AMM01493G

antibody from Leading Biology

Targeting: CD8B CD8B1

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

AMM01493G

Provider

Leading Biology

Product name

CD8B (Cytotoxic / Suppressor T-Cell Marker) Antibody - With BSA and Azide

Antibody type

Monoclonal

Description

The T cell receptor (TCR) is a heterodimer composed of either Ī � and Ī � or Ī � and Ī � chains. CD3 chains and the CD4 or CD8 co-receptors are also required for efficient signal transduction through the TCR. The TCR is expressed on T helper and T cytotoxic cells that can be distinguished by their expression of CD4 and CD8. T helper cells express CD4 proteins and T cytotoxic cells display CD8. CD8 (also designated Leu 2 or T8), a cell surface glycoprotein, is a two chain complex (Ī �-Ī � or Ī �-Ī �) receptor that binds class I MHC molecules presented by the antigen-presenting cell (APC). A primary function of CD8 is to facilitate antigen recognition by the TCR and to strengthen the avidity of the TCR-antigen interactions. An additional role for CD8-expressing T cells may be to maintain low levels of HIV expression.

Reactivity

Human

Host

Mouse

Antibody clone number

BU88

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.