Antibody data
- Antibody Data
- Antigen structure
- References [39]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
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Validation data
Reference
Comment
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- Product number
- 11071-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11071-1-AP, RRID:AB_2066528
- Product name
- CA9 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CA9 antibody (Cat. #11071-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A carbonic anhydrase-targeted NIR-II fluorescent cisplatin theranostic nanoparticle for combined therapy of pancreatic tumors.
GSH/pH Dual Activatable Cross-linked and Fluorinated PEI for Cancer Gene Therapy Through Endogenous Iron De-Hijacking and in Situ ROS Amplification.
Glucagon Enhances Chemotherapy Efficacy By Inhibition of Tumor Vessels in Colorectal Cancer.
Pathway-based stratification of gliomas uncovers four subtypes with different TME characteristics and prognosis.
Carbonic Anhydrase IX Controls Vulnerability to Ferroptosis in Gefitinib-Resistant Lung Cancer.
Arenobufagin increases the sensitivity of gastric cancer to cisplatin via alkaliptosis.
Para-toluenesulfonamide, a novel potent carbonic anhydrase inhibitor, improves hypoxia-induced metastatic breast cancer cell viability and prevents resistance to αPD-1 therapy in triple-negative breast cancer.
KCNJ2/HIF1α positive-feedback loop promotes the metastasis of osteosarcoma.
Effect of isorhamnetin on carbonic anhydrase IX expression and tumorigenesis of bladder cancer by activating PPARγ/PTEN/AKT pathway.
Targeting endothelial coagulation signaling ameliorates liver obstructive cholestasis and dysfunctional angiogenesis.
Targeting Tumor Hypoxia Inhibits Aggressive Phenotype of Dedifferentiated Thyroid Cancer.
HIF1α/VEGF Feedback Loop Contributes to 5-Fluorouracil Resistance.
Anti-tumor effects of P-LPK-CPT, a peptide-camptothecin conjugate, in colorectal cancer.
A novel hypoxia-driven gene signature that can predict the prognosis of hepatocellular carcinoma.
The Immunological Contribution of a Novel Metabolism-Related Signature to the Prognosis and Anti-Tumor Immunity in Cervical Cancer.
An Original Aspirin-Containing Carbonic Anhydrase 9 Inhibitor Overcomes Hypoxia-Induced Drug Resistance to Enhance the Efficacy of Myocardial Protection.
Lenvatinib for effectively treating antiangiogenic drug-resistant nasopharyngeal carcinoma.
A functional role of S100A4/non-muscle myosin IIA axis for pro-tumorigenic vascular functions in glioblastoma.
Matrine injection inhibits pancreatic cancer growth via modulating carbonic anhydrases- a network pharmacology-based study with in vitro validation.
Hypoxia Stimulates SUMOylation-Dependent Stabilization of KDM5B.
Targeting the Ang2/Tie2 Axis with Tanshinone IIA Elicits Vascular Normalization in Ischemic Injury and Colon Cancer.
Decreased Portal Circulation Augments Fibrosis and Ductular Reaction in Nonalcoholic Fatty Liver Disease in Mice.
Ginsenoside CK Inhibits Hypoxia-Induced Epithelial-Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma.
Targeting Hypoxic Tumors with Hybrid Nanobullets for Oxygen-Independent Synergistic Photothermal and Thermodynamic Therapy.
In vivo three-dimensional evaluation of tumour hypoxia in nasopharyngeal carcinomas using FMT-CT and MSOT.
Using ESTIMATE algorithm to establish an 8-mRNA signature prognosis prediction system and identify immunocyte infiltration-related genes in Pancreatic adenocarcinoma.
Requirements of LEFTY and Nodal overexpression for tumor cell survival under hypoxia in glioblastoma.
Enhanced Glycogen Metabolism Supports the Survival and Proliferation of HPV-Infected Keratinocytes in Condylomata Acuminata.
Correlation between maximum standardized uptake values on FDG-PET and microenvironmental factors in patients with clinical stage IA radiologic pure-solid lung adenocarcinoma.
Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression.
Comprehensive analysis of differentially expressed non-coding RNAs and mRNAs in gastric cancer cells under hypoxic conditions.
Differences of tumor microenvironment between stage I lepidic-positive and lepidic-negative lung adenocarcinomas.
Abundant tumor promoting stromal cells in lung adenocarcinoma with hypoxic regions.
Loss of Phd2 cooperates with BRAF(V600E) to drive melanomagenesis.
Succinate dehydrogenase B-deficient renal cell carcinoma: A case report with novel germline mutation.
CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing.
The Ketogenic Diet Alters the Hypoxic Response and Affects Expression of Proteins Associated with Angiogenesis, Invasive Potential and Vascular Permeability in a Mouse Glioma Model.
Fructose-2,6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth.
Necrosis degree displayed in computed tomography images correlated with hypoxia and angiogenesis in breast cancer.
Yang Y, Liu Y, Weng J, Wen X, Liu Y, Ye D
Biomaterials 2024 Mar;305:122454
Biomaterials 2024 Mar;305:122454
GSH/pH Dual Activatable Cross-linked and Fluorinated PEI for Cancer Gene Therapy Through Endogenous Iron De-Hijacking and in Situ ROS Amplification.
Yang S, Wu Y, Zhong W, Chen R, Wang M, Chen M
Advanced materials (Deerfield Beach, Fla.) 2024 Jan;36(2):e2304098
Advanced materials (Deerfield Beach, Fla.) 2024 Jan;36(2):e2304098
Glucagon Enhances Chemotherapy Efficacy By Inhibition of Tumor Vessels in Colorectal Cancer.
Xu Y, Ni F, Sun D, Peng Y, Zhao Y, Wu X, Li S, Qi X, He X, Li M, Zhou Y, Zhang C, Yan M, Yao C, Zhu S, Yang Y, An B, Yang C, Zhang G, Jiang W, Mi J, Chen X, Wei P, Tian G, Zhang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(6):e2307271
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(6):e2307271
Pathway-based stratification of gliomas uncovers four subtypes with different TME characteristics and prognosis.
Huang R, Han B, Zhang Y, Yang J, Wang K, Liu X, Wang Z
Journal of cellular and molecular medicine 2024 Apr;28(8):e18208
Journal of cellular and molecular medicine 2024 Apr;28(8):e18208
Carbonic Anhydrase IX Controls Vulnerability to Ferroptosis in Gefitinib-Resistant Lung Cancer.
Zhang C, Lu X, Liu X, Xu J, Li J, Qu T, Dai J, Guo R
Oxidative medicine and cellular longevity 2023;2023:1367938
Oxidative medicine and cellular longevity 2023;2023:1367938
Arenobufagin increases the sensitivity of gastric cancer to cisplatin via alkaliptosis.
Liu C, Li D, Wang J, Wang Z
Heliyon 2023 Nov;9(11):e21110
Heliyon 2023 Nov;9(11):e21110
Para-toluenesulfonamide, a novel potent carbonic anhydrase inhibitor, improves hypoxia-induced metastatic breast cancer cell viability and prevents resistance to αPD-1 therapy in triple-negative breast cancer.
Chen HY, Lin CE, Wu SC, Yang ZY, Chiang YF, Huang KC, Wang KL, Ali M, Shieh TM, Chang HY, Huang TC, Hsia SM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115533
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115533
KCNJ2/HIF1α positive-feedback loop promotes the metastasis of osteosarcoma.
Shen M, Pan R, Lei S, Zhang L, Zhou C, Zeng Z, Nie Y, Tian X
Cell communication and signaling : CCS 2023 Mar 2;21(1):46
Cell communication and signaling : CCS 2023 Mar 2;21(1):46
Effect of isorhamnetin on carbonic anhydrase IX expression and tumorigenesis of bladder cancer by activating PPARγ/PTEN/AKT pathway.
Zhang P, Sun Y, Shi L, Sun D, Wang L, Feng D, Ding C
Tissue & cell 2023 Jun;82:102048
Tissue & cell 2023 Jun;82:102048
Targeting endothelial coagulation signaling ameliorates liver obstructive cholestasis and dysfunctional angiogenesis.
Yang X, Ou Y, Yang Y, Wang L, Zhang Y, Zhao F, Shui P, Qing J
Experimental biology and medicine (Maywood, N.J.) 2023 Jul;248(14):1242-1253
Experimental biology and medicine (Maywood, N.J.) 2023 Jul;248(14):1242-1253
Targeting Tumor Hypoxia Inhibits Aggressive Phenotype of Dedifferentiated Thyroid Cancer.
Ma B, Wen S, Luo Y, Zhang T, Yang Y, Shen C, Zhang Y, Ji Q, Qu N, Wang Y
The Journal of clinical endocrinology and metabolism 2023 Jan 17;108(2):368-384
The Journal of clinical endocrinology and metabolism 2023 Jan 17;108(2):368-384
HIF1α/VEGF Feedback Loop Contributes to 5-Fluorouracil Resistance.
Shi B, Xu FF, Xiang CP, Li CY, Fan P, Wang H
Frontiers in pharmacology 2022;13:851401
Frontiers in pharmacology 2022;13:851401
Anti-tumor effects of P-LPK-CPT, a peptide-camptothecin conjugate, in colorectal cancer.
Hou L, Hou Y, Liang Y, Chen B, Zhang X, Wang Y, Zhou K, Zhong T, Long B, Pang W, Wang L, Han X, Li L, Xu C, Gross I, Gaiddon C, Fu W, Yao H, Meng X
Communications biology 2022 Nov 14;5(1):1248
Communications biology 2022 Nov 14;5(1):1248
A novel hypoxia-driven gene signature that can predict the prognosis of hepatocellular carcinoma.
Zeng Z, Lei S, Wang J, Yang Y, Lan J, Tian Q, Chen T, Hao X
Bioengineered 2022 May;13(5):12193-12210
Bioengineered 2022 May;13(5):12193-12210
The Immunological Contribution of a Novel Metabolism-Related Signature to the Prognosis and Anti-Tumor Immunity in Cervical Cancer.
Yu S, Li X, Ma M, Yang R, Zhang J, Wu S
Cancers 2022 May 13;14(10)
Cancers 2022 May 13;14(10)
An Original Aspirin-Containing Carbonic Anhydrase 9 Inhibitor Overcomes Hypoxia-Induced Drug Resistance to Enhance the Efficacy of Myocardial Protection.
Zhou W, Zhang B, Fan K, Yin X, Liu J, Gou S
Cardiovascular drugs and therapy 2022 Aug;36(4):605-618
Cardiovascular drugs and therapy 2022 Aug;36(4):605-618
Lenvatinib for effectively treating antiangiogenic drug-resistant nasopharyngeal carcinoma.
Sun Q, Wang Y, Ji H, Sun X, Xie S, Chen L, Li S, Zeng W, Chen R, Tang Q, Zuo J, Hou L, Hosaka K, Lu Y, Liu Y, Ye Y, Yang Y
Cell death & disease 2022 Aug 19;13(8):724
Cell death & disease 2022 Aug 19;13(8):724
A functional role of S100A4/non-muscle myosin IIA axis for pro-tumorigenic vascular functions in glioblastoma.
Inukai M, Yokoi A, Ishizuka Y, Hashimura M, Matsumoto T, Oguri Y, Nakagawa M, Ishibashi Y, Ito T, Kumabe T, Saegusa M
Cell communication and signaling : CCS 2022 Apr 7;20(1):46
Cell communication and signaling : CCS 2022 Apr 7;20(1):46
Matrine injection inhibits pancreatic cancer growth via modulating carbonic anhydrases- a network pharmacology-based study with in vitro validation.
Xu PL, Cheng CS, Jiao JY, Chen H, Chen Z, Li P
Journal of ethnopharmacology 2022 Apr 6;287:114691
Journal of ethnopharmacology 2022 Apr 6;287:114691
Hypoxia Stimulates SUMOylation-Dependent Stabilization of KDM5B.
Zhou B, Zhu Y, Xu W, Zhou Q, Tan L, Zhu L, Chen H, Feng L, Hou T, Wang X, Chen D, Jin H
Frontiers in cell and developmental biology 2021;9:741736
Frontiers in cell and developmental biology 2021;9:741736
Targeting the Ang2/Tie2 Axis with Tanshinone IIA Elicits Vascular Normalization in Ischemic Injury and Colon Cancer.
Zou W, Qian C, Zhang S, Wan X, Wei Z, Li X, Wu Y, Chen W, Wang A, Zhao Y, Lu Y
Oxidative medicine and cellular longevity 2021;2021:7037786
Oxidative medicine and cellular longevity 2021;2021:7037786
Decreased Portal Circulation Augments Fibrosis and Ductular Reaction in Nonalcoholic Fatty Liver Disease in Mice.
Meng L, Goto M, Tanaka H, Kamikokura Y, Fujii Y, Okada Y, Furukawa H, Nishikawa Y
The American journal of pathology 2021 Sep;191(9):1580-1591
The American journal of pathology 2021 Sep;191(9):1580-1591
Ginsenoside CK Inhibits Hypoxia-Induced Epithelial-Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma.
Zhang J, Ma X, Fan D
Foods (Basel, Switzerland) 2021 May 26;10(6)
Foods (Basel, Switzerland) 2021 May 26;10(6)
Targeting Hypoxic Tumors with Hybrid Nanobullets for Oxygen-Independent Synergistic Photothermal and Thermodynamic Therapy.
Gao D, Chen T, Chen S, Ren X, Han Y, Li Y, Wang Y, Guo X, Wang H, Chen X, Guo M, Zhang YS, Hong G, Zhang X, Tian Z, Yang Z
Nano-micro letters 2021 Mar 31;13(1):99
Nano-micro letters 2021 Mar 31;13(1):99
In vivo three-dimensional evaluation of tumour hypoxia in nasopharyngeal carcinomas using FMT-CT and MSOT.
Huang W, Wang K, An Y, Meng H, Gao Y, Xiong Z, Yan H, Wang Q, Cai X, Yang X, Zhang B, Chen Q, Yang X, Tian J, Zhang S
European journal of nuclear medicine and molecular imaging 2020 May;47(5):1027-1038
European journal of nuclear medicine and molecular imaging 2020 May;47(5):1027-1038
Using ESTIMATE algorithm to establish an 8-mRNA signature prognosis prediction system and identify immunocyte infiltration-related genes in Pancreatic adenocarcinoma.
Meng Z, Ren D, Zhang K, Zhao J, Jin X, Wu H
Aging 2020 Mar 17;12(6):5048-5070
Aging 2020 Mar 17;12(6):5048-5070
Requirements of LEFTY and Nodal overexpression for tumor cell survival under hypoxia in glioblastoma.
Matsumoto T, Chino H, Akiya M, Hashimura M, Yokoi A, Tochimoto M, Nakagawa M, Jiang Z, Saegusa M
Molecular carcinogenesis 2020 Dec;59(12):1409-1419
Molecular carcinogenesis 2020 Dec;59(12):1409-1419
Enhanced Glycogen Metabolism Supports the Survival and Proliferation of HPV-Infected Keratinocytes in Condylomata Acuminata.
Gu Z, Zhang H, Guo X, Cao Y
The Journal of investigative dermatology 2020 Aug;140(8):1513-1523.e5
The Journal of investigative dermatology 2020 Aug;140(8):1513-1523.e5
Correlation between maximum standardized uptake values on FDG-PET and microenvironmental factors in patients with clinical stage IA radiologic pure-solid lung adenocarcinoma.
Ichikawa T, Aokage K, Miyoshi T, Tane K, Suzuki K, Makinoshima H, Tsuboi M, Ishii G
Lung cancer (Amsterdam, Netherlands) 2019 Oct;136:57-64
Lung cancer (Amsterdam, Netherlands) 2019 Oct;136:57-64
Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression.
Li JM, Jiang GM, Zhao L, Yang F, Yuan WQ, Wang H, Luo YQ
Oncology reports 2019 Nov;42(5):1725-1734
Oncology reports 2019 Nov;42(5):1725-1734
Comprehensive analysis of differentially expressed non-coding RNAs and mRNAs in gastric cancer cells under hypoxic conditions.
Li J, Wang X, Lu W, Xiao Y, Yu Y, Wang X, Xu C, Shen B
American journal of translational research 2018;10(3):1022-1035
American journal of translational research 2018;10(3):1022-1035
Differences of tumor microenvironment between stage I lepidic-positive and lepidic-negative lung adenocarcinomas.
Katsumata S, Aokage K, Miyoshi T, Tane K, Nakamura H, Sugano M, Kojima M, Fujii S, Kuwata T, Ochiai A, Hayashi R, Tsuboi M, Ishii G
The Journal of thoracic and cardiovascular surgery 2018 Oct;156(4):1679-1688.e2
The Journal of thoracic and cardiovascular surgery 2018 Oct;156(4):1679-1688.e2
Abundant tumor promoting stromal cells in lung adenocarcinoma with hypoxic regions.
Nakamura H, Ichikawa T, Nakasone S, Miyoshi T, Sugano M, Kojima M, Fujii S, Ochiai A, Kuwata T, Aokage K, Suzuki K, Tsuboi M, Ishii G
Lung cancer (Amsterdam, Netherlands) 2018 Jan;115:56-63
Lung cancer (Amsterdam, Netherlands) 2018 Jan;115:56-63
Loss of Phd2 cooperates with BRAF(V600E) to drive melanomagenesis.
Liu S, Zhang G, Guo J, Chen X, Lei J, Ze K, Dong L, Dai X, Gao Y, Song D, Ecker BL, Yang R, Feltcher C, Peng K, Feng C, Chen H, Lee RX, Kerestes H, Niu J, Kumar S, Xu W, Zhang J, Wei Z, Martin JS, Liu X, Mills G, Lu Y, Guo W, Sun L, Zhang L, Weeraratna A, Herlyn M, Wei W, Lee FS, Xu X
Nature communications 2018 Dec 21;9(1):5426
Nature communications 2018 Dec 21;9(1):5426
Succinate dehydrogenase B-deficient renal cell carcinoma: A case report with novel germline mutation.
Iwashita H, Okudela K, Matsumura M, Yamanaka S, Sawazumi T, Enaka M, Udaka N, Miyake A, Hibiya T, Miyake N, Matsumoto N, Makiyama K, Yao M, Nagashima Y, Ohashi K
Pathology international 2017 Nov;67(11):585-589
Pathology international 2017 Nov;67(11):585-589
CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing.
Clark AJ, Wiley DT, Zuckerman JE, Webster P, Chao J, Lin J, Yen Y, Davis ME
Proceedings of the National Academy of Sciences of the United States of America 2016 Apr 5;113(14):3850-4
Proceedings of the National Academy of Sciences of the United States of America 2016 Apr 5;113(14):3850-4
The Ketogenic Diet Alters the Hypoxic Response and Affects Expression of Proteins Associated with Angiogenesis, Invasive Potential and Vascular Permeability in a Mouse Glioma Model.
Woolf EC, Curley KL, Liu Q, Turner GH, Charlton JA, Preul MC, Scheck AC
PloS one 2015;10(6):e0130357
PloS one 2015;10(6):e0130357
Fructose-2,6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth.
Chesney J, Clark J, Klarer AC, Imbert-Fernandez Y, Lane AN, Telang S
Oncotarget 2014 Aug 30;5(16):6670-86
Oncotarget 2014 Aug 30;5(16):6670-86
Necrosis degree displayed in computed tomography images correlated with hypoxia and angiogenesis in breast cancer.
Shan X, Wang D, Chen J, Xiao X, Jiang Y, Wang Y, Fan Y
Journal of computer assisted tomography 2013 Jan-Feb;37(1):22-8
Journal of computer assisted tomography 2013 Jan-Feb;37(1):22-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 11071-1-AP(CA9 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 11071-1-AP(CA9 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 11071-1-AP(CA9 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CA9 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CA9. This antibody recognizes human, mouse, rat antigen. The CA9 antibody has been validated for the following applications: ELISA, WB, IHC, IP, FC analysis.