BS6486

antibody from Bioworld Technology, Inc
Targeting: HDAC4 BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, KIAA0288
Provider product page for BS6486
Western blot
Immunocytochemistry
Immunoprecipitation
Immunohistochemistry
Chromatin Immunoprecipitation

Antibody data

Product number
BS6486 - Provider product page
Provider
Bioworld Technology, Inc
Product name
HDAC4 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human HDAC4.
Description
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation, and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, p300/CBP, PCAF (p300/CBPassociated factor), HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-6 have been identified as histone deacetylases.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
HDAC4 protein structure - BS6486 shown in red.