Antibody data
- Antibody Data
- Antigen structure
- References [20]
- Comments [0]
- Validations
- Immunocytochemistry [1]
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- Product number
- AF2864 - Provider product page
- Provider
- R&D Systems
- Product name
- Human SOX10 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human SOX10 in direct ELISAs and Western blots.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
P56693
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Dynamics of oligodendrocyte generation in multiple sclerosis.
Notch signalling defines dorsal root ganglia neuroglial fate choice during early neural crest cell migration.
Central and Peripheral Nervous System Progenitors Derived from Human Pluripotent Stem Cells Reveal a Unique Temporal and Cell-Type Specific Expression of PMCAs.
A unique role for DNA (hydroxy)methylation in epigenetic regulation of human inhibitory neurons.
Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells.
Intracellular attenuation of BMP signaling via CKIP-1/Smurf1 is essential during neural crest induction.
The Dorsal Wave of Neocortical Oligodendrogenesis Begins Embryonically and Requires Multiple Sources of Sonic Hedgehog.
Generation of Adrenal Chromaffin-like Cells from Human Pluripotent Stem Cells.
Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system.
SOX10 Expression as Well as BRAF and GNAQ/11 Mutations Distinguish Pigmented Ciliary Epithelium Neoplasms From Uveal Melanomas.
Graded Elevation of c-Jun in Schwann Cells In Vivo: Gene Dosage Determines Effects on Development, Remyelination, Tumorigenesis, and Hypomyelination.
Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes.
Elevated Levels of SOX10 in Serum from Vitiligo and Melanoma Patients, Analyzed by Proximity Ligation Assay.
YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells.
Dynamic regulation of Schwann cell enhancers after peripheral nerve injury.
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.
Double minute amplification of mutant PDGF receptor α in a mouse glioma model.
Migrating cells mediate long-range WNT signaling.
Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells.
Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad.
Yeung MSY, Djelloul M, Steiner E, Bernard S, Salehpour M, Possnert G, Brundin L, Frisén J
Nature 2019 Feb;566(7745):538-542
Nature 2019 Feb;566(7745):538-542
Notch signalling defines dorsal root ganglia neuroglial fate choice during early neural crest cell migration.
Wiszniak S, Schwarz Q
BMC neuroscience 2019 Apr 29;20(1):21
BMC neuroscience 2019 Apr 29;20(1):21
Central and Peripheral Nervous System Progenitors Derived from Human Pluripotent Stem Cells Reveal a Unique Temporal and Cell-Type Specific Expression of PMCAs.
Chen M, Laursen SH, Habekost M, Knudsen CH, Buchholdt SH, Huang J, Xu F, Liu X, Bolund L, Luo Y, Nissen P, Febbraro F, Denham M
Frontiers in cell and developmental biology 2018;6:5
Frontiers in cell and developmental biology 2018;6:5
A unique role for DNA (hydroxy)methylation in epigenetic regulation of human inhibitory neurons.
Kozlenkov A, Li J, Apontes P, Hurd YL, Byne WM, Koonin EV, Wegner M, Mukamel EA, Dracheva S
Science advances 2018 Sep;4(9):eaau6190
Science advances 2018 Sep;4(9):eaau6190
Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells.
Lager AM, Corradin OG, Cregg JM, Elitt MS, Shick HE, Clayton BLL, Allan KC, Olsen HE, Madhavan M, Tesar PJ
Nature communications 2018 Sep 13;9(1):3708
Nature communications 2018 Sep 13;9(1):3708
Intracellular attenuation of BMP signaling via CKIP-1/Smurf1 is essential during neural crest induction.
Piacentino ML, Bronner ME
PLoS biology 2018 Jun;16(6):e2004425
PLoS biology 2018 Jun;16(6):e2004425
The Dorsal Wave of Neocortical Oligodendrogenesis Begins Embryonically and Requires Multiple Sources of Sonic Hedgehog.
Winkler CC, Yabut OR, Fregoso SP, Gomez HG, Dwyer BE, Pleasure SJ, Franco SJ
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Jun 6;38(23):5237-5250
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Jun 6;38(23):5237-5250
Generation of Adrenal Chromaffin-like Cells from Human Pluripotent Stem Cells.
Abu-Bonsrah KD, Zhang D, Bjorksten AR, Dottori M, Newgreen DF
Stem cell reports 2018 Jan 9;10(1):134-150
Stem cell reports 2018 Jan 9;10(1):134-150
Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system.
Figlia G, Norrmén C, Pereira JA, Gerber D, Suter U
eLife 2017 Sep 7;6
eLife 2017 Sep 7;6
SOX10 Expression as Well as BRAF and GNAQ/11 Mutations Distinguish Pigmented Ciliary Epithelium Neoplasms From Uveal Melanomas.
Mori T, Sukeda A, Sekine S, Shibata S, Ryo E, Okano H, Suzuki S, Hiraoka N
Investigative ophthalmology & visual science 2017 Oct 1;58(12):5445-5451
Investigative ophthalmology & visual science 2017 Oct 1;58(12):5445-5451
Graded Elevation of c-Jun in Schwann Cells In Vivo: Gene Dosage Determines Effects on Development, Remyelination, Tumorigenesis, and Hypomyelination.
Fazal SV, Gomez-Sanchez JA, Wagstaff LJ, Musner N, Otto G, Janz M, Mirsky R, Jessen KR
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Dec 13;37(50):12297-12313
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Dec 13;37(50):12297-12313
Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes.
Nevin ZS, Factor DC, Karl RT, Douvaras P, Laukka J, Windrem MS, Goldman SA, Fossati V, Hobson GM, Tesar PJ
American journal of human genetics 2017 Apr 6;100(4):617-634
American journal of human genetics 2017 Apr 6;100(4):617-634
Elevated Levels of SOX10 in Serum from Vitiligo and Melanoma Patients, Analyzed by Proximity Ligation Assay.
Blokzijl A, Chen LE, Gustafsdottir SM, Vuu J, Ullenhag G, Kämpe O, Landegren U, Kamali-Moghaddam M, Hedstrand H
PloS one 2016;11(4):e0154214
PloS one 2016;11(4):e0154214
YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells.
Poitelon Y, Lopez-Anido C, Catignas K, Berti C, Palmisano M, Williamson C, Ameroso D, Abiko K, Hwang Y, Gregorieff A, Wrana JL, Asmani M, Zhao R, Sim FJ, Wrabetz L, Svaren J, Feltri ML
Nature neuroscience 2016 Jul;19(7):879-87
Nature neuroscience 2016 Jul;19(7):879-87
Dynamic regulation of Schwann cell enhancers after peripheral nerve injury.
Hung HA, Sun G, Keles S, Svaren J
The Journal of biological chemistry 2015 Mar 13;290(11):6937-50
The Journal of biological chemistry 2015 Mar 13;290(11):6937-50
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.
Najm FJ, Madhavan M, Zaremba A, Shick E, Karl RT, Factor DC, Miller TE, Nevin ZS, Kantor C, Sargent A, Quick KL, Schlatzer DM, Tang H, Papoian R, Brimacombe KR, Shen M, Boxer MB, Jadhav A, Robinson AP, Podojil JR, Miller SD, Miller RH, Tesar PJ
Nature 2015 Jun 11;522(7555):216-20
Nature 2015 Jun 11;522(7555):216-20
Double minute amplification of mutant PDGF receptor α in a mouse glioma model.
Zou H, Feng R, Huang Y, Tripodi J, Najfeld V, Tsankova NM, Jahanshahi M, Olson LE, Soriano P, Friedel RH
Scientific reports 2015 Feb 16;5:8468
Scientific reports 2015 Feb 16;5:8468
Migrating cells mediate long-range WNT signaling.
Serralbo O, Marcelle C
Development (Cambridge, England) 2014 May;141(10):2057-63
Development (Cambridge, England) 2014 May;141(10):2057-63
Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells.
Najm FJ, Lager AM, Zaremba A, Wyatt K, Caprariello AV, Factor DC, Karl RT, Maeda T, Miller RH, Tesar PJ
Nature biotechnology 2013 May;31(5):426-33
Nature biotechnology 2013 May;31(5):426-33
Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad.
Nagoshi N, Shibata S, Kubota Y, Nakamura M, Nagai Y, Satoh E, Morikawa S, Okada Y, Mabuchi Y, Katoh H, Okada S, Fukuda K, Suda T, Matsuzaki Y, Toyama Y, Okano H
Cell stem cell 2008 Apr 10;2(4):392-403
Cell stem cell 2008 Apr 10;2(4):392-403
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- SOX10 in BG01V Human Embryonic Stem Cells. SOX10 was detected in immersion fixed BG01V human embryonic stem cells differentiated to neural crest stem cells using Goat Anti-Human SOX10 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2864) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.