CABT-B9287

antibody from Creative Diagnostics

Targeting: PLCG1 NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B9287

Provider

Creative Diagnostics

Product name

Mouse anti-Cow Phospholipase CÎÛ1 monoclonal antibody, clone 20

Antibody type

Monoclonal

Description

The Phospholipase C (PLC) isozymes hydrolyze phosphatidyl inositol biphosphate to inositol triphosphate and diacylglycerol. The former causes release of calcium from the endoplasmic reticulum, while the latter is an activator of Protein Kinase C. Within the PLC family, PLCÎÛ is the only member that contains SH2 and SH3 domains. These domains enable it to interact with receptor tyrosine kinases and become enzymatically activated via phosphorylation. It exists as two isoforms: 1) PLCÎÛ1, which is ubiquitously expressed, and 2) PLCÎÛ2, found primarily in the lymphoid system. PLCÎÛ is essential for growth factor-induced cell motility and mitogenesis. PLCÎÛ1 null mice exhibit retarded embryonic growth and lethality in midgestation. Overexpression of PLCÎÛ is evident in several forms of cancer, and it has been identified as a key mediator of PDGF-dependent cellular transformation. Thus regulation of PLCÎÛ activity by growth factors is involved in cell growth and transformation.

Reactivity

Human, Mouse, Rat, Canine, Chicken/Avian

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

20

Vial size

50ug, 150ug

Concentration

250 Ã×g/ml

Storage

Store undiluted at -20°C.