BS1760

antibody from Bioworld Technology, Inc
Targeting: IRAK1 IRAK, pelle
Provider product page for BS1760
Western blot
Immunohistochemistry

Antibody data

Product number
BS1760 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS1760, RRID:AB_1662849
Product name
IRAK1 (I205) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 180-220 of Human IRAK1.
Description
Three structurally related ligands for IL-1Rs have been described. These include two agonists, IL-1Ï« and IL-1ÉÇ, and a specific receptor antagonist, IL-1RÏ«. Two distinct receptors designated IL-1RI and IL-1RII have been identified, each of which belong to the Ig superfamily. The preponderance of evidence suggests IL-1RI to be the functional IL-1 receptor. Binding of IL-1 to its cognate receptor results in the activation of the NF°ÙB signaling pathway. The IL-1-dependent kinase termed IRAK (for IL-1 receptor-associated kinase) co-immunoprecipitates with activated IL-1RI and has been implicated as an upstream mediator of NF°ÙB activation. Additional support for this assertion comes from the fact that a related Drosophila protein, Pelle, is a known upstream activator of Dorsal, the Drosophila homolog of NF°ÙB.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
IRAK1 protein structure - BS1760 shown in red.