PAB2306

antibody from Abnova Corporation

Targeting: PKD2 Pc-2, PC2, PKD4, TRPP2

Western blot (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

PAB2306

Provider

Abnova Corporation

Proper citation

Abnova Corporation Cat#PAB2306, RRID:AB_1578838

Product name

PKD2 polyclonal antibody

Antibody type

Polyclonal

Description

Rabbit polyclonal antibody raised against synthetic peptide of PKD2.

Storage

Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.

References

Submitted references

Elevated expression of mechanosensory polycystins in human carotid atherosclerotic plaques: association with p53 activation and disease severity.

Varela A, Piperi C, Sigala F, Agrogiannis G, Davos CH, Andri MA, Manopoulos C, Tsangaris S, Basdra EK, Papavassiliou AG
Scientific reports 2015 Aug 19;5:13461

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Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer.

Gargalionis AN, Korkolopoulou P, Farmaki E, Piperi C, Dalagiorgou G, Adamopoulos C, Levidou G, Saetta A, Fragkou P, Tsioli P, Kiaris H, Zizi-Serbetzoglou A, Karavokyros I, Papavassiliou KA, Tsavaris N, Patsouris E, Basdra EK, Papavassiliou AG
International journal of cancer 2015 Apr 1;136(7):1515-27

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Polycystin channels and kidney disease.

Stayner C, Zhou J
Trends in pharmacological sciences 2001 Nov;22(11):543-6

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In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2.

Lehtonen S, Ora A, Olkkonen VM, Geng L, Zerial M, Somlo S, Lehtonen E
The Journal of biological chemistry 2000 Oct 20;275(42):32888-93

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Mutations of PKD1 in ADPKD2 cysts suggest a pathogenic effect of trans-heterozygous mutations.

Watnick T, He N, Wang K, Liang Y, Parfrey P, Hefferton D, St George-Hyslop P, Germino G, Pei Y
Nature genetics 2000 Jun;25(2):143-4

Western blot

Supportive validation

Submitted by

Abnova Corporation (provider)

Main image

Experimental details

The PKD2 polyclonal antibody (Cat # PAB2306) is used in Western blot to detect PKD2 in HL-60 cell lysate.

Immunohistochemistry

Supportive validation

Submitted by

Abnova Corporation (provider)

Main image

Experimental details

Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with the PKD2 polyclonal antibody (Cat # PAB2306) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.

Validation comment

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)