Ab103920

antibody from Aladdin Scientific Corporation

Targeting: FOXA2 HNF3B

Western blot (Data presented on provider website)

Antibody Data

Product number

Ab103920

Provider

Aladdin Scientific Corporation

Product name

Recombinant FOXA2 Antibody

Antibody type

Recombinant

Description

Rabbit anti Human FOXA2 Antibody, Recombinant (R07-3H4), could be used for WB and so on.ApplicationWB: 1/500 – 1/2000Protein FunctionTranscription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

AA 1-53


Antibody clone number

R07-3H4

Vial size

100μl,10μl,1ml,50μl

Concentration

1,5 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.