Antibody data
- Antibody Data
- Antigen structure
- References [32]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 11117-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11117-1-AP, RRID:AB_2210113
- Product name
- TXNRD1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TXNRD1 antibody (Cat. #11117-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Selenium Deficiency Leads to Changes in Renal Fibrosis Marker Proteins and Wnt/β-Catenin Signaling Pathway Components.
Therapeutic Effects of an Inhibitor of Thioredoxin Reductase on Liver Fibrosis by Inhibiting the Transforming Growth Factor-β1/Smads Pathway.
Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells.
Mechanistic Analysis of an Extracellular Signal-Regulated Kinase 2-Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress.
Libertellenone H, a Natural Pimarane Diterpenoid, Inhibits Thioredoxin System and Induces ROS-Mediated Apoptosis in Human Pancreatic Cancer Cells.
Discovery of hydroxytyrosol as thioredoxin reductase 1 inhibitor to induce apoptosis and G1/S cell cycle arrest in human colorectal cancer cells via ROS generation.
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
WHSC1 Promotes Cell Proliferation, Migration, and Invasion in Hepatocellular Carcinoma by Activating mTORC1 Signaling.
Synthesis and biological evaluation of gold(III) Schiff base complexes for the treatment of hepatocellular carcinoma through attenuating TrxR activity.
Synthesis and biological evaluation of myricetin-pentadienone hybrids as potential anti-inflammatory agents in vitro and in vivo.
A Gold(I) Complex Containing an Oleanolic Acid Derivative as a Potential Anti-Ovarian-Cancer Agent by Inhibiting TrxR and Activating ROS-Mediated ERS.
Targeting the MAPK/ERK and PI3K/AKT Signaling Pathways Affects NRF2, Trx and GSH Antioxidant Systems in Leukemia Cells.
The novel thioredoxin reductase inhibitor A-Z2 triggers intrinsic apoptosis and shows efficacy in the treatment of acute myeloid leukemia.
Design, synthesis, and biological evaluation of a novel indoleamine 2,3-dioxigenase 1 (IDO1) and thioredoxin reductase (TrxR) dual inhibitor.
miR-125b-5p inhibits cell proliferation, migration, and invasion in hepatocellular carcinoma via targeting TXNRD1.
Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors.
A novel iron(II) phenanthroline complex exhibits anticancer activity against TFR1-overexpressing esophageal squamous cell carcinoma cells through ROS accumulation and DNA damage.
Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.
Golgi stress mediates redox imbalance and ferroptosis in human cells.
Knockdown of Trnau1ap inhibits the proliferation and migration of NIH3T3, JEG-3 and Bewo cells via the PI3K/Akt signaling pathway.
Inhibition of NRF2 signaling and increased reactive oxygen species during embryogenesis in a rat model of retinoic acid-induced neural tube defects.
Aberrant expression of redox regulatory proteins in patients with concomitant primary Sclerosing cholangitis/inflammatory bowel disease.
Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity.
Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.
Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress.
The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways.
Translational regulation of GPx-1 and GPx-4 by the mTOR pathway.
Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice.
Natural allelic variations in glutathione peroxidase-1 affect its subcellular localization and function.
Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma.
Overexpression of thioredoxin system proteins predicts poor prognosis in patients with squamous cell carcinoma of the tongue.
Nucleolin binds to a subset of selenoprotein mRNAs and regulates their expression.
Lin T, Tao J, Chen Y, Zhang Y, Li F, Zhang Y, Han X, Zhao Z, Liu G, Li H
Biological trace element research 2022 Mar;200(3):1127-1139
Biological trace element research 2022 Mar;200(3):1127-1139
Therapeutic Effects of an Inhibitor of Thioredoxin Reductase on Liver Fibrosis by Inhibiting the Transforming Growth Factor-β1/Smads Pathway.
Jiao W, Bai M, Yin H, Liu J, Sun J, Su X, Zeng H, Wen J
Frontiers in molecular biosciences 2021;8:690170
Frontiers in molecular biosciences 2021;8:690170
Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells.
Yang M, Zhang W, Yu X, Wang F, Li Y, Zhang Y, Yang Y
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 14;27:e930083
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 14;27:e930083
Mechanistic Analysis of an Extracellular Signal-Regulated Kinase 2-Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress.
Martinez R 3rd, Huang W, Samadani R, Mackowiak B, Centola G, Chen L, Conlon IL, Hom K, Kane MA, Fletcher S, Shapiro P
The Journal of pharmacology and experimental therapeutics 2021 Jan;376(1):84-97
The Journal of pharmacology and experimental therapeutics 2021 Jan;376(1):84-97
Libertellenone H, a Natural Pimarane Diterpenoid, Inhibits Thioredoxin System and Induces ROS-Mediated Apoptosis in Human Pancreatic Cancer Cells.
Zhang W, Zhu Y, Yu H, Liu X, Jiao B, Lu X
Molecules (Basel, Switzerland) 2021 Jan 9;26(2)
Molecules (Basel, Switzerland) 2021 Jan 9;26(2)
Discovery of hydroxytyrosol as thioredoxin reductase 1 inhibitor to induce apoptosis and G1/S cell cycle arrest in human colorectal cancer cells via ROS generation.
Zhang SP, Zhou J, Fan QZ, Lv XM, Wang T, Wang F, Chen Y, Hong SY, Liu XP, Xu BS, Hu L, Zhang C, Zhang YM
Experimental and therapeutic medicine 2021 Aug;22(2):829
Experimental and therapeutic medicine 2021 Aug;22(2):829
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
Qi J, Chen X, Wu Q, Wang J, Zhang H, Mao A, Zhu M, Miao C
Oxidative medicine and cellular longevity 2020;2020:3985089
Oxidative medicine and cellular longevity 2020;2020:3985089
WHSC1 Promotes Cell Proliferation, Migration, and Invasion in Hepatocellular Carcinoma by Activating mTORC1 Signaling.
Dai J, Jiang L, Qiu L, Shao Y, Shi P, Li J
OncoTargets and therapy 2020;13:7033-7044
OncoTargets and therapy 2020;13:7033-7044
Synthesis and biological evaluation of gold(III) Schiff base complexes for the treatment of hepatocellular carcinoma through attenuating TrxR activity.
Bian M, Wang X, Sun Y, Liu W
European journal of medicinal chemistry 2020 May 1;193:112234
European journal of medicinal chemistry 2020 May 1;193:112234
Synthesis and biological evaluation of myricetin-pentadienone hybrids as potential anti-inflammatory agents in vitro and in vivo.
Liu C, Han X, Yu PJ, Chen LZ, Xue W, Liu XH
Bioorganic chemistry 2020 Mar;96:103597
Bioorganic chemistry 2020 Mar;96:103597
A Gold(I) Complex Containing an Oleanolic Acid Derivative as a Potential Anti-Ovarian-Cancer Agent by Inhibiting TrxR and Activating ROS-Mediated ERS.
Bian M, Sun Y, Liu Y, Xu Z, Fan R, Liu Z, Liu W
Chemistry (Weinheim an der Bergstrasse, Germany) 2020 Jun 2;26(31):7092-7108
Chemistry (Weinheim an der Bergstrasse, Germany) 2020 Jun 2;26(31):7092-7108
Targeting the MAPK/ERK and PI3K/AKT Signaling Pathways Affects NRF2, Trx and GSH Antioxidant Systems in Leukemia Cells.
Jasek-Gajda E, Jurkowska H, Jasińska M, Lis GJ
Antioxidants (Basel, Switzerland) 2020 Jul 17;9(7)
Antioxidants (Basel, Switzerland) 2020 Jul 17;9(7)
The novel thioredoxin reductase inhibitor A-Z2 triggers intrinsic apoptosis and shows efficacy in the treatment of acute myeloid leukemia.
Zhang D, Liu Y, Luo Z, Chen Y, Xu A, Liang Y, Wu B, Tong X, Liu X, Shen H, Liu L, Wei Y, Zhou H, Liu Y, Zhou F
Free radical biology & medicine 2020 Jan;146:275-286
Free radical biology & medicine 2020 Jan;146:275-286
Design, synthesis, and biological evaluation of a novel indoleamine 2,3-dioxigenase 1 (IDO1) and thioredoxin reductase (TrxR) dual inhibitor.
Fan QZ, Zhou J, Zhu YB, He LJ, Miao DD, Zhang SP, Liu XP, Zhang C
Bioorganic chemistry 2020 Dec;105:104401
Bioorganic chemistry 2020 Dec;105:104401
miR-125b-5p inhibits cell proliferation, migration, and invasion in hepatocellular carcinoma via targeting TXNRD1.
Hua S, Quan Y, Zhan M, Liao H, Li Y, Lu L
Cancer cell international 2019;19:203
Cancer cell international 2019;19:203
Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors.
Sparaneo A, Fabrizio FP, la Torre A, Graziano P, Di Maio M, Fontana A, Bisceglia M, Rossi A, Pizzolitto S, De Maglio G, Tancredi A, Grimaldi F, Balsamo T, Centra F, Manzorra MC, Trombetta D, Pantalone A, Bonfitto A, Maiello E, Fazio VM, Muscarella LA
International journal of molecular sciences 2019 May 23;20(10)
International journal of molecular sciences 2019 May 23;20(10)
A novel iron(II) phenanthroline complex exhibits anticancer activity against TFR1-overexpressing esophageal squamous cell carcinoma cells through ROS accumulation and DNA damage.
Ye J, Ma J, Liu C, Huang J, Wang L, Zhong X
Biochemical pharmacology 2019 Aug;166:93-107
Biochemical pharmacology 2019 Aug;166:93-107
Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.
Maryam A, Mehmood T, Yan Q, Li Y, Khan M, Ma T
Oxidative medicine and cellular longevity 2018;2018:3853409
Oxidative medicine and cellular longevity 2018;2018:3853409
Golgi stress mediates redox imbalance and ferroptosis in human cells.
Alborzinia H, Ignashkova TI, Dejure FR, Gendarme M, Theobald J, Wölfl S, Lindemann RK, Reiling JH
Communications biology 2018;1:210
Communications biology 2018;1:210
Knockdown of Trnau1ap inhibits the proliferation and migration of NIH3T3, JEG-3 and Bewo cells via the PI3K/Akt signaling pathway.
Hu X, Luo J, Lai H, Li M, Zheng X, Nie T, Li F, Li H
Biochemical and biophysical research communications 2018 Sep 5;503(2):521-527
Biochemical and biophysical research communications 2018 Sep 5;503(2):521-527
Inhibition of NRF2 signaling and increased reactive oxygen species during embryogenesis in a rat model of retinoic acid-induced neural tube defects.
Liu D, Xue J, Liu Y, Gu H, Wei X, Ma W, Luo W, Ma L, Jia S, Dong N, Huang J, Wang Y, Yuan Z
Neurotoxicology 2018 Dec;69:84-92
Neurotoxicology 2018 Dec;69:84-92
Aberrant expression of redox regulatory proteins in patients with concomitant primary Sclerosing cholangitis/inflammatory bowel disease.
Petersen DR, Orlicky DJ, Roede JR, Shearn CT
Experimental and molecular pathology 2018 Aug;105(1):32-36
Experimental and molecular pathology 2018 Aug;105(1):32-36
Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity.
Zheng X, Ma W, Sun R, Yin H, Lin F, Liu Y, Xu W, Zeng H
Redox biology 2018 Apr;14:237-249
Redox biology 2018 Apr;14:237-249
Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.
Mehmood T, Maryam A, Tian X, Khan M, Ma T
Journal of Cancer 2017;8(18):3707-3717
Journal of Cancer 2017;8(18):3707-3717
Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress.
Maryam A, Mehmood T, Zhang H, Li Y, Khan M, Ma T
Scientific reports 2017 Jul 24;7(1):6242
Scientific reports 2017 Jul 24;7(1):6242
The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways.
Chen X, Zhao X, Cai H, Sun H, Hu Y, Huang X, Kong W, Kong W
Redox biology 2017 Aug;12:987-1003
Redox biology 2017 Aug;12:987-1003
Translational regulation of GPx-1 and GPx-4 by the mTOR pathway.
Reinke EN, Ekoue DN, Bera S, Mahmud N, Diamond AM
PloS one 2014;9(4):e93472
PloS one 2014;9(4):e93472
Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice.
Brown-Borg HM, Rakoczy S, Wonderlich JA, Armstrong V, Rojanathammanee L
Longevity & healthspan 2014;3(1):10
Longevity & healthspan 2014;3(1):10
Natural allelic variations in glutathione peroxidase-1 affect its subcellular localization and function.
Bera S, Weinberg F, Ekoue DN, Ansenberger-Fricano K, Mao M, Bonini MG, Diamond AM
Cancer research 2014 Sep 15;74(18):5118-26
Cancer research 2014 Sep 15;74(18):5118-26
Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma.
Iwasawa S, Yamano Y, Takiguchi Y, Tanzawa H, Tatsumi K, Uzawa K
Oncology reports 2011 Mar;25(3):637-44
Oncology reports 2011 Mar;25(3):637-44
Overexpression of thioredoxin system proteins predicts poor prognosis in patients with squamous cell carcinoma of the tongue.
Zhu X, Huang C, Peng B
Oral oncology 2011 Jul;47(7):609-14
Oral oncology 2011 Jul;47(7):609-14
Nucleolin binds to a subset of selenoprotein mRNAs and regulates their expression.
Miniard AC, Middleton LM, Budiman ME, Gerber CA, Driscoll DM
Nucleic acids research 2010 Aug;38(14):4807-20
Nucleic acids research 2010 Aug;38(14):4807-20
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 11117-1-AP(TXNRD1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using TXNRD1 antibody 11117-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-TXNRD1 (IP:11117-1-AP, 3ug; Detection:11117-1-AP 1:500) with Jurkat cells lysate 1500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 11117-1-AP(TXNRD1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue