CABT-B114

antibody from Creative Diagnostics

Targeting: LRP6 ADCAD2

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

CABT-B114

Provider

Creative Diagnostics

Product name

Anti-LRP6 monoclonal antibody, clone 2D20

Antibody type

Monoclonal

Description

Low density lipoprotein receptor-related protein 6 (LRP6) is a member of the low density lipoprotein receptor gene family (LDLR). LRP6 a cell surface protein, plays a critical role in embryonic development by functioning as a co-receptor specifically for the ÉÇ-catenin Wnt signaling pathway. LRP6 is highly homologous and presents itself as a dimer in the cell membrane until it is phosphlorylated by Wnt. When LRP6 binds to Wnt, it phosphorylates Wnt at multiple sites, which results in the recruitment of the scaffolding protein Axin to the cell membrane and ÉÇ catenin activation. LRP6 is the receptor for a novel Wnt antaganoist, DKK1. LRP6 is associated with autosomal dominant coronary artery disease type 2 and bone formation, as well as many human malignancies.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

2D20

Vial size

100_g

Concentration

1 mg/mL

Storage

-20°C