Ab111518

antibody from Aladdin Scientific Corporation

Targeting: MAPK8 JNK, JNK1, PRKM8, SAPK1

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

Ab111518

Provider

Aladdin Scientific Corporation

Product name

Recombinant JNK1 Antibody

Antibody type

Recombinant

Description

Rabbit anti Human JNK1 Antibody, Recombinant (R08-7H1), could be used for WB and so on.Application:WB: 1/500 - 1/1000ICC/IF: 1/50-1/200 Protein FunctionResponds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4). JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.Post-translationalDually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

AA 325-343


Antibody clone number

R08-7H1

Vial size

100μl,10μl,1ml,50μl

Concentration

1 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.