Antibody data
- Antibody Data
- Antigen structure
- References [58]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 10155-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10155-1-AP, RRID:AB_2078096
- Product name
- CDC42 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CDC42 antibody (Cat. #10155-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Plexin D1 negatively regulates macrophage-derived foam cell migration via the focal adhesion kinase/Paxillin pathway.
Proangiogenic effect and underlying mechanism of holmium oxide nanoparticles: a new biomaterial for tissue engineering.
Estrogen inhibits TGF‑β1‑stimulated cardiac fibroblast differentiation and collagen synthesis by promoting Cdc42.
Dahuang-Taoren, a botanical drug combination, ameliorates adenomyosis via inhibiting Rho GTPases.
Epithelial-specific deletion of FAM20A leads to short root defects.
Neuropilin 1 is an entry receptor for KSHV infection of mesenchymal stem cell through TGFBR1/2-mediated macropinocytosis.
Guanine nucleotide exchange factor T exerts the cancer-promoting function in cholangiocarcinoma by enhancing the Wnt-GSK-3β-β-catenin cascade via regulation of Rac1/Cdc42.
Superhydrophilic and topography-regulatable surface grafting on PEEK to improve cellular affinity.
Fam20c regulates the calpain proteolysis system through phosphorylating Calpasatatin to maintain cell homeostasis.
ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells.
Biallelic variants in IQCN cause sperm flagellar assembly defects and male infertility.
Oral exposure to polystyrene nanoplastics reduced male fertility and even caused male infertility by inducing testicular and sperm toxicities in mice.
Human Umbilical Cord Mesenchymal Stem Cells Improve the Status of Hypoxic/Ischemic Cerebral Palsy Rats by Downregulating NogoA/NgR/Rho Pathway.
Macrophages modulate stiffness-related foreign body responses through plasma membrane deformation.
Bacterial infection promotes tumorigenesis of colorectal cancer via regulating CDC42 acetylation.
RhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling.
Cell-in-Cell-Mediated Entosis Reveals a Progressive Mechanism in Pancreatic Cancer.
TRIM67 Implicates in Regulating the Homeostasis and Synaptic Development of Mitral Cells in the Olfactory Bulb.
Inhibition of Cxcr4 Disrupts Mouse Embryonic Palatal Mesenchymal Cell Migration and Induces Cleft Palate Occurrence.
FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC contractility, and blood pressure by multiple mechanisms.
Overexpression of PTPRZ1 Regulates p120/β-Catenin Phosphorylation to Promote Carcinogenesis of Oral Submucous Fibrosis.
Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion.
eIF3a Regulates Colorectal Cancer Metastasis via Translational Activation of RhoA and Cdc42.
PFN1 Inhibits Myogenesis of Bovine Myoblast Cells via Cdc42-PAK/JNK.
SARS-CoV-2 hijacks macropinocytosis to facilitate its entry and promote viral spike-mediated cell-to-cell fusion.
CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
Non-canonical Wnt/calcium signaling is protective against podocyte injury and glomerulosclerosis.
C9orf72 knockdown alleviates hepatic insulin resistance by promoting lipophagy.
Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.
Hypermethylation of PRKCZ Regulated by E6 Inhibits Invasion and EMT via Cdc42 in HPV-Related Head and Neck Squamous Cell Carcinoma.
Effects of hydrogen peroxide on endothelial function in three-dimensional hydrogel vascular model and regulation mechanism of polar protein Par3.
MicroRNA-124-3p Plays a Crucial Role in Cleft Palate Induced by Retinoic Acid.
Intestinal Metabolites Influence Macrophage Phagocytosis and Clearance of Bacterial Infection.
miR-497 defect contributes to gastric cancer tumorigenesis and progression via regulating CDC42/ITGB1/FAK/PXN/AKT signaling.
Overexpression of DTL enhances cell motility and promotes tumor metastasis in cervical adenocarcinoma by inducing RAC1-JNK-FOXO1 axis.
Spatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the THP-1 human leukaemia cell line.
EGFR and ERK activation resists flavonoid quercetin-induced anticancer activities in human cervical cancer cells in vitro.
PCGF3 promotes the proliferation and migration of non-small cell lung cancer cells via the PI3K/AKT signaling pathway.
Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration.
DOCK7 protects against replication stress by promoting RPA stability on chromatin.
2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol (SQ) inhibits cancer cell metastasis behavior of TNBC via suppressing EMT and VEGF.
FGD1 exhibits oncogenic properties in hepatocellular carcinoma through regulating cell morphology, autophagy and mitochondrial function.
Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate.
Transcriptional Downregulation of miR-4306 serves as a New Therapeutic Target for Triple Negative Breast Cancer.
miR-29a inhibits adhesion, migration, and invasion of osteosarcoma cells by suppressing CDC42.
Influence of Wilms' tumor suppressor gene WT1 on bovine Sertoli cells polarity and tight junctions via non-canonical WNT signaling pathway.
Proteomics Analysis Identifies IRSp53 and Fascin as Critical for PRV Egress and Direct Cell-Cell Transmission.
Adenoviral vector-induced silencing of RGMa attenuates blood-brain barrier dysfunction in a rat model of MCAO/reperfusion.
miR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin gene.
GRHL2 suppresses tumor metastasis via regulation of transcriptional activity of RhoG in non-small cell lung cancer.
Inhibition of KLF5-Myo9b-RhoA Pathway-Mediated Podosome Formation in Macrophages Ameliorates Abdominal Aortic Aneurysm.
Graphene Oxide Induced Perturbation to Plasma Membrane and Cytoskeletal Meshwork Sensitize Cancer Cells to Chemotherapeutic Agents.
Nicotine facilitates VSMC dysfunction through a miR-200b/RhoGDIA/cytoskeleton module.
Dihydroartemisinin suppresses pancreatic cancer cells via a microRNA-mRNA regulatory network.
Baculovirus induces host cell aggregation via a Rho/Rok-dependent mechanism.
Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets.
α1β1 integrin/Rac1-dependent mesangial invasion of glomerular capillaries in Alport syndrome.
Toosendanin induces apoptosis through suppression of JNK signaling pathway in HL-60 cells.
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CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
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Biochemical and biophysical research communications 2022 Jan 15;588:15-22
Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.
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Hypermethylation of PRKCZ Regulated by E6 Inhibits Invasion and EMT via Cdc42 in HPV-Related Head and Neck Squamous Cell Carcinoma.
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Cancers 2022 Aug 27;14(17)
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Effects of hydrogen peroxide on endothelial function in three-dimensional hydrogel vascular model and regulation mechanism of polar protein Par3.
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Frontiers in cell and developmental biology 2021;9:621045
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Overexpression of DTL enhances cell motility and promotes tumor metastasis in cervical adenocarcinoma by inducing RAC1-JNK-FOXO1 axis.
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Oncology letters 2021 Nov;22(5):754
PCGF3 promotes the proliferation and migration of non-small cell lung cancer cells via the PI3K/AKT signaling pathway.
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Experimental cell research 2021 Mar 15;400(2):112496
Experimental cell research 2021 Mar 15;400(2):112496
Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration.
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Oncology letters 2021 Jan;21(1):59
Oncology letters 2021 Jan;21(1):59
DOCK7 protects against replication stress by promoting RPA stability on chromatin.
Gao M, Guo G, Huang J, Hou X, Ham H, Kim W, Zhao F, Tu X, Zhou Q, Zhang C, Zhu Q, Liu J, Yan Y, Xu Z, Yin P, Luo K, Weroha J, Deng M, Billadeau DD, Lou Z
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Nucleic acids research 2021 Apr 6;49(6):3322-3337
2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol (SQ) inhibits cancer cell metastasis behavior of TNBC via suppressing EMT and VEGF.
Zheng D, Wu Z, Han J, Guan Q, Li Z, Zuo D, Zhang W, Wu Y
Chemico-biological interactions 2020 Sep 25;329:109202
Chemico-biological interactions 2020 Sep 25;329:109202
FGD1 exhibits oncogenic properties in hepatocellular carcinoma through regulating cell morphology, autophagy and mitochondrial function.
Zeng Y, Guo Z, Hu Z, Liu M, Chen Y, Chen S, Peng B, Zhang P, Wu Z, Luo H, Zhong F, Jiang K, Lu Y, Yuan G, He S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:110029
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:110029
Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate.
Li M, Min W, Wang J, Wang L, Li Y, Zhou N, Yang Z, Qian Q
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Experimental and therapeutic medicine 2020 Apr;19(4):2861-2870
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Theranostics 2019;9(5):1401-1416
miR-29a inhibits adhesion, migration, and invasion of osteosarcoma cells by suppressing CDC42.
Liu ZJ, Chen SG, Yang YZ, Lu SJ, Zhao XM, Hu B, Zhang L
International journal of clinical and experimental pathology 2019;12(11):4171-4180
International journal of clinical and experimental pathology 2019;12(11):4171-4180
Influence of Wilms' tumor suppressor gene WT1 on bovine Sertoli cells polarity and tight junctions via non-canonical WNT signaling pathway.
Wang X, Adegoke EO, Ma M, Huang F, Zhang H, Adeniran SO, Zheng P, Zhang G
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Theriogenology 2019 Oct 15;138:84-93
Proteomics Analysis Identifies IRSp53 and Fascin as Critical for PRV Egress and Direct Cell-Cell Transmission.
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Proteomics 2019 Dec;19(23):e1900009
Adenoviral vector-induced silencing of RGMa attenuates blood-brain barrier dysfunction in a rat model of MCAO/reperfusion.
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Brain research bulletin 2018 Sep;142:54-62
miR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin gene.
Li Y, Zhang H, Gong H, Yuan Y, Li Y, Wang C, Li W, Zhang Z, Liu M, Liu H, Chen J
Journal of experimental & clinical cancer research : CR 2018 Jul 9;37(1):141
Journal of experimental & clinical cancer research : CR 2018 Jul 9;37(1):141
GRHL2 suppresses tumor metastasis via regulation of transcriptional activity of RhoG in non-small cell lung cancer.
Pan X, Zhang R, Xie C, Gan M, Yao S, Yao Y, Jin J, Han T, Huang Y, Gong Y, Wang J, Yu B
American journal of translational research 2017;9(9):4217-4226
American journal of translational research 2017;9(9):4217-4226
Inhibition of KLF5-Myo9b-RhoA Pathway-Mediated Podosome Formation in Macrophages Ameliorates Abdominal Aortic Aneurysm.
Ma D, Zheng B, Suzuki T, Zhang R, Jiang C, Bai D, Yin W, Yang Z, Zhang X, Hou L, Zhan H, Wen JK
Circulation research 2017 Mar 3;120(5):799-815
Circulation research 2017 Mar 3;120(5):799-815
Graphene Oxide Induced Perturbation to Plasma Membrane and Cytoskeletal Meshwork Sensitize Cancer Cells to Chemotherapeutic Agents.
Zhu J, Xu M, Gao M, Zhang Z, Xu Y, Xia T, Liu S
ACS nano 2017 Mar 28;11(3):2637-2651
ACS nano 2017 Mar 28;11(3):2637-2651
Nicotine facilitates VSMC dysfunction through a miR-200b/RhoGDIA/cytoskeleton module.
Liang D, Wang Z, Yan Z, Hou S, Xu W, Wang L, Shang M, Qiao Z
Scientific reports 2017 Mar 2;7:43798
Scientific reports 2017 Mar 2;7:43798
Dihydroartemisinin suppresses pancreatic cancer cells via a microRNA-mRNA regulatory network.
Li Y, Wang Y, Kong R, Xue D, Pan S, Chen H, Sun B
Oncotarget 2016 Sep 20;7(38):62460-62473
Oncotarget 2016 Sep 20;7(38):62460-62473
Baculovirus induces host cell aggregation via a Rho/Rok-dependent mechanism.
Deng Z, Huang Z, Yuan M, Yang K, Pang Y
The Journal of general virology 2014 Oct;95(Pt 10):2310-2320
The Journal of general virology 2014 Oct;95(Pt 10):2310-2320
Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets.
Zhou T, Zhang B, Wei P, Du Y, Zhou H, Yu M, Yan L, Zhang W, Nie G, Chen C, Tu Y, Wei T
Biomaterials 2014 Dec;35(37):9833-9843
Biomaterials 2014 Dec;35(37):9833-9843
α1β1 integrin/Rac1-dependent mesangial invasion of glomerular capillaries in Alport syndrome.
Zallocchi M, Johnson BM, Meehan DT, Delimont D, Cosgrove D
The American journal of pathology 2013 Oct;183(4):1269-1280
The American journal of pathology 2013 Oct;183(4):1269-1280
Toosendanin induces apoptosis through suppression of JNK signaling pathway in HL-60 cells.
Ju J, Qi Z, Cai X, Cao P, Liu N, Wang S, Chen Y
Toxicology in vitro : an international journal published in association with BIBRA 2013 Feb;27(1):232-8
Toxicology in vitro : an international journal published in association with BIBRA 2013 Feb;27(1):232-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 10155-1-AP(CDC42 antibody) at dilution of 1:0
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CDC42 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CDC42. This antibody recognizes human, mouse, rat antigen. The CDC42 antibody has been validated for the following applications: ELISA, WB, IHC analysis.