BS3650

DOK1 antibody from Bioworld Technology, Inc
p62dok
Western blot
Supportive data in Antibodypedia
Immunohistochemistry
Data presented on provider website

Antibody data

Product number
BS3650
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS3650, RRID:AB_1663140
Product name
Dok 1 (R392) polyclonal antibody
Provider product page
Bioworld Technology, Inc - BS3650
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 360-408 of Human Dok-1.
Description
Dok-1 associates with the Ras GTPase-activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that Dok-1 (also designated p62dok) is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, are members of a class of ¡ùdocking¡ì proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.