BS4082

antibody from Bioworld Technology, Inc
Targeting: GSK3A
Provider product page for BS4082
Western blot
Immunoprecipitation
Immunohistochemistry

Antibody data

Product number
BS4082 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS4082, RRID:AB_1664074
Product name
GSK3Ï« (phospho S21) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human GSK3Ï« around the phosphorylation site of Serine 21.
Description
Glycogen synthase kinase-3 Ï« and ÉÇ (GSK-3Ï«, ÉÇ) are serine/threonine kinases that regulate metabolic enzymes and transcription factors, which are responsible for coordinating processes such as glycogen synthesis and cell adhesion. GSK-3ÉÇ activity is also required for nuclear activity of Rel dimers, which mediate an anti-apoptotic response to TNFÏ« in mice. GSK-3 catalytic kinase activity is controlled through differential phosphorylation of serine/threonine residues, which have an inhibitory effect, and tyrosine residues, which have an activating effect. Growth factor stimulation of mammalian cells expressing GSK-3Ï« and GSK-3ÉÇ induces phosphorylation of Ser 21 and Ser 9, respectively through a phosphatidylinositol 3-kinase (PI 3-kinase)-protein kinase B (PKB) dependent pathway, thereby enhancing proliferative signals. Additionally, GSK-3 physically associates with cAMP-dependent protein kinase A (PKA), which phosphorylates Ser 21 of GSK-3Ï« or Ser 9 of GSK-3ÉÇ and inactivates both forms
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
GSK3A protein structure - BS4082 shown in red.