BS1541

antibody from Bioworld Technology, Inc

Targeting: IRAK1 IRAK, pelle

Immunocytochemistry

Antibody data

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Validation data

Product number: BS1541 - Provider product page
Provider: Bioworld Technology, Inc
Proper citation: Bioworld Technology Cat#BS1541, RRID:AB_1662696
Product name: IRAK1 (T381) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic peptide, corresponding to amino acids 350-400 of Human IRAK1.
Description: Three structurally related ligands for IL-1Rs have been described. These include two agonists, IL-1Ï« and IL-1ÉÇ, and a specific receptor antagonist, IL-1RÏ«. Two distinct receptors designated IL-1RI and IL-1RII have been identified, each of which belong to the Ig superfamily. The preponderance of evidence suggests IL-1RI to be the functional IL-1 receptor. Binding of IL-1 to its cognate receptor results in the activation of the NF°ÙB signaling pathway. The IL-1-dependent kinase termed IRAK (for IL-1 receptor-associated kinase) co-immunoprecipitates with activated IL-1RI and has been implicated as an upstream mediator of NF°ÙB activation. Additional support for this assertion comes from the fact that a related Drosophila protein, Pelle, is a known upstream activator of Dorsal, the Drosophila homolog of NF°ÙB.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

IRAK1 protein structure - BS1541 shown in red.