BS8258

antibody from Bioworld Technology, Inc
Targeting: RFFL CARP-2, CARP2, fring, rififylin, RNF189, RNF34L
Provider product page for BS8258
Western blot
Immunohistochemistry

Antibody data

Product number
BS8258 - Provider product page
Provider
Bioworld Technology, Inc
Product name
RFFL polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human RFFL.
Description
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). RFFL, also known as RNF189, RNF34L or Rififylin, is a 363 amino acid protein that localizes to both the cytoplasm and to the membrane and contains one FYVE-type zinc finger, one RING-type zinc finger and two SAP domains. Expressed ubiquitously with increased expression in testis, spleen, ovary and prostate, RFFL functions as an E3 ubiquitin-protein ligase that interacts with caspase-8 and caspase-10 and targets them for proteasomal degradation. Multiple isoforms of RFFL exist due to alternative splicing events.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
RFFL protein structure - BS8258 shown in red.