;49:37-47
Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition.
Wang F, Zhao J, Liu D, Zhao T, Lu Z, Zhu L, Cao L, Yang J, Jin J, Cai Y
Cancer biology & therapy 2016 Nov;17(11):1117-1125
Cancer biology & therapy 2016 Nov;17(11):1117-1125
miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells.
He XH, Zhu W, Yuan P, Jiang S, Li D, Zhang HW, Liu MF
Oncogene 2016 Nov 17;35(46):6015-6025
Oncogene 2016 Nov 17;35(46):6015-6025
The long non-coding RNA TUG1 indicates a poor prognosis for colorectal cancer and promotes metastasis by affecting epithelial-mesenchymal transition.
Sun J, Ding C, Yang Z, Liu T, Zhang X, Zhao C, Wang J
Journal of translational medicine 2016 Feb 8;14:42
Journal of translational medicine 2016 Feb 8;14:42
Identification of NOD2 as a novel target of RNA-binding protein HuR: evidence from NADPH oxidase-mediated HuR signaling in diabetic nephropathy.
Shang J, Wan Q, Wang X, Duan Y, Wang Z, Wei X, Zhang Y, Wang H, Wang R, Yi F
Free radical biology & medicine 2015 Feb;79:217-27
Free radical biology & medicine 2015 Feb;79:217-27
Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis.
Cai M, Hu Z, Liu J, Gao J, Tan M, Zhang D, Zhu L, Liu S, Hou R, Lin B
Oncology reports 2015 Feb;33(2):685-92
Oncology reports 2015 Feb;33(2):685-92
Specific immunotherapy in combination with Clostridium butyricum inhibits allergic inflammation in the mouse intestine.
Shi Y, Xu LZ, Peng K, Wu W, Wu R, Liu ZQ, Yang G, Geng XR, Liu J, Liu ZG, Liu Z, Yang PC
Scientific reports 2015 Dec 2;5:17651
Scientific reports 2015 Dec 2;5:17651
Connexin32 regulates hepatoma cell metastasis and proliferation via the p53 and Akt pathways.
Zhao B, Zhao W, Wang Y, Xu Y, Xu J, Tang K, Zhang S, Yin Z, Wu Q, Wang X
Oncotarget 2015 Apr 30;6(12):10116-33
Oncotarget 2015 Apr 30;6(12):10116-33
Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi‑1 leukemia cells.
Zhang ZH, Hao CL, Liu P, Tian X, Wang LH, Zhao L, Zhu CM
Molecular medicine reports 2014 Feb;9(2):443-9
Molecular medicine reports 2014 Feb;9(2):443-9
Histone cross-talk connects protein phosphatase 1α (PP1α) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression.
Hu X, Lu X, Liu R, Ai N, Cao Z, Li Y, Liu J, Yu B, Liu K, Wang H, Zhou C, Wang Y, Han A, Ding F, Chen R
The Journal of biological chemistry 2014 Aug 15;289(33):23154-23167
The Journal of biological chemistry 2014 Aug 15;289(33):23154-23167
PROX1 promotes hepatocellular carcinoma metastasis by way of up-regulating hypoxia-inducible factor 1α expression and protein stability.
Liu Y, Zhang JB, Qin Y, Wang W, Wei L, Teng Y, Guo L, Zhang B, Lin Z, Liu J, Ren ZG, Ye QH, Xie Y
Hepatology (Baltimore, Md.) 2013 Aug;58(2):692-705
Hepatology (Baltimore, Md.) 2013 Aug;58(2):692-705
FLASH knockdown sensitizes cells to Fas-mediated apoptosis via down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip short.
Chen S, Evans HG, Evans DR
PloS one 2012;7(3):e32971
PloS one 2012;7(3):e32971
Modulation of Tcf3 repressor complex composition regulates cdx4 expression in zebrafish.
Ro H, Dawid IB
The EMBO journal 2011 Jun 10;30(14):2894-907
The EMBO journal 2011 Jun 10;30(14):2894-907
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 10197-1-AP(HDAC1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of SH-SY5Y cells, using HDAC1 antibody 10197-1-AP at 1:50 dilution and FITC-labeled donkey anti-rabbit IgG(green).
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-HDAC1 (IP:10197-1-AP, 3ug; Detection:10197-1-AP 1:500) with mouse testis tissue lysate 10000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 10197-1-AP(HDAC1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue