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Learn17449-1-AP
antibody from Proteintech Group
Targeting: HDAC4
BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, KIAA0288
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [18]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 17449-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17449-1-AP, RRID:AB_2118864
- Product name
- HDAC4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HDAC4 antibody (Cat. #17449-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Free fatty acid impairs myogenic differentiation through AMPKα-miR-206 pathway.
Transcriptomic Analysis of Glycolysis-Related Genes Reveals an Independent Signature of Bladder Carcinoma.
Transcriptional Factor Yin Yang 1 Promotes the Stemness of Breast Cancer Cells by Suppressing miR-873-5p Transcriptional Activity.
Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming.
Histone deacetylase 4 mediates high glucose-induced podocyte apoptosis via upregulation of calcineurin.
Resveratrol affects hepatic gluconeogenesis via histone deacetylase 4.
Expression of HDAC4 in Stage B Hepatocellular Carcinoma and Its Influence on Survival.
TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling.
The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction.
Hyper-acetylation contributes to the sensitivity of chemo-resistant prostate cancer cells to histone deacetylase inhibitor Trichostatin A.
Phosphatidylinositol 3-Kinase-DNA Methyltransferase 1-miR-1281-Histone Deacetylase 4 Regulatory Axis Mediates Platelet-Derived Growth Factor-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells.
Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner.
Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition.
Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1.
Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis.
Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.
MicroRNA directly enhances mitochondrial translation during muscle differentiation.
HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury.
Jiang A, Guo H, Zhang L, Jiang X, Zhang X, Wu W, Liu H
Molecular and cellular biology 2021 Oct 25;:MCB0032721
Molecular and cellular biology 2021 Oct 25;:MCB0032721
Transcriptomic Analysis of Glycolysis-Related Genes Reveals an Independent Signature of Bladder Carcinoma.
Mou Z, Yang C, Zhang Z, Wu S, Xu C, Cheng Z, Dai X, Chen X, Ou Y, Jiang H
Frontiers in genetics 2020;11:566918
Frontiers in genetics 2020;11:566918
Transcriptional Factor Yin Yang 1 Promotes the Stemness of Breast Cancer Cells by Suppressing miR-873-5p Transcriptional Activity.
Guo Q, Wang T, Yang Y, Gao L, Zhao Q, Zhang W, Xi T, Zheng L
Molecular therapy. Nucleic acids 2020 Sep 4;21:527-541
Molecular therapy. Nucleic acids 2020 Sep 4;21:527-541
Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming.
Feng S, Zhang L, Liu X, Li G, Zhang B, Wang Z, Zhang H, Ma H
Journal of cellular and molecular medicine 2020 Jul;24(14):7789-7801
Journal of cellular and molecular medicine 2020 Jul;24(14):7789-7801
Histone deacetylase 4 mediates high glucose-induced podocyte apoptosis via upregulation of calcineurin.
Shi W, Huang Y, Zhao X, Xie Z, Dong W, Li R, Chen Y, Li Z, Wang W, Ye Z, Liu S, Zhang L, Liang X
Biochemical and biophysical research communications 2020 Dec 17;533(4):1061-1068
Biochemical and biophysical research communications 2020 Dec 17;533(4):1061-1068
Resveratrol affects hepatic gluconeogenesis via histone deacetylase 4.
Zhao H, Shu L, Huang W, Song G, Ma H
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:401-411
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:401-411
Expression of HDAC4 in Stage B Hepatocellular Carcinoma and Its Influence on Survival.
Wang Z, Wang H, Shen P, Xie R
Annals of clinical and laboratory science 2019 Mar;49(2):189-192
Annals of clinical and laboratory science 2019 Mar;49(2):189-192
TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling.
Li J, Liu C, Li Y, Zheng Q, Xu Y, Liu B, Sun W, Li Y, Ji S, Liu M, Zhang J, Zhao D, Du R, Liu Z, Zhong G, Sun C, Wang Y, Song J, Zhang S, Qin J, Ling S, Wang X, Li Y
Nature communications 2019 Apr 8;10(1):1589
Nature communications 2019 Apr 8;10(1):1589
The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction.
He B, Dai L, Zhang X, Chen D, Wu J, Feng X, Zhang Y, Xie H, Zhou L, Wu J, Zheng S
International journal of biological sciences 2018;14(13):1845-1858
International journal of biological sciences 2018;14(13):1845-1858
Hyper-acetylation contributes to the sensitivity of chemo-resistant prostate cancer cells to histone deacetylase inhibitor Trichostatin A.
Xu Q, Liu X, Zhu S, Hu X, Niu H, Zhang X, Zhu D, Nesa EU, Tian K, Yuan H
Journal of cellular and molecular medicine 2018 Mar;22(3):1909-1922
Journal of cellular and molecular medicine 2018 Mar;22(3):1909-1922
Phosphatidylinositol 3-Kinase-DNA Methyltransferase 1-miR-1281-Histone Deacetylase 4 Regulatory Axis Mediates Platelet-Derived Growth Factor-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells.
Li Y, Li L, Qian Z, Lin B, Chen J, Luo Y, Qu J, Raj JU, Gou D
Journal of the American Heart Association 2018 Mar 7;7(6)
Journal of the American Heart Association 2018 Mar 7;7(6)
Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner.
Niu Y, Wang T, Liu S, Yuan H, Li H, Fu L
Biochimica et biophysica acta. Molecular basis of disease 2017 Sep;1863(9):2372-2381
Biochimica et biophysica acta. Molecular basis of disease 2017 Sep;1863(9):2372-2381
Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition.
Wang F, Zhao J, Liu D, Zhao T, Lu Z, Zhu L, Cao L, Yang J, Jin J, Cai Y
Cancer biology & therapy 2016 Nov;17(11):1117-1125
Cancer biology & therapy 2016 Nov;17(11):1117-1125
Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1.
Barbier-Torres L, Beraza N, Fernández-Tussy P, Lopitz-Otsoa F, Fernández-Ramos D, Zubiete-Franco I, Varela-Rey M, Delgado TC, Gutiérrez V, Anguita J, Pares A, Banales JM, Villa E, Caballería J, Alvarez L, Lu SC, Mato JM, Martínez-Chantar ML
Hepatology (Baltimore, Md.) 2015 Oct;62(4):1237-48
Hepatology (Baltimore, Md.) 2015 Oct;62(4):1237-48
Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis.
Cai M, Hu Z, Liu J, Gao J, Tan M, Zhang D, Zhu L, Liu S, Hou R, Lin B
Oncology reports 2015 Feb;33(2):685-92
Oncology reports 2015 Feb;33(2):685-92
Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.
Wang X, Liu J, Zhen J, Zhang C, Wan Q, Liu G, Wei X, Zhang Y, Wang Z, Han H, Xu H, Bao C, Song Z, Zhang X, Li N, Yi F
Kidney international 2014 Oct;86(4):712-25
Kidney international 2014 Oct;86(4):712-25
MicroRNA directly enhances mitochondrial translation during muscle differentiation.
Zhang X, Zuo X, Yang B, Li Z, Xue Y, Zhou Y, Huang J, Zhao X, Zhou J, Yan Y, Zhang H, Guo P, Sun H, Guo L, Zhang Y, Fu XD
Cell 2014 Jul 31;158(3):607-19
Cell 2014 Jul 31;158(3):607-19
HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury.
He M, Zhang B, Wei X, Wang Z, Fan B, Du P, Zhang Y, Jian W, Chen L, Wang L, Fang H, Li X, Wang PA, Yi F
Journal of cellular and molecular medicine 2013 Apr;17(4):531-42
Journal of cellular and molecular medicine 2013 Apr;17(4):531-42
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 17449-1-AP(HDAC4 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HDAC4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HDAC4. This antibody recognizes human,mouse,rat antigen. The HDAC4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
