10478-2-AP

antibody from Proteintech Group

Targeting: IRAK1 IRAK, pelle

Provider product page for 10478-2-AP

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Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [18]
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Validations
Western blot [1]

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Product number: 10478-2-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10478-2-AP, RRID:AB_2126032
Product name: IRAK1 antibody
Antibody type: Polyclonal
Description: KD/KO validated IRAK1 antibody (Cat. #10478-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

IRAK1 protein structure - 10478-2-AP shown in red.

Submitted references Shenjinhuoxue Mixture Attenuates Inflammation, Pain, and Cartilage Degeneration by Inhibiting TLR-4 and NF-κB Activation in Rats with Osteoarthritis: A Synergistic Combination of Multitarget Active Phytochemicals.

Ma X, Hao C, Zhang Z, Jiang H, Zhang W, Huang J, Chen X, Yang W
Oxidative medicine and cellular longevity 2021;2021:4190098

Morchella importuna Flavones Improve Intestinal Integrity in Dextran Sulfate Sodium-Challenged Mice.

Xu Y, Xie L, Tang J, He X, Zhang Z, Chen Y, Zhou J, Gan B, Peng W
Frontiers in microbiology 2021;12:742033

Bone marrow mesenchymal stem cell-derived exosomes induce the Th17/Treg imbalance in immune thrombocytopenia through miR-146a-5p/IRAK1 axis.

He Y, Ji D, Lu W, Li F, Huang X, Huang R, Chen G
Human cell 2021 Sep;34(5):1360-1374

Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling.

Li H, Peng Y, Lin C, Zhang X, Zhang T, Wang Y, Li Y, Wu S, Wang H, Hutchinson MR, Watkins LR, Wang X
Innovation (New York, N.Y.) 2021 May 28;2(2):100111

Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation.

Xu G, Deng F, Zuo Q, Liu L, Dou K, Cheng Z, Cao W, Luo C, Yu C, Liu S, Zhu Y
Cellular & molecular immunology 2021 Jun;18(6):1587-1589

The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13.

Mulas F, Wang X, Song S, Nishanth G, Yi W, Brunn A, Larsen PK, Isermann B, Kalinke U, Barragan A, Naumann M, Deckert M, Schlüter D
Cellular & molecular immunology 2021 Jun;18(6):1512-1527

Cannabidiol-dihydroartemisinin conjugates for ameliorating neuroinflammation with reduced cytotoxicity.

Wang F, Li M, Lin C, Jin S, Li H, Lu Y, Wang H, Wang H, Wang X
Bioorganic & medicinal chemistry 2021 Jun 1;39:116131

MiR-146a mediates TLR-4 signaling pathway to affect myocardial fibrosis in rat constrictive pericarditis model.

Xiao Y, Qiao W, Wang X, Sun L, Ren W
Journal of thoracic disease 2021 Feb;13(2):935-945

Exosomes Derived from MicroRNA-146a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Alleviate Intracerebral Hemorrhage by Inhibiting Neuronal Apoptosis and Microglial M1 Polarization.

Duan S, Wang F, Cao J, Wang C
Drug design, development and therapy 2020;14:3143-3158

S100A14 suppresses metastasis of nasopharyngeal carcinoma by inhibition of NF-kB signaling through degradation of IRAK1.

Meng DF, Sun R, Liu GY, Peng LX, Zheng LS, Xie P, Lin ST, Mei Y, Qiang YY, Li CZ, Xu L, Peng XS, Hu H, Lang YH, Liu ZJ, Wang MD, Guo LL, Xie DH, Shu DT, Li HF, Luo FF, Niu XT, Huang BJ, Qian CN
Oncogene 2020 Jul;39(30):5307-5322

Quantification of Dynamic Protein Interactions and Phosphorylation in LPS Signaling Pathway by SWATH-MS.

Wu X, Yang D, Zhao F, Yang ZH, Wang D, Qiao M, Fang Y, Li W, Wu R, He P, Cong Y, Chen C, Hu L, Yan Y, Xie C, Wu Y, Han J, Zhong CQ
Molecular & cellular proteomics : MCP 2019 Jun;18(6):1054-1069

Sal B Alleviates Myocardial Ischemic Injury by Inhibiting TLR4 and the Priming Phase of NLRP3 Inflammasome.

Hu Y, Li Q, Pan Y, Xu L
Molecules (Basel, Switzerland) 2019 Dec 3;24(23)

Targeted delivery of microRNA 146b mimic to hepatocytes by lactosylated PDMAEMA nanoparticles for the treatment of NAFLD.

He S, Guo W, Deng F, Chen K, Jiang Y, Dong M, Peng L, Chen X
Artificial cells, nanomedicine, and biotechnology 2018;46(sup2):217-228

Capsular Polysaccharide is a Main Component of Mycoplasma ovipneumoniae in the Pathogen-Induced Toll-Like Receptor-Mediated Inflammatory Responses in Sheep Airway Epithelial Cells.

Jiang Z, Song F, Li Y, Xue D, Deng G, Li M, Liu X, Wang Y
Mediators of inflammation 2017;2017:9891673

Influence of the total saponin fraction from Dioscorea nipponica Makino on TLR2/4-IL1R receptor singnal pathway in rats of gouty arthritis.

Zhou Q, Lin FF, Liu SM, Sui XF
Journal of ethnopharmacology 2017 Jul 12;206:274-282

Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway.

Yao H, Hu C, Yin L, Tao X, Xu L, Qi Y, Han X, Xu Y, Zhao Y, Wang C, Peng J
International immunopharmacology 2016 Jul;36:132-141

Dysregulated expression of miR-146a contributes to age-related dysfunction of macrophages.

Jiang M, Xiang Y, Wang D, Gao J, Liu D, Liu Y, Liu S, Zheng D
Aging cell 2012 Feb;11(1):29-40

Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality.

Sun Y, Varambally S, Maher CA, Cao Q, Chockley P, Toubai T, Malter C, Nieves E, Tawara I, Wang Y, Ward PA, Chinnaiyan A, Reddy P
Blood 2011 Jun 9;117(23):6172-83

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The IRAK1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IRAK1. This antibody recognizes human,mouse,rat antigen. The IRAK1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 10478-2-AP.pdf

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