Antibody data

Product number
10-8013 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-SOX10 Antibody
Antibody type
Monoclonal
Description
SOX10 is a transcription factor that belongs to the high mobility group (HMG) box super family of DNA-binding proteins. It is located at 22q13.1 and is highly conserved in vertebrates. SOX10 is expressed in many different cell types and tissues and implicated in neural crest development, nervous system neurogenesis, as well as differentiation of oligodendrocyte, glia and melanocytes. It modulates other transcription factors including PAX3 forming a complex and acts as a nucleocytoplasmic shuttle protein in neural crest and oligodendrocyte development. The level of expression of SOX10 plays pivotal regulatory role both in tumor progression and suppression. Its elevated expression, possess tumor-promoting activities in several malignancies including melanoma and gliomas. Decreased expression of SOX10 promotes tumor cell growth and focal adhesions of Merlin-null schwannoma cells. SOX10 may also function as a tumor suppressor by inducing tumor cell apoptosis, inhibiting invasion, regulating cell EMT and stemness through suppressing Wnt/Beta-catenin signaling. Mutations of the Sox10 gene are known to cause various combinations of hearing loss and pigmentation defects in humans such as Waardenburg syndrome, a rare auditory-pigmentary disorder that generates varying combinations of hearing loss and pigmentation defects.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant SOX-10
protein (amino acids 115-269) was
used as the immunogen for this anti
body.
Isotype
IgG
Antibody clone number
ABM42D7
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
SOX10 protein structure - 10-8013 shown in red.