BS6693

antibody from Bioworld Technology, Inc
Targeting: PLCG2
Provider product page for BS6693
Western blot
Immunocytochemistry
Immunoprecipitation
Immunohistochemistry

Antibody data

Product number
BS6693 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PLC ÎÛ2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human PLC ÎÛ2.
Description
Phosphoinositide-specific phospholipase C (PLC) plays a critical role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate.There are many mammalian PLC isozymes, including PLC ÉÇ1, PLC ÉÇ2, PLC ÉÇ3, PLC ÉÇ4, PLC ÎÛ1, PLC ÎÛ2, PLC ?1, PLC ?2 and PLC e. After stimulation of the collagen receptor glycoprotein VI in human platelets, PLC ÎÛ2 associates with several tyrosine-phosphorylated proteins (Syk, SLP-76, Lyn, linker for activation of T cells (LAT) and the FcR ÎÛ chain), which bind to its C-terminal SH2 domain. PLC ÎÛ1 associates with Syk in B cells, but PLC ÎÛ2 does not associate with Syk in platelets. The C-terminal SH2 domain is involved in the regulation of PLC ÎÛ2. In addition, Btk can induce PLC ÎÛ2 tyrosine phosphorylation and initiate calcium moblization in CD72-stimulated B lymphocytes.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PLCG2 protein structure - BS6693 shown in red.