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antibody from Novus Biologicals
Targeting: CA9
CAIX, MN
Western blot
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- Antibody Data
- Antigen structure
- References [192]
- Comments [0]
- Validations
- Western blot [5]
- Immunohistochemistry [8]
- Flow cytometry [1]
- Other assay [2]
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- Product number
- NB100-417 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-417, RRID:AB_10003398
- Product name
- Rabbit Polyclonal Carbonic Anhydrase IX/CA9 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1.0 mg/ml
- Storage
- Store at -20C. Avoid freeze-thaw cycles.
Submitted references Clinicopathological characterisation of renal cell carcinoma in young adults: a contemporary update and review of literature.
Sunitinib Treatment-elicited Distinct Tumor Microenvironment Dramatically Compensated the Reduction of Myeloid-derived Suppressor Cells.
Mucosal inflammation downregulates PHD1 expression promoting a barrier-protective HIF-1α response in ulcerative colitis patients.
Comprehensive Immunoprofiles of Renal Cell Carcinoma Subtypes.
Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer.
Clinicopathological Findings on 28 Cases with XP11.2 Renal Cell Carcinoma.
Diverse Resistance Mechanisms to the Third-Generation ALK Inhibitor Lorlatinib in ALK-Rearranged Lung Cancer.
Eradication of tumor growth by delivering novel photothermal selenium-coated tellurium nanoheterojunctions.
Optimization of Window Study Endpoints in Endometrial Cancer.
RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response.
Comparative Profiling of Metastatic 4T1- vs. Non-metastatic Py230-Based Mammary Tumors in an Intraductal Model for Triple-Negative Breast Cancer.
Volumetric Optoacoustic Imaging Unveils High-Resolution Patterns of Acute and Cyclic Hypoxia in a Murine Model of Breast Cancer.
S100A10 Is a Critical Mediator of GAS6/AXL-Induced Angiogenesis in Renal Cell Carcinoma.
Poor outcome in hypoxic endometrial carcinoma is related to vascular density.
Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma.
Quaking orchestrates a post-transcriptional regulatory network of endothelial cell cycle progression critical to angiogenesis and metastasis.
Clinical and morphologic review of 60 hereditary renal tumors from 30 hereditary renal cell carcinoma syndrome patients: lessons from a contemporary single institution series.
Quantitative Analysis of Carbonic Anhydrase IX Uncovers Hypoxia-Related Functional Differences in Classical Hodgkin Lymphoma Subtypes.
ONECUT2 is a driver of neuroendocrine prostate cancer.
Hypoxia-related carbonic anhydrase IX expression is associated with unfavourable response to first-line therapy in classical Hodgkin's lymphoma.
Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1α activation.
Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells.
18F-FDG Uptake in Well-Differentiated Neuroendocrine Tumors Correlates with Both Ki-67 and VHL Pathway Inactivation.
Utility of multiphasic multidetector computed tomography in discriminating between clear cell renal cell carcinomas with high and low carbonic anhydrase-IX expression.
Noninvasive Anatomical and Functional Imaging of Orthotopic Glioblastoma Development and Therapy using Multispectral Optoacoustic Tomography.
Surface-Enhanced Raman Scattering Nanoparticles for Multiplexed Imaging of Bladder Cancer Tissue Permeability and Molecular Phenotype.
Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis.
Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects.
BK virus-associated collecting duct carcinoma of the renal allograft in a kidney-pancreas allograft recipient.
Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model.
The proteoglycan-like domain of carbonic anhydrase IX mediates non-catalytic facilitation of lactate transport in cancer cells.
Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance.
Antiangiogenic effects of recombinant human endostatin in lung cancers.
Prognostic value of tissue necrosis, hypoxia-related markers and correlation with HPV status in head and neck cancer patients treated with bio- or chemo-radiotherapy.
Association of the Gross Appearance of Intratumoral Vascularity at MDCT With the Carbonic Anhydrase IX Score in Clear Cell Renal Cell Carcinoma.
Organoid Modeling of the Tumor Immune Microenvironment.
Rapid detection of metastatic lymph nodes of colorectal cancer with a gamma-glutamyl transpeptidase-activatable fluorescence probe.
Phenotype molding of stromal cells in the lung tumor microenvironment.
Localized hypoxia links ER stress to lung fibrosis through induction of C/EBP homologous protein.
Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer.
Heterogenic expression of stem cell markers in patient-derived glioblastoma spheroid cultures exposed to long-term hypoxia.
Programmed cell death ligands expression in phaeochromocytomas and paragangliomas: Relationship with the hypoxic response, immune evasion and malignant behavior.
Off-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production.
Targeting autophagic cancer stem-cells to reverse chemoresistance in human triple negative breast cancer.
Hypoxia activates placental growth factor expression in lymphatic endothelial cells.
A Pyloric Gland-Phenotype Ovarian Mucinous Tumor Resembling Lobular Endocervical Glandular Hyperplasia in a Patient with Peutz-Jeghers Syndrome.
Motor neurons control blood vessel patterning in the developing spinal cord.
Maintenance of antiangiogenic and antitumor effects by orally active low-dose capecitabine for long-term cancer therapy.
Cardiac glycosides suppress the maintenance of stemness and malignancy via inhibiting HIF-1α in human glioma stem cells.
Iron regulatory protein 2 in ovarian endometrial cysts.
Small cell lung cancer: model of circulating tumor cell tumorospheres in chemoresistance.
Genetic polymorphisms in key hypoxia-regulated downstream molecules and phenotypic correlation in prostate cancer.
Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation.
Strong antineoplastic effects of metformin in preclinical models of liver carcinogenesis.
Dissecting the Process of Activation of Cancer-promoting Zinc-requiring Ectoenzymes by Zinc Metalation Mediated by ZNT Transporters.
Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo.
BIRC3 is a biomarker of mesenchymal habitat of glioblastoma, and a mediator of survival adaptation in hypoxia-driven glioblastoma habitats.
Methods: Using Three-Dimensional Culture (Spheroids) as an In Vitro Model of Tumour Hypoxia.
A Sensitive IHC Method for Monitoring Autophagy-Specific Markers in Human Tumor Xenografts.
The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy.
Pancreatic Fibroblasts Stimulate the Motility of Pancreatic Cancer Cells through IGF1/IGF1R Signaling under Hypoxia.
Enhanced snoMEN Vectors Facilitate Establishment of GFP-HIF-1α Protein Replacement Human Cell Lines.
Transcriptome Sequencing (RNAseq) Enables Utilization of Formalin-Fixed, Paraffin-Embedded Biopsies with Clear Cell Renal Cell Carcinoma for Exploration of Disease Biology and Biomarker Development.
Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition.
MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival.
Revisiting decidual vasculopathy.
Targeting carbonic anhydrase IX improves the anti-cancer efficacy of mTOR inhibitors.
Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy.
Increased mitochondrial arginine metabolism supports bioenergetics in asthma.
Catalytic activity of human carbonic anhydrase isoform IX is displayed both extra- and intracellularly.
Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma.
CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells.
Development and confirmation of potential gene classifiers of human clear cell renal cell carcinoma using next-generation RNA sequencing.
Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer.
NQO1 inhibits proteasome-mediated degradation of HIF-1α.
Phase I study of evofosfamide, an investigational hypoxia-activated prodrug, in patients with advanced leukemia.
Lysyl oxidase is associated with the epithelial-mesenchymal transition of gastric cancer cells in hypoxia.
Simultaneous Targeting of Bladder Tumor Growth, Survival, and Epithelial-to-Mesenchymal Transition with a Novel Therapeutic Combination of Acetazolamide (AZ) and Sulforaphane (SFN).
Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function.
Characterization of tumor infiltrating lymphocytes in paired primary and metastatic renal cell carcinoma specimens.
Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models.
Indirect Tumor Cell Death After High-Dose Hypofractionated Irradiation: Implications for Stereotactic Body Radiation Therapy and Stereotactic Radiation Surgery.
Hypoxia-Inducible Factor-1α Is Associated With Sprouting Angiogenesis in the Murine Laser-Induced Choroidal Neovascularization Model.
The prognostic value of immunohistochemical markers for oral tongue squamous cell carcinoma.
Assessment of carbonic anhydrase IX expression and extracellular pH in B-cell lymphoma cell line models.
Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat.
Sunitinib but not VEGF blockade inhibits cancer stem cell endothelial differentiation.
Inhibition of vascular endothelial growth factor A and hypoxia-inducible factor 1α maximizes the effects of radiation in sarcoma mouse models through destruction of tumor vasculature.
Support for the hypoxia theory in the pathogenesis of infantile haemangioma.
Hypoxia-activated chemotherapeutic TH-302 enhances the effects of VEGF-A inhibition and radiation on sarcomas.
Effects of preset sequential administrations of sunitinib and everolimus on tumour differentiation in Caki-1 renal cell carcinoma.
Diffuse-type gastric cancer cells switch their driver pathways from FGFR2 signaling to SDF1/CXCR4 axis in hypoxic tumor microenvironments.
Fibrocyte-like cells mediate acquired resistance to anti-angiogenic therapy with bevacizumab.
Expression and diagnostic implications of carbonic anhydrase IX in several tumours with predominantly clear cell morphology.
Expression of carbonic anhydrase 9 is a novel prognostic marker in resectable hepatocellular carcinoma.
HIF-1α and CA-IX as predictors of locoregional control for determining the optimal treatment modality for early-stage laryngeal carcinoma.
Hypoxia-inducible TAp73 supports tumorigenesis by regulating the angiogenic transcriptome.
Tumor microenvironmental changes induced by the sulfamate carbonic anhydrase IX inhibitor S4 in a laryngeal tumor model.
The role of Hypoxia-inducible factor-1 α , glucose transporter-1, (GLUT-1) and carbon anhydrase IX in endometrial cancer patients.
PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia.
Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma.
Monitoring hypoxia and vasculature during bevacizumab treatment in a murine colorectal cancer model.
Reoxygenation from chronic hypoxia promotes metastatic processes in pancreatic cancer through the Hedgehog signaling.
An expression signature of the angiogenic response in gastrointestinal neuroendocrine tumours: correlation with tumour phenotype and survival outcomes.
Tbx1 regulates brain vascularization.
Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer.
The diagnostic accuracy of percutaneous renal needle core biopsy and its potential impact on the clinical management of renal cortical neoplasms.
Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy.
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway.
Activation of AMP-Activated Protein Kinase α and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells.
The use of porous scaffold as a tumor model.
Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: a new concept of dual targeting drugs.
Are morphological criteria sufficient for the identification of circulating tumor cells in renal cancer?
Downregulation of PHLPP expression contributes to hypoxia-induced resistance to chemotherapy in colon cancer cells.
Tubular von Hippel-Lindau knockout protects against rhabdomyolysis-induced AKI.
Wnt/β-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1α signaling.
Hypoxia enhances the interaction between pancreatic stellate cells and cancer cells via increased secretion of connective tissue growth factor.
β1 integrin targeting potentiates antiangiogenic therapy and inhibits the growth of bevacizumab-resistant glioblastoma.
Immunohistochemical analysis of cancer stem cell markers in invasive breast carcinoma and associated ductal carcinoma in situ: relationships with markers of tumor hypoxia and microvascularity.
Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells.
Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging.
Renal CD133(+)/CD73(+) progenitors produce erythropoietin under hypoxia and prolyl hydroxylase inhibition.
EG-VEGF controls placental growth and survival in normal and pathological pregnancies: case of fetal growth restriction (FGR).
Steep increase in myonuclear domain size during infancy.
Immunohistochemical markers of the hypoxic response can identify malignancy in phaeochromocytomas and paragangliomas and optimize the detection of tumours with VHL germline mutations.
Tumor dynamics in response to antiangiogenic therapy with oral metronomic topotecan and pazopanib in neuroblastoma xenografts.
Tumor dynamics in response to antiangiogenic therapy with oral metronomic topotecan and pazopanib in neuroblastoma xenografts.
Characterization of different osteosarcoma phenotypes by PET imaging in preclinical animal models.
Monitoring the effects of bevacizumab beyond progression in a murine colorectal cancer model: a functional imaging approach.
The expression of the hypoxia markers CA9 and CXCR4 is correlated with survival in patients with neuroendocrine tumours of the ileum.
Increased microglia/macrophage gene expression in a subset of adult and pediatric astrocytomas.
SIRT3 protects from hypoxia and staurosporine-mediated cell death by maintaining mitochondrial membrane potential and intracellular pH.
Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype.
Function of carbonic anhydrase IX in glioblastoma multiforme.
Increased activation of the hypoxia-inducible factor pathway in varicose veins.
Molecular profiling of pancreatic neuroendocrine tumors in sporadic and Von Hippel-Lindau patients.
Inclusive estimation of complex antigen presentation functions of monocyte-derived dendritic cells differentiated under normoxia and hypoxia conditions.
Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1.
Morphophenotypic characteristics of intralymphatic cancer and stromal cells susceptible to lymphogenic metastasis.
Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer.
Diflavin oxidoreductases activate the bioreductive prodrug PR-104A under hypoxia.
Lowered expression of galectin-2 is associated with lymph node metastasis in gastric cancer.
Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma.
Prognostic value of the chemokine receptor CXCR4 and epithelial-to-mesenchymal transition in patients with squamous cell carcinoma of the mobile tongue.
Predictive factors for response to treatment in patients with advanced renal cell carcinoma.
Prognostic factors in patients with advanced renal cell carcinoma.
Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.
Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers.
Characterization of the Tumor-Microenvironment in Patient-Derived Cervix Xenografts (OCICx).
The prognostic value of expression of HIF1α, EGFR and VEGF-A, in localized prostate cancer for intermediate- and high-risk patients treated with radiation therapy with or without androgen deprivation therapy.
Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104.
Hypoxia-inducible factor-1α mRNA: a new target for destabilization by tristetraprolin in endothelial cells.
Investigation on tumor hypoxia in resectable primary prostate cancer as demonstrated by 18F-FAZA PET/CT utilizing multimodality fusion techniques.
The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH.
Angiogenesis and host immune response contribute to the aggressive character of non-melanoma skin cancers in renal transplant recipients.
Role of immunohistochemistry in the evaluation of needle core biopsies in adult renal cortical tumors: an ex vivo study.
Role of hypoxia and EGF on expression, activity, localization and phosphorylation of carbonic anhydrase IX in MDA-MB-231 breast cancer cells.
IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina.
Expression of a hypoxia-associated protein, carbonic anhydrase-9, correlates with malignant phenotypes of gastric carcinoma.
Distinguishing clear cell renal cell carcinoma, retroperitoneal paraganglioma, and adrenal cortical lesions on limited biopsy material: utility of immunohistochemical markers.
A profile of prognostic and molecular factors in European and Māori breast cancer patients.
Interaction of hypoxia-inducible factor-1α and Notch signaling regulates medulloblastoma precursor proliferation and fate.
Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection.
Intratumoral hypoxic gradient drives stem cells distribution and MGMT expression in glioblastoma.
Hypoxia stimulates CXCR4 signalling in ileal carcinoids.
Carbonic anhydrase IX in renal cell carcinoma: implications for prognosis, diagnosis, and therapy.
Quantification of carbonic anhydrase IX expression in serum and tissue of renal cell carcinoma patients using enzyme-linked immunosorbent assay: prognostic and diagnostic potentials.
Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors.
Molecular markers associated with response to chemotherapy in gastro-entero-pancreatic neuroendocrine tumors.
Identification of a novel small molecule HIF-1alpha translation inhibitor.
gammaH2AX expression in tumors exposed to cisplatin and fractionated irradiation.
Tissue biomarkers in renal cell carcinoma: issues and solutions.
Plant morphogenesis: a role for mechanical signals.
Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma.
Expression and activity of carbonic anhydrase IX is associated with metabolic dysfunction in MDA-MB-231 breast cancer cells.
Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation.
Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization.
Carbonic anhydrase 9 is a predictive marker of survival benefit from lower dose of bevacizumab in patients with previously treated metastatic colorectal cancer.
Mediators of glioblastoma resistance and invasion during antivascular endothelial growth factor therapy.
Antibody-specific detection of CAIX in breast and prostate cancers.
Carbonic anhydrase IX expression in clear cell renal cell carcinoma: an immunohistochemical study comparing 2 antibodies.
Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection.
Brachytherapy for oral tongue cancer: an analysis of treatment results with various biological markers.
Tumor necrosis is associated with increased alphavbeta3 integrin expression and poor prognosis in nodular cutaneous melanomas.
Carbonic anhydrase IX expression in clear cell renal cell carcinomas negatively correlates with the proportion of the granular cell component.
An orthotopic skull base model of malignant meningioma.
Hypoxia can be detected in irradiated normal human tissue: a study using the hypoxic marker pimonidazole hydrochloride.
Is the downregulation of EphB2 receptor expression during colorectal tumorigenesis due to hypoxia?
Expression of the hypoxia marker carbonic anhydrase 9 is associated with anaplastic phenotypes in meningiomas.
Angiogenesis and hypoxia in lymph node metastases is predicted by the angiogenesis and hypoxia in the primary tumour in patients with breast cancer.
Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer.
[Recent evaluation of a Candida hemagglutination test].
Abdulfatah E, Kennedy JM, Hafez K, Davenport MS, Xiao H, Weizer AZ, Palapattu GS, Morgan TM, Mannan R, Wang XM, Dhanasekaran SM, Kaffenberger SD, Spratt DE, Kunju L, Wu A, Lew M, Udager AM, Chinnaiyan AM, Mehra R
Histopathology 2020 May;76(6):875-887
Histopathology 2020 May;76(6):875-887
Sunitinib Treatment-elicited Distinct Tumor Microenvironment Dramatically Compensated the Reduction of Myeloid-derived Suppressor Cells.
Fu SY, Wang CC, Chen FH, Yu CF, Hong JH, Chiang CS
In vivo (Athens, Greece) 2020 May-Jun;34(3):1141-1152
In vivo (Athens, Greece) 2020 May-Jun;34(3):1141-1152
Mucosal inflammation downregulates PHD1 expression promoting a barrier-protective HIF-1α response in ulcerative colitis patients.
Brown E, Rowan C, Strowitzki MJ, Fagundes RR, Faber KN, Güntsch A, Halligan DN, Kugler J, Jones F, Lee CT, Doherty G, Taylor CT
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):3732-3742
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):3732-3742
Comprehensive Immunoprofiles of Renal Cell Carcinoma Subtypes.
Kim M, Joo JW, Lee SJ, Cho YA, Park CK, Cho NH
Cancers 2020 Mar 5;12(3)
Cancers 2020 Mar 5;12(3)
Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer.
Becker LM, O'Connell JT, Vo AP, Cain MP, Tampe D, Bizarro L, Sugimoto H, McGow AK, Asara JM, Lovisa S, McAndrews KM, Zielinski R, Lorenzi PL, Zeisberg M, Raza S, LeBleu VS, Kalluri R
Cell reports 2020 Jun 2;31(9):107701
Cell reports 2020 Jun 2;31(9):107701
Clinicopathological Findings on 28 Cases with XP11.2 Renal Cell Carcinoma.
Kuthi L, Somorácz Á, Micsik T, Jenei A, Hajdu A, Sejben I, Imre D, Pósfai B, Kóczián K, Semjén D, Bajory Z, Kulka J, Iványi B
Pathology oncology research : POR 2020 Jan 18;
Pathology oncology research : POR 2020 Jan 18;
Diverse Resistance Mechanisms to the Third-Generation ALK Inhibitor Lorlatinib in ALK-Rearranged Lung Cancer.
Recondo G, Mezquita L, Facchinetti F, Planchard D, Gazzah A, Bigot L, Rizvi AZ, Frias RL, Thiery JP, Scoazec JY, Sourisseau T, Howarth K, Deas O, Samofalova D, Galissant J, Tesson P, Braye F, Naltet C, Lavaud P, Mahjoubi L, Abou Lovergne A, Vassal G, Bahleda R, Hollebecque A, Nicotra C, Ngo-Camus M, Michiels S, Lacroix L, Richon C, Auger N, De Baere T, Tselikas L, Solary E, Angevin E, Eggermont AM, Andre F, Massard C, Olaussen KA, Soria JC, Besse B, Friboulet L
Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Jan 1;26(1):242-255
Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Jan 1;26(1):242-255
Eradication of tumor growth by delivering novel photothermal selenium-coated tellurium nanoheterojunctions.
Chen S, Xing C, Huang D, Zhou C, Ding B, Guo Z, Peng Z, Wang D, Zhu X, Liu S, Cai Z, Wu J, Zhao J, Wu Z, Zhang Y, Wei C, Yan Q, Wang H, Fan D, Liu L, Zhang H, Cao Y
Science advances 2020 Apr;6(15):eaay6825
Science advances 2020 Apr;6(15):eaay6825
Optimization of Window Study Endpoints in Endometrial Cancer.
Kitson SJ, Maskell Z, Sivalingam VN, Shaw J, Crosbie EJ
Frontiers in oncology 2019;9:428
Frontiers in oncology 2019;9:428
RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response.
Frost J, Ciulli A, Rocha S
Wellcome open research 2019;4:17
Wellcome open research 2019;4:17
Comparative Profiling of Metastatic 4T1- vs. Non-metastatic Py230-Based Mammary Tumors in an Intraductal Model for Triple-Negative Breast Cancer.
Steenbrugge J, Vander Elst N, Demeyere K, De Wever O, Sanders NN, Van Den Broeck W, Dirix L, Van Laere S, Meyer E
Frontiers in immunology 2019;10:2928
Frontiers in immunology 2019;10:2928
Volumetric Optoacoustic Imaging Unveils High-Resolution Patterns of Acute and Cyclic Hypoxia in a Murine Model of Breast Cancer.
Ron A, Deán-Ben XL, Gottschalk S, Razansky D
Cancer research 2019 Sep 15;79(18):4767-4775
Cancer research 2019 Sep 15;79(18):4767-4775
S100A10 Is a Critical Mediator of GAS6/AXL-Induced Angiogenesis in Renal Cell Carcinoma.
Xiao Y, Zhao H, Tian L, Nolley R, Diep AN, Ernst A, Fuh KC, Miao YR, von Eyben R, Leppert JT, Brooks JD, Peehl DM, Giaccia AJ, Rankin EB
Cancer research 2019 Nov 15;79(22):5758-5768
Cancer research 2019 Nov 15;79(22):5758-5768
Poor outcome in hypoxic endometrial carcinoma is related to vascular density.
Reijnen C, van Weelden WJ, Arts MSJP, Peters JP, Rijken PF, van de Vijver K, Santacana M, Bronsert P, Bulten J, Hirschfeld M, Colas E, Gil-Moreno A, Reques A, Mancebo G, Krakstad C, Trovik J, Haldorsen IS, Huvila J, Koskas M, Weinberger V, Minar L, Jandakova E, Snijders MPLM, van den Berg-van Erp S, Küsters-Vandevelde HVN, Matias-Guiu X, Amant F, ENITEC-consortium, Massuger LFAG, Bussink J, Pijnenborg JMA
British journal of cancer 2019 May;120(11):1037-1044
British journal of cancer 2019 May;120(11):1037-1044
Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma.
Najjar YG, Menk AV, Sander C, Rao U, Karunamurthy A, Bhatia R, Zhai S, Kirkwood JM, Delgoffe GM
JCI insight 2019 Mar 7;4(5)
JCI insight 2019 Mar 7;4(5)
Quaking orchestrates a post-transcriptional regulatory network of endothelial cell cycle progression critical to angiogenesis and metastasis.
Azam SH, Porrello A, Harrison EB, Leslie PL, Liu X, Waugh TA, Belanger A, Mangala LS, Lopez-Berestein G, Wilson HL, McCann JV, Kim WY, Sood AK, Liu J, Dudley AC, Pecot CV
Oncogene 2019 Jun;38(26):5191-5210
Oncogene 2019 Jun;38(26):5191-5210
Clinical and morphologic review of 60 hereditary renal tumors from 30 hereditary renal cell carcinoma syndrome patients: lessons from a contemporary single institution series.
Kennedy JM, Wang X, Plouffe KR, Dhanasekaran SM, Hafez K, Palapattu GS, Else T, Weizer AZ, Morgan TM, Spratt DE, Davenport MS, Chinnaiyan AM, Udager AM, Mehra R
Medical oncology (Northwood, London, England) 2019 Jul 22;36(9):74
Medical oncology (Northwood, London, England) 2019 Jul 22;36(9):74
Quantitative Analysis of Carbonic Anhydrase IX Uncovers Hypoxia-Related Functional Differences in Classical Hodgkin Lymphoma Subtypes.
Matolay O, Beke L, Gyurkovics A, Francz M, Varjasi G, Rejtő L, Illés Á, Bedekovics J, Méhes G
International journal of molecular sciences 2019 Jul 15;20(14)
International journal of molecular sciences 2019 Jul 15;20(14)
ONECUT2 is a driver of neuroendocrine prostate cancer.
Guo H, Ci X, Ahmed M, Hua JT, Soares F, Lin D, Puca L, Vosoughi A, Xue H, Li E, Su P, Chen S, Nguyen T, Liang Y, Zhang Y, Xu X, Xu J, Sheahan AV, Ba-Alawi W, Zhang S, Mahamud O, Vellanki RN, Gleave M, Bristow RG, Haibe-Kains B, Poirier JT, Rudin CM, Tsao MS, Wouters BG, Fazli L, Feng FY, Ellis L, van der Kwast T, Berlin A, Koritzinsky M, Boutros PC, Zoubeidi A, Beltran H, Wang Y, He HH
Nature communications 2019 Jan 17;10(1):278
Nature communications 2019 Jan 17;10(1):278
Hypoxia-related carbonic anhydrase IX expression is associated with unfavourable response to first-line therapy in classical Hodgkin's lymphoma.
Méhes G, Matolay O, Beke L, Czenke M, Jóna Á, Miltényi Z, Illés Á, Bedekovics J
Histopathology 2019 Apr;74(5):699-708
Histopathology 2019 Apr;74(5):699-708
Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1α activation.
Ferecatu I, Canal F, Fabbri L, Mazure NM, Bouton C, Golinelli-Cohen MP
PloS one 2018;13(3):e0194782
PloS one 2018;13(3):e0194782
Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells.
Dreyer-Andersen N, Almeida AS, Jensen P, Kamand M, Okarmus J, Rosenberg T, Friis SD, Martínez Serrano A, Blaabjerg M, Kristensen BW, Skrydstrup T, Gramsbergen JB, Vieira HLA, Meyer M
PloS one 2018;13(1):e0191207
PloS one 2018;13(1):e0191207
18F-FDG Uptake in Well-Differentiated Neuroendocrine Tumors Correlates with Both Ki-67 and VHL Pathway Inactivation.
Bucau M, Laurent-Bellue A, Poté N, Hentic O, Cros J, Mikail N, Rebours V, Ruszniewski P, Lebtahi R, Couvelard A
Neuroendocrinology 2018;106(3):274-282
Neuroendocrinology 2018;106(3):274-282
Utility of multiphasic multidetector computed tomography in discriminating between clear cell renal cell carcinomas with high and low carbonic anhydrase-IX expression.
Young JR, Coy H, Kim HJ, Douek M, Sisk A, Belldegrun A, Pantuck AJ, Raman SS
Abdominal radiology (New York) 2018 Oct;43(10):2734-2742
Abdominal radiology (New York) 2018 Oct;43(10):2734-2742
Noninvasive Anatomical and Functional Imaging of Orthotopic Glioblastoma Development and Therapy using Multispectral Optoacoustic Tomography.
Balasundaram G, Ding L, Li X, Attia ABE, Dean-Ben XL, Ho CJH, Chandrasekharan P, Tay HC, Lim HQ, Ong CB, Mason RP, Razansky D, Olivo M
Translational oncology 2018 Oct;11(5):1251-1258
Translational oncology 2018 Oct;11(5):1251-1258
Surface-Enhanced Raman Scattering Nanoparticles for Multiplexed Imaging of Bladder Cancer Tissue Permeability and Molecular Phenotype.
Davis RM, Kiss B, Trivedi DR, Metzner TJ, Liao JC, Gambhir SS
ACS nano 2018 Oct 23;12(10):9669-9679
ACS nano 2018 Oct 23;12(10):9669-9679
Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis.
Greenhough A, Bagley C, Heesom KJ, Gurevich DB, Gay D, Bond M, Collard TJ, Paraskeva C, Martin P, Sansom OJ, Malik K, Williams AC
EMBO molecular medicine 2018 Nov;10(11)
EMBO molecular medicine 2018 Nov;10(11)
Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects.
Corbet C, Bastien E, Draoui N, Doix B, Mignion L, Jordan BF, Marchand A, Vanherck JC, Chaltin P, Schakman O, Becker HM, Riant O, Feron O
Nature communications 2018 Mar 23;9(1):1208
Nature communications 2018 Mar 23;9(1):1208
BK virus-associated collecting duct carcinoma of the renal allograft in a kidney-pancreas allograft recipient.
Dao M, Pécriaux A, Bessede T, Dürrbach A, Mussini C, Guettier C, Ferlicot S
Oncotarget 2018 Mar 13;9(19):15157-15163
Oncotarget 2018 Mar 13;9(19):15157-15163
Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model.
Toonen LJA, Overzier M, Evers MM, Leon LG, van der Zeeuw SAJ, Mei H, Kielbasa SM, Goeman JJ, Hettne KM, Magnusson OT, Poirel M, Seyer A, 't Hoen PAC, van Roon-Mom WMC
Molecular neurodegeneration 2018 Jun 22;13(1):31
Molecular neurodegeneration 2018 Jun 22;13(1):31
The proteoglycan-like domain of carbonic anhydrase IX mediates non-catalytic facilitation of lactate transport in cancer cells.
Ames S, Pastorekova S, Becker HM
Oncotarget 2018 Jun 15;9(46):27940-27957
Oncotarget 2018 Jun 15;9(46):27940-27957
Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance.
Iwamoto H, Abe M, Yang Y, Cui D, Seki T, Nakamura M, Hosaka K, Lim S, Wu J, He X, Sun X, Lu Y, Zhou Q, Shi W, Torimura T, Nie G, Li Q, Cao Y
Cell metabolism 2018 Jul 3;28(1):104-117.e5
Cell metabolism 2018 Jul 3;28(1):104-117.e5
Antiangiogenic effects of recombinant human endostatin in lung cancers.
He L, Zhao C, Li Y, Du G, Liu K, Cui D, Tang L, Wu X, Wen S, Chen H
Molecular medicine reports 2018 Jan;17(1):79-86
Molecular medicine reports 2018 Jan;17(1):79-86
Prognostic value of tissue necrosis, hypoxia-related markers and correlation with HPV status in head and neck cancer patients treated with bio- or chemo-radiotherapy.
Ou D, Garberis I, Adam J, Blanchard P, Nguyen F, Levy A, Casiraghi O, Gorphe P, Breuskin I, Janot F, Temam S, Scoazec JY, Deutsch E, Tao Y
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2018 Jan;126(1):116-124
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2018 Jan;126(1):116-124
Association of the Gross Appearance of Intratumoral Vascularity at MDCT With the Carbonic Anhydrase IX Score in Clear Cell Renal Cell Carcinoma.
Young JR, Coy H, Kim HJ, Douek M, Sisk A, Pantuck AJ, Raman SS
AJR. American journal of roentgenology 2018 Dec;211(6):1254-1258
AJR. American journal of roentgenology 2018 Dec;211(6):1254-1258
Organoid Modeling of the Tumor Immune Microenvironment.
Neal JT, Li X, Zhu J, Giangarra V, Grzeskowiak CL, Ju J, Liu IH, Chiou SH, Salahudeen AA, Smith AR, Deutsch BC, Liao L, Zemek AJ, Zhao F, Karlsson K, Schultz LM, Metzner TJ, Nadauld LD, Tseng YY, Alkhairy S, Oh C, Keskula P, Mendoza-Villanueva D, De La Vega FM, Kunz PL, Liao JC, Leppert JT, Sunwoo JB, Sabatti C, Boehm JS, Hahn WC, Zheng GXY, Davis MM, Kuo CJ
Cell 2018 Dec 13;175(7):1972-1988.e16
Cell 2018 Dec 13;175(7):1972-1988.e16
Rapid detection of metastatic lymph nodes of colorectal cancer with a gamma-glutamyl transpeptidase-activatable fluorescence probe.
Kubo H, Hanaoka K, Kuriki Y, Komatsu T, Ueno T, Kojima R, Kamiya M, Murayama Y, Otsuji E, Urano Y
Scientific reports 2018 Dec 12;8(1):17781
Scientific reports 2018 Dec 12;8(1):17781
Phenotype molding of stromal cells in the lung tumor microenvironment.
Lambrechts D, Wauters E, Boeckx B, Aibar S, Nittner D, Burton O, Bassez A, Decaluwé H, Pircher A, Van den Eynde K, Weynand B, Verbeken E, De Leyn P, Liston A, Vansteenkiste J, Carmeliet P, Aerts S, Thienpont B
Nature medicine 2018 Aug;24(8):1277-1289
Nature medicine 2018 Aug;24(8):1277-1289
Localized hypoxia links ER stress to lung fibrosis through induction of C/EBP homologous protein.
Burman A, Kropski JA, Calvi CL, Serezani AP, Pascoalino BD, Han W, Sherrill T, Gleaves L, Lawson WE, Young LR, Blackwell TS, Tanjore H
JCI insight 2018 Aug 23;3(16)
JCI insight 2018 Aug 23;3(16)
Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer.
Steenbrugge J, Breyne K, Demeyere K, De Wever O, Sanders NN, Van Den Broeck W, Colpaert C, Vermeulen P, Van Laere S, Meyer E
Journal of experimental & clinical cancer research : CR 2018 Aug 15;37(1):191
Journal of experimental & clinical cancer research : CR 2018 Aug 15;37(1):191
Heterogenic expression of stem cell markers in patient-derived glioblastoma spheroid cultures exposed to long-term hypoxia.
Rosenberg T, Aaberg-Jessen C, Petterson SA, Kristensen BW
CNS oncology 2018 Apr;7(2):CNS15
CNS oncology 2018 Apr;7(2):CNS15
Programmed cell death ligands expression in phaeochromocytomas and paragangliomas: Relationship with the hypoxic response, immune evasion and malignant behavior.
Pinato DJ, Black JR, Trousil S, Dina RE, Trivedi P, Mauri FA, Sharma R
Oncoimmunology 2017;6(11):e1358332
Oncoimmunology 2017;6(11):e1358332
Off-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production.
Nakamura M, Zhang Y, Yang Y, Sonmez C, Zheng W, Huang G, Seki T, Iwamoto H, Ding B, Yin L, Foukakis T, Hatschek T, Li X, Hosaka K, Li J, Yu G, Wang X, Liu Y, Cao Y
Proceedings of the National Academy of Sciences of the United States of America 2017 Nov 7;114(45):E9635-E9644
Proceedings of the National Academy of Sciences of the United States of America 2017 Nov 7;114(45):E9635-E9644
Targeting autophagic cancer stem-cells to reverse chemoresistance in human triple negative breast cancer.
Bousquet G, El Bouchtaoui M, Sophie T, Leboeuf C, de Bazelaire C, Ratajczak P, Giacchetti S, de Roquancourt A, Bertheau P, Verneuil L, Feugeas JP, Espié M, Janin A
Oncotarget 2017 May 23;8(21):35205-35221
Oncotarget 2017 May 23;8(21):35205-35221
Hypoxia activates placental growth factor expression in lymphatic endothelial cells.
Tudisco L, Orlandi A, Tarallo V, De Falco S
Oncotarget 2017 May 16;8(20):32873-32883
Oncotarget 2017 May 16;8(20):32873-32883
A Pyloric Gland-Phenotype Ovarian Mucinous Tumor Resembling Lobular Endocervical Glandular Hyperplasia in a Patient with Peutz-Jeghers Syndrome.
Kim EN, Kim GH, Kim J, Park IA, Shin JH, Chai Y, Kim KR
Journal of pathology and translational medicine 2017 Mar;51(2):159-164
Journal of pathology and translational medicine 2017 Mar;51(2):159-164
Motor neurons control blood vessel patterning in the developing spinal cord.
Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti HH, Ermakova O, Rempel E, Stoeckli ET, Ruiz de Almodóvar C
Nature communications 2017 Mar 6;8:14583
Nature communications 2017 Mar 6;8:14583
Maintenance of antiangiogenic and antitumor effects by orally active low-dose capecitabine for long-term cancer therapy.
Zhang Y, Sun M, Huang G, Yin L, Lai Q, Yang Y, Xing X, Yu G, Sun Y, Wang X, Nie G, Liu Y, Cao Y
Proceedings of the National Academy of Sciences of the United States of America 2017 Jun 27;114(26):E5226-E5235
Proceedings of the National Academy of Sciences of the United States of America 2017 Jun 27;114(26):E5226-E5235
Cardiac glycosides suppress the maintenance of stemness and malignancy via inhibiting HIF-1α in human glioma stem cells.
Lee DH, Cheul Oh S, Giles AJ, Jung J, Gilbert MR, Park DM
Oncotarget 2017 Jun 20;8(25):40233-40245
Oncotarget 2017 Jun 20;8(25):40233-40245
Iron regulatory protein 2 in ovarian endometrial cysts.
Takenaka M, Suzuki N, Mori M, Hirayama T, Nagasawa H, Morishige KI
Biochemical and biophysical research communications 2017 Jun 10;487(4):789-794
Biochemical and biophysical research communications 2017 Jun 10;487(4):789-794
Small cell lung cancer: model of circulating tumor cell tumorospheres in chemoresistance.
Klameth L, Rath B, Hochmaier M, Moser D, Redl M, Mungenast F, Gelles K, Ulsperger E, Zeillinger R, Hamilton G
Scientific reports 2017 Jul 13;7(1):5337
Scientific reports 2017 Jul 13;7(1):5337
Genetic polymorphisms in key hypoxia-regulated downstream molecules and phenotypic correlation in prostate cancer.
Fraga A, Ribeiro R, Coelho A, Vizcaíno JR, Coutinho H, Lopes JM, Príncipe P, Lobato C, Lopes C, Medeiros R
BMC urology 2017 Jan 31;17(1):12
BMC urology 2017 Jan 31;17(1):12
Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation.
Bulusu V, Tumanov S, Michalopoulou E, van den Broek NJ, MacKay G, Nixon C, Dhayade S, Schug ZT, Vande Voorde J, Blyth K, Gottlieb E, Vazquez A, Kamphorst JJ
Cell reports 2017 Jan 17;18(3):647-658
Cell reports 2017 Jan 17;18(3):647-658
Strong antineoplastic effects of metformin in preclinical models of liver carcinogenesis.
Cauchy F, Mebarki M, Leporq B, Laouirem S, Albuquerque M, Lambert S, Bourgoin P, Soubrane O, Van Beers BE, Faivre S, Bedossa P, Paradis V
Clinical science (London, England : 1979) 2017 Jan 1;131(1):27-36
Clinical science (London, England : 1979) 2017 Jan 1;131(1):27-36
Dissecting the Process of Activation of Cancer-promoting Zinc-requiring Ectoenzymes by Zinc Metalation Mediated by ZNT Transporters.
Tsuji T, Kurokawa Y, Chiche J, Pouysségur J, Sato H, Fukuzawa H, Nagao M, Kambe T
The Journal of biological chemistry 2017 Feb 10;292(6):2159-2173
The Journal of biological chemistry 2017 Feb 10;292(6):2159-2173
Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo.
Boyd NH, Walker K, Fried J, Hackney JR, McDonald PC, Benavides GA, Spina R, Audia A, Scott SE, Landis CJ, Tran AN, Bevensee MO, Griguer C, Nozell S, Gillespie GY, Nabors B, Bhat KP, Bar EE, Darley-Usmar V, Xu B, Gordon E, Cooper SJ, Dedhar S, Hjelmeland AB
JCI insight 2017 Dec 21;2(24)
JCI insight 2017 Dec 21;2(24)
BIRC3 is a biomarker of mesenchymal habitat of glioblastoma, and a mediator of survival adaptation in hypoxia-driven glioblastoma habitats.
Wang D, Berglund AE, Kenchappa RS, MacAulay RJ, Mulé JJ, Etame AB
Scientific reports 2017 Aug 24;7(1):9350
Scientific reports 2017 Aug 24;7(1):9350
Methods: Using Three-Dimensional Culture (Spheroids) as an In Vitro Model of Tumour Hypoxia.
Leek R, Grimes DR, Harris AL, McIntyre A
Advances in experimental medicine and biology 2016;899:167-96
Advances in experimental medicine and biology 2016;899:167-96
A Sensitive IHC Method for Monitoring Autophagy-Specific Markers in Human Tumor Xenografts.
He H, Yang Y, Xiang Z, Yu L, Chouitar J, Yu J, D'Amore NR, Li P, Li Z, Bowman D, Theisen M, Brownell JE, Tirrell S
Journal of biomarkers 2016;2016:1274603
Journal of biomarkers 2016;2016:1274603
The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy.
van Kuijk SJ, Gieling RG, Niemans R, Lieuwes NG, Biemans R, Telfer BA, Haenen GR, Yaromina A, Lambin P, Dubois LJ, Williams KJ
PloS one 2016;11(8):e0161040
PloS one 2016;11(8):e0161040
Pancreatic Fibroblasts Stimulate the Motility of Pancreatic Cancer Cells through IGF1/IGF1R Signaling under Hypoxia.
Hirakawa T, Yashiro M, Doi Y, Kinoshita H, Morisaki T, Fukuoka T, Hasegawa T, Kimura K, Amano R, Hirakawa K
PloS one 2016;11(8):e0159912
PloS one 2016;11(8):e0159912
Enhanced snoMEN Vectors Facilitate Establishment of GFP-HIF-1α Protein Replacement Human Cell Lines.
Ono M, Yamada K, Bensaddek D, Afzal V, Biddlestone J, Ortmann B, Mudie S, Boivin V, Scott MS, Rocha S, Lamond AI
PloS one 2016;11(4):e0154759
PloS one 2016;11(4):e0154759
Transcriptome Sequencing (RNAseq) Enables Utilization of Formalin-Fixed, Paraffin-Embedded Biopsies with Clear Cell Renal Cell Carcinoma for Exploration of Disease Biology and Biomarker Development.
Eikrem O, Beisland C, Hjelle K, Flatberg A, Scherer A, Landolt L, Skogstrand T, Leh S, Beisvag V, Marti HP
PloS one 2016;11(2):e0149743
PloS one 2016;11(2):e0149743
Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition.
Frost J, Galdeano C, Soares P, Gadd MS, Grzes KM, Ellis L, Epemolu O, Shimamura S, Bantscheff M, Grandi P, Read KD, Cantrell DA, Rocha S, Ciulli A
Nature communications 2016 Nov 4;7:13312
Nature communications 2016 Nov 4;7:13312
MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival.
Radoul M, Chaumeil MM, Eriksson P, Wang AS, Phillips JJ, Ronen SM
Molecular cancer therapeutics 2016 May;15(5):1113-22
Molecular cancer therapeutics 2016 May;15(5):1113-22
Revisiting decidual vasculopathy.
Hecht JL, Zsengeller ZK, Spiel M, Karumanchi SA, Rosen S
Placenta 2016 Jun;42:37-43
Placenta 2016 Jun;42:37-43
Targeting carbonic anhydrase IX improves the anti-cancer efficacy of mTOR inhibitors.
Faes S, Planche A, Uldry E, Santoro T, Pythoud C, Stehle JC, Horlbeck J, Letovanec I, Riggi N, Datta D, Demartines N, Dormond O
Oncotarget 2016 Jun 14;7(24):36666-36680
Oncotarget 2016 Jun 14;7(24):36666-36680
Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy.
Yoon C, Chang KK, Lee JH, Tap WD, Hart CP, Simon MC, Yoon SS
Oncotarget 2016 Jul 12;7(28):42844-42858
Oncotarget 2016 Jul 12;7(28):42844-42858
Increased mitochondrial arginine metabolism supports bioenergetics in asthma.
Xu W, Ghosh S, Comhair SA, Asosingh K, Janocha AJ, Mavrakis DA, Bennett CD, Gruca LL, Graham BB, Queisser KA, Kao CC, Wedes SH, Petrich JM, Tuder RM, Kalhan SC, Erzurum SC
The Journal of clinical investigation 2016 Jul 1;126(7):2465-81
The Journal of clinical investigation 2016 Jul 1;126(7):2465-81
Catalytic activity of human carbonic anhydrase isoform IX is displayed both extra- and intracellularly.
Klier M, Jamali S, Ames S, Schneider HP, Becker HM, Deitmer JW
The FEBS journal 2016 Jan;283(1):191-200
The FEBS journal 2016 Jan;283(1):191-200
Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma.
Scholz A, Harter PN, Cremer S, Yalcin BH, Gurnik S, Yamaji M, Di Tacchio M, Sommer K, Baumgarten P, Bähr O, Steinbach JP, Trojan J, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Braun C, Schittenhelm J, Frueh JT, Ullrich E, Mittelbronn M, Plate KH, Reiss Y
EMBO molecular medicine 2016 Jan 1;8(1):39-57
EMBO molecular medicine 2016 Jan 1;8(1):39-57
CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells.
Ortmann B, Bensaddek D, Carvalhal S, Moser SC, Mudie S, Griffis ER, Swedlow JR, Lamond AI, Rocha S
Journal of cell science 2016 Jan 1;129(1):191-205
Journal of cell science 2016 Jan 1;129(1):191-205
Development and confirmation of potential gene classifiers of human clear cell renal cell carcinoma using next-generation RNA sequencing.
Eikrem OS, Strauss P, Beisland C, Scherer A, Landolt L, Flatberg A, Leh S, Beisvag V, Skogstrand T, Hjelle K, Shresta A, Marti HP
Scandinavian journal of urology 2016 Dec;50(6):452-462
Scandinavian journal of urology 2016 Dec;50(6):452-462
Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer.
Huang Y, Lichtenberger LM, Taylor M, Bottsford-Miller JN, Haemmerle M, Wagner MJ, Lyons Y, Pradeep S, Hu W, Previs RA, Hansen JM, Fang D, Dorniak PL, Filant J, Dial EJ, Shen F, Hatakeyama H, Sood AK
Molecular cancer therapeutics 2016 Dec;15(12):2894-2904
Molecular cancer therapeutics 2016 Dec;15(12):2894-2904
NQO1 inhibits proteasome-mediated degradation of HIF-1α.
Oh ET, Kim JW, Kim JM, Kim SJ, Lee JS, Hong SS, Goodwin J, Ruthenborg RJ, Jung MG, Lee HJ, Lee CH, Park ES, Kim C, Park HJ
Nature communications 2016 Dec 14;7:13593
Nature communications 2016 Dec 14;7:13593
Phase I study of evofosfamide, an investigational hypoxia-activated prodrug, in patients with advanced leukemia.
Badar T, Handisides DR, Benito JM, Richie MA, Borthakur G, Jabbour E, Harutyunyan K, Konoplev S, Faderl S, Kroll S, Andreeff M, Pearce T, Kantarjian HM, Cortes JE, Thomas DA, Konopleva M
American journal of hematology 2016 Aug;91(8):800-5
American journal of hematology 2016 Aug;91(8):800-5
Lysyl oxidase is associated with the epithelial-mesenchymal transition of gastric cancer cells in hypoxia.
Kasashima H, Yashiro M, Kinoshita H, Fukuoka T, Morisaki T, Masuda G, Sakurai K, Kubo N, Ohira M, Hirakawa K
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2016 Apr;19(2):431-442
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2016 Apr;19(2):431-442
Simultaneous Targeting of Bladder Tumor Growth, Survival, and Epithelial-to-Mesenchymal Transition with a Novel Therapeutic Combination of Acetazolamide (AZ) and Sulforaphane (SFN).
Islam SS, Mokhtari RB, Akbari P, Hatina J, Yeger H, Farhat WA
Targeted oncology 2016 Apr;11(2):209-27
Targeted oncology 2016 Apr;11(2):209-27
Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function.
Jamali S, Klier M, Ames S, Barros LF, McKenna R, Deitmer JW, Becker HM
Scientific reports 2015 Sep 4;5:13605
Scientific reports 2015 Sep 4;5:13605
Characterization of tumor infiltrating lymphocytes in paired primary and metastatic renal cell carcinoma specimens.
Baine MK, Turcu G, Zito CR, Adeniran AJ, Camp RL, Chen L, Kluger HM, Jilaveanu LB
Oncotarget 2015 Sep 22;6(28):24990-5002
Oncotarget 2015 Sep 22;6(28):24990-5002
Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models.
Ward C, Meehan J, Mullen P, Supuran C, Dixon JM, Thomas JS, Winum JY, Lambin P, Dubois L, Pavathaneni NK, Jarman EJ, Renshaw L, Um IH, Kay C, Harrison DJ, Kunkler IH, Langdon SP
Oncotarget 2015 Sep 22;6(28):24856-70
Oncotarget 2015 Sep 22;6(28):24856-70
Indirect Tumor Cell Death After High-Dose Hypofractionated Irradiation: Implications for Stereotactic Body Radiation Therapy and Stereotactic Radiation Surgery.
Song CW, Lee YJ, Griffin RJ, Park I, Koonce NA, Hui S, Kim MS, Dusenbery KE, Sperduto PW, Cho LC
International journal of radiation oncology, biology, physics 2015 Sep 1;93(1):166-72
International journal of radiation oncology, biology, physics 2015 Sep 1;93(1):166-72
Hypoxia-Inducible Factor-1α Is Associated With Sprouting Angiogenesis in the Murine Laser-Induced Choroidal Neovascularization Model.
André H, Tunik S, Aronsson M, Kvanta A
Investigative ophthalmology & visual science 2015 Oct;56(11):6591-604
Investigative ophthalmology & visual science 2015 Oct;56(11):6591-604
The prognostic value of immunohistochemical markers for oral tongue squamous cell carcinoma.
Hwa JS, Kwon OJ, Park JJ, Woo SH, Kim JP, Ko GH, Seo JH, Kim RB
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2015 Oct;272(10):2953-9
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2015 Oct;272(10):2953-9
Assessment of carbonic anhydrase IX expression and extracellular pH in B-cell lymphoma cell line models.
Chen LQ, Howison CM, Spier C, Stopeck AT, Malm SW, Pagel MD, Baker AF
Leukemia & lymphoma 2015 May;56(5):1432-9
Leukemia & lymphoma 2015 May;56(5):1432-9
Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat.
Cotroneo E, Ashek A, Wang L, Wharton J, Dubois O, Bozorgi S, Busbridge M, Alavian KN, Wilkins MR, Zhao L
Circulation research 2015 May 8;116(10):1680-90
Circulation research 2015 May 8;116(10):1680-90
Sunitinib but not VEGF blockade inhibits cancer stem cell endothelial differentiation.
Brossa A, Grange C, Mancuso L, Annaratone L, Satolli MA, Mazzone M, Camussi G, Bussolati B
Oncotarget 2015 May 10;6(13):11295-309
Oncotarget 2015 May 10;6(13):11295-309
Inhibition of vascular endothelial growth factor A and hypoxia-inducible factor 1α maximizes the effects of radiation in sarcoma mouse models through destruction of tumor vasculature.
Lee HJ, Yoon C, Park DJ, Kim YJ, Schmidt B, Lee YJ, Tap WD, Eisinger-Mathason TS, Choy E, Kirsch DG, Simon MC, Yoon SS
International journal of radiation oncology, biology, physics 2015 Mar 1;91(3):621-30
International journal of radiation oncology, biology, physics 2015 Mar 1;91(3):621-30
Support for the hypoxia theory in the pathogenesis of infantile haemangioma.
Janmohamed SR, Brinkhuizen T, den Hollander JC, Madern GC, de Laat PC, van Steensel MA, Oranje AP
Clinical and experimental dermatology 2015 Jun;40(4):431-7
Clinical and experimental dermatology 2015 Jun;40(4):431-7
Hypoxia-activated chemotherapeutic TH-302 enhances the effects of VEGF-A inhibition and radiation on sarcomas.
Yoon C, Lee HJ, Park DJ, Lee YJ, Tap WD, Eisinger-Mathason TS, Hart CP, Choy E, Simon MC, Yoon SS
British journal of cancer 2015 Jun 30;113(1):46-56
British journal of cancer 2015 Jun 30;113(1):46-56
Effects of preset sequential administrations of sunitinib and everolimus on tumour differentiation in Caki-1 renal cell carcinoma.
Dos Santos C, Tijeras-Raballand A, Serova M, Sebbagh S, Slimane K, Faivre S, de Gramont A, Raymond E
British journal of cancer 2015 Jan 6;112(1):86-94
British journal of cancer 2015 Jan 6;112(1):86-94
Diffuse-type gastric cancer cells switch their driver pathways from FGFR2 signaling to SDF1/CXCR4 axis in hypoxic tumor microenvironments.
Kinoshita H, Yashiro M, Fukuoka T, Hasegawa T, Morisaki T, Kasashima H, Masuda G, Noda S, Hirakawa K
Carcinogenesis 2015 Dec;36(12):1511-20
Carcinogenesis 2015 Dec;36(12):1511-20
Fibrocyte-like cells mediate acquired resistance to anti-angiogenic therapy with bevacizumab.
Mitsuhashi A, Goto H, Saijo A, Trung VT, Aono Y, Ogino H, Kuramoto T, Tabata S, Uehara H, Izumi K, Yoshida M, Kobayashi H, Takahashi H, Gotoh M, Kakiuchi S, Hanibuchi M, Yano S, Yokomise H, Sakiyama S, Nishioka Y
Nature communications 2015 Dec 4;6:8792
Nature communications 2015 Dec 4;6:8792
Expression and diagnostic implications of carbonic anhydrase IX in several tumours with predominantly clear cell morphology.
Lin XY, Zhang H, Tang N, Zhang XP, Zhang W, Wang EH, Han YC
Histopathology 2015 Apr;66(5):685-94
Histopathology 2015 Apr;66(5):685-94
Expression of carbonic anhydrase 9 is a novel prognostic marker in resectable hepatocellular carcinoma.
Kang HJ, Kim IH, Sung CO, Shim JH, Yu E
Virchows Archiv : an international journal of pathology 2015 Apr;466(4):403-13
Virchows Archiv : an international journal of pathology 2015 Apr;466(4):403-13
HIF-1α and CA-IX as predictors of locoregional control for determining the optimal treatment modality for early-stage laryngeal carcinoma.
Kwon OJ, Park JJ, Ko GH, Seo JH, Jeong BK, Kang KM, Woo SH, Kim JP, Hwa JS, Carey TE
Head & neck 2015 Apr;37(4):505-10
Head & neck 2015 Apr;37(4):505-10
Hypoxia-inducible TAp73 supports tumorigenesis by regulating the angiogenic transcriptome.
Dulloo I, Phang BH, Othman R, Tan SY, Vijayaraghavan A, Goh LK, Martin-Lopez M, Marques MM, Li CW, Wang de Y, Marín MC, Xian W, McKeon F, Sabapathy K
Nature cell biology 2015 Apr;17(4):511-23
Nature cell biology 2015 Apr;17(4):511-23
Tumor microenvironmental changes induced by the sulfamate carbonic anhydrase IX inhibitor S4 in a laryngeal tumor model.
Meijer TW, Bussink J, Zatovicova M, Span PN, Lok J, Supuran CT, Kaanders JH
PloS one 2014;9(9):e108068
PloS one 2014;9(9):e108068
The role of Hypoxia-inducible factor-1 α , glucose transporter-1, (GLUT-1) and carbon anhydrase IX in endometrial cancer patients.
Sadlecki P, Bodnar M, Grabiec M, Marszalek A, Walentowicz P, Sokup A, Zegarska J, Walentowicz-Sadlecka M
BioMed research international 2014;2014:616850
BioMed research international 2014;2014:616850
PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia.
Mudie S, Bandarra D, Batie M, Biddlestone J, Moniz S, Ortmann B, Shmakova A, Rocha S
Cell cycle (Georgetown, Tex.) 2014;13(24):3878-91
Cell cycle (Georgetown, Tex.) 2014;13(24):3878-91
Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma.
Motzer RJ, Hutson TE, Hudes GR, Figlin RA, Martini JF, English PA, Huang X, Valota O, Williams JA
Cancer chemotherapy and pharmacology 2014 Oct;74(4):739-50
Cancer chemotherapy and pharmacology 2014 Oct;74(4):739-50
Monitoring hypoxia and vasculature during bevacizumab treatment in a murine colorectal cancer model.
Heijmen L, Ter Voert EG, Punt CJ, Heerschap A, Oyen WJ, Bussink J, Sweep CG, Laverman P, Span PN, de Geus-Oei LF, Boerman OC, van Laarhoven HW
Contrast media & molecular imaging 2014 May-Jun;9(3):237-45
Contrast media & molecular imaging 2014 May-Jun;9(3):237-45
Reoxygenation from chronic hypoxia promotes metastatic processes in pancreatic cancer through the Hedgehog signaling.
Morifuji Y, Onishi H, Iwasaki H, Imaizumi A, Nakano K, Tanaka M, Katano M
Cancer science 2014 Mar;105(3):324-33
Cancer science 2014 Mar;105(3):324-33
An expression signature of the angiogenic response in gastrointestinal neuroendocrine tumours: correlation with tumour phenotype and survival outcomes.
Pinato DJ, Tan TM, Toussi ST, Ramachandran R, Martin N, Meeran K, Ngo N, Dina R, Sharma R
British journal of cancer 2014 Jan 7;110(1):115-22
British journal of cancer 2014 Jan 7;110(1):115-22
Tbx1 regulates brain vascularization.
Cioffi S, Martucciello S, Fulcoli FG, Bilio M, Ferrentino R, Nusco E, Illingworth E
Human molecular genetics 2014 Jan 1;23(1):78-89
Human molecular genetics 2014 Jan 1;23(1):78-89
Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer.
Polański R, Hodgkinson CL, Fusi A, Nonaka D, Priest L, Kelly P, Trapani F, Bishop PW, White A, Critchlow SE, Smith PD, Blackhall F, Dive C, Morrow CJ
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Feb 15;20(4):926-937
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Feb 15;20(4):926-937
The diagnostic accuracy of percutaneous renal needle core biopsy and its potential impact on the clinical management of renal cortical neoplasms.
Gellert LL, Mehra R, Chen YB, Gopalan A, Fine SW, Al-Ahmadie H, Reuter VE, Tickoo SK
Archives of pathology & laboratory medicine 2014 Dec;138(12):1673-9
Archives of pathology & laboratory medicine 2014 Dec;138(12):1673-9
Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy.
Guo J, Shinriki S, Su Y, Nakamura T, Hayashi M, Tsuda Y, Murakami Y, Tasaki M, Hide T, Takezaki T, Kuratsu J, Yamashita S, Ueda M, Li JD, Ando Y, Jono H
Oncotarget 2014 Aug 15;5(15):6353-64
Oncotarget 2014 Aug 15;5(15):6353-64
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway.
Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y, Mai J, Shen H, Hu DZ, Adoro S, Hu B, Song M, Tan C, Landis MD, Ferrari M, Shin SJ, Brown M, Chang JC, Liu XS, Glimcher LH
Nature 2014 Apr 3;508(7494):103-107
Nature 2014 Apr 3;508(7494):103-107
Activation of AMP-Activated Protein Kinase α and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells.
Cho SY, Lee HJ, Lee HJ, Jung DB, Kim H, Sohn EJ, Kim B, Jung JH, Kwon BM, Kim SH
Evidence-based complementary and alternative medicine : eCAM 2013;2013:974313
Evidence-based complementary and alternative medicine : eCAM 2013;2013:974313
The use of porous scaffold as a tumor model.
Zhang M, Boughton P, Rose B, Lee CS, Hong AM
International journal of biomaterials 2013;2013:396056
International journal of biomaterials 2013;2013:396056
Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: a new concept of dual targeting drugs.
Dubois L, Peeters SG, van Kuijk SJ, Yaromina A, Lieuwes NG, Saraya R, Biemans R, Rami M, Parvathaneni NK, Vullo D, Vooijs M, Supuran CT, Winum JY, Lambin P
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2013 Sep;108(3):523-8
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2013 Sep;108(3):523-8
Are morphological criteria sufficient for the identification of circulating tumor cells in renal cancer?
El-Heliebi A, Kroneis T, Zöhrer E, Haybaeck J, Fischereder K, Kampel-Kettner K, Zigeuner R, Pock H, Riedl R, Stauber R, Geigl JB, Huppertz B, Sedlmayr P, Lackner C
Journal of translational medicine 2013 Sep 17;11:214
Journal of translational medicine 2013 Sep 17;11:214
Downregulation of PHLPP expression contributes to hypoxia-induced resistance to chemotherapy in colon cancer cells.
Wen YA, Stevens PD, Gasser ML, Andrei R, Gao T
Molecular and cellular biology 2013 Nov;33(22):4594-605
Molecular and cellular biology 2013 Nov;33(22):4594-605
Tubular von Hippel-Lindau knockout protects against rhabdomyolysis-induced AKI.
Fähling M, Mathia S, Paliege A, Koesters R, Mrowka R, Peters H, Persson PB, Neumayer HH, Bachmann S, Rosenberger C
Journal of the American Society of Nephrology : JASN 2013 Nov;24(11):1806-19
Journal of the American Society of Nephrology : JASN 2013 Nov;24(11):1806-19
Wnt/β-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1α signaling.
Zhang Q, Bai X, Chen W, Ma T, Hu Q, Liang C, Xie S, Chen C, Hu L, Xu S, Liang T
Carcinogenesis 2013 May;34(5):962-73
Carcinogenesis 2013 May;34(5):962-73
Hypoxia enhances the interaction between pancreatic stellate cells and cancer cells via increased secretion of connective tissue growth factor.
Eguchi D, Ikenaga N, Ohuchida K, Kozono S, Cui L, Fujiwara K, Fujino M, Ohtsuka T, Mizumoto K, Tanaka M
The Journal of surgical research 2013 May;181(2):225-33
The Journal of surgical research 2013 May;181(2):225-33
β1 integrin targeting potentiates antiangiogenic therapy and inhibits the growth of bevacizumab-resistant glioblastoma.
Carbonell WS, DeLay M, Jahangiri A, Park CC, Aghi MK
Cancer research 2013 May 15;73(10):3145-54
Cancer research 2013 May 15;73(10):3145-54
Immunohistochemical analysis of cancer stem cell markers in invasive breast carcinoma and associated ductal carcinoma in situ: relationships with markers of tumor hypoxia and microvascularity.
Currie MJ, Beardsley BE, Harris GC, Gunningham SP, Dachs GU, Dijkstra B, Morrin HR, Wells JE, Robinson BA
Human pathology 2013 Mar;44(3):402-11
Human pathology 2013 Mar;44(3):402-11
Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells.
Aarntzen EH, Srinivas M, Bonetto F, Cruz LJ, Verdijk P, Schreibelt G, van de Rakt M, Lesterhuis WJ, van Riel M, Punt CJ, Adema GJ, Heerschap A, Figdor CG, Oyen WJ, de Vries IJ
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Mar 15;19(6):1525-33
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Mar 15;19(6):1525-33
Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging.
Park I, Hu S, Bok R, Ozawa T, Ito M, Mukherjee J, Phillips JJ, James CD, Pieper RO, Ronen SM, Vigneron DB, Nelson SJ
Magnetic resonance in medicine 2013 Jul;70(1):33-9
Magnetic resonance in medicine 2013 Jul;70(1):33-9
Renal CD133(+)/CD73(+) progenitors produce erythropoietin under hypoxia and prolyl hydroxylase inhibition.
Bussolati B, Lauritano C, Moggio A, Collino F, Mazzone M, Camussi G
Journal of the American Society of Nephrology : JASN 2013 Jul;24(8):1234-41
Journal of the American Society of Nephrology : JASN 2013 Jul;24(8):1234-41
EG-VEGF controls placental growth and survival in normal and pathological pregnancies: case of fetal growth restriction (FGR).
Brouillet S, Murthi P, Hoffmann P, Salomon A, Sergent F, De Mazancourt P, Dakouane-Giudicelli M, Dieudonné MN, Rozenberg P, Vaiman D, Barbaux S, Benharouga M, Feige JJ, Alfaidy N
Cellular and molecular life sciences : CMLS 2013 Feb;70(3):511-25
Cellular and molecular life sciences : CMLS 2013 Feb;70(3):511-25
Steep increase in myonuclear domain size during infancy.
Delhaas T, Van der Meer SF, Schaart G, Degens H, Drost MR
Anatomical record (Hoboken, N.J. : 2007) 2013 Feb;296(2):192-7
Anatomical record (Hoboken, N.J. : 2007) 2013 Feb;296(2):192-7
Immunohistochemical markers of the hypoxic response can identify malignancy in phaeochromocytomas and paragangliomas and optimize the detection of tumours with VHL germline mutations.
Pinato DJ, Ramachandran R, Toussi ST, Vergine M, Ngo N, Sharma R, Lloyd T, Meeran K, Palazzo F, Martin N, Khoo B, Dina R, Tan TM
British journal of cancer 2013 Feb 5;108(2):429-37
British journal of cancer 2013 Feb 5;108(2):429-37
Tumor dynamics in response to antiangiogenic therapy with oral metronomic topotecan and pazopanib in neuroblastoma xenografts.
Kumar S, Mokhtari RB, Oliveira ID, Islam S, Toledo SR, Yeger H, Baruchel S
Translational oncology 2013 Aug;6(4):493-503
Translational oncology 2013 Aug;6(4):493-503
Tumor dynamics in response to antiangiogenic therapy with oral metronomic topotecan and pazopanib in neuroblastoma xenografts.
Kumar S, Mokhtari RB, Oliveira ID, Islam S, Toledo SR, Yeger H, Baruchel S
Translational oncology 2013 Aug;6(4):493-503
Translational oncology 2013 Aug;6(4):493-503
Characterization of different osteosarcoma phenotypes by PET imaging in preclinical animal models.
Campanile C, Arlt MJ, Krämer SD, Honer M, Gvozdenovic A, Brennecke P, Fischer CR, Sabile AA, Müller A, Ametamey SM, Born W, Schibli R, Fuchs B
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013 Aug;54(8):1362-8
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013 Aug;54(8):1362-8
Monitoring the effects of bevacizumab beyond progression in a murine colorectal cancer model: a functional imaging approach.
Heijmen L, Punt CJ, Ter Voert EG, de Geus-Oei LF, Heerschap A, Bussink J, Sweep CG, Zerbi V, Oyen WJ, Span PN, Boerman O, van Laarhoven HW
Investigational new drugs 2013 Aug;31(4):881-90
Investigational new drugs 2013 Aug;31(4):881-90
The expression of the hypoxia markers CA9 and CXCR4 is correlated with survival in patients with neuroendocrine tumours of the ileum.
Deschamps L, Bacha D, Rebours V, Mebarki M, Bretagnol F, Panis Y, Bedossa P, Ruszniewski P, Couvelard A
Neuroendocrinology 2012;95(3):214-22
Neuroendocrinology 2012;95(3):214-22
Increased microglia/macrophage gene expression in a subset of adult and pediatric astrocytomas.
Engler JR, Robinson AE, Smirnov I, Hodgson JG, Berger MS, Gupta N, James CD, Molinaro A, Phillips JJ
PloS one 2012;7(8):e43339
PloS one 2012;7(8):e43339
SIRT3 protects from hypoxia and staurosporine-mediated cell death by maintaining mitochondrial membrane potential and intracellular pH.
Pellegrini L, Pucci B, Villanova L, Marino ML, Marfe G, Sansone L, Vernucci E, Bellizzi D, Reali V, Fini M, Russo MA, Tafani M
Cell death and differentiation 2012 Nov;19(11):1815-25
Cell death and differentiation 2012 Nov;19(11):1815-25
Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype.
Piao Y, Liang J, Holmes L, Zurita AJ, Henry V, Heymach JV, de Groot JF
Neuro-oncology 2012 Nov;14(11):1379-92
Neuro-oncology 2012 Nov;14(11):1379-92
Function of carbonic anhydrase IX in glioblastoma multiforme.
Proescholdt MA, Merrill MJ, Stoerr EM, Lohmeier A, Pohl F, Brawanski A
Neuro-oncology 2012 Nov;14(11):1357-66
Neuro-oncology 2012 Nov;14(11):1357-66
Increased activation of the hypoxia-inducible factor pathway in varicose veins.
Lim CS, Kiriakidis S, Paleolog EM, Davies AH
Journal of vascular surgery 2012 May;55(5):1427-39
Journal of vascular surgery 2012 May;55(5):1427-39
Molecular profiling of pancreatic neuroendocrine tumors in sporadic and Von Hippel-Lindau patients.
Speisky D, Duces A, Bièche I, Rebours V, Hammel P, Sauvanet A, Richard S, Bedossa P, Vidaud M, Murat A, Niccoli P, Scoazec JY, Ruszniewski P, Couvelard A, GTE Group, Groupe d'Etude des Tumeurs Endocrines.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 May 15;18(10):2838-49
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 May 15;18(10):2838-49
Inclusive estimation of complex antigen presentation functions of monocyte-derived dendritic cells differentiated under normoxia and hypoxia conditions.
Ogino T, Onishi H, Suzuki H, Morisaki T, Tanaka M, Katano M
Cancer immunology, immunotherapy : CII 2012 Mar;61(3):409-24
Cancer immunology, immunotherapy : CII 2012 Mar;61(3):409-24
Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1.
Wang Y, Roche O, Xu C, Moriyama EH, Heir P, Chung J, Roos FC, Chen Y, Finak G, Milosevic M, Wilson BC, Teh BT, Park M, Irwin MS, Ohh M
Proceedings of the National Academy of Sciences of the United States of America 2012 Mar 27;109(13):4892-7
Proceedings of the National Academy of Sciences of the United States of America 2012 Mar 27;109(13):4892-7
Morphophenotypic characteristics of intralymphatic cancer and stromal cells susceptible to lymphogenic metastasis.
Matsumura Y, Ishii G, Aokage K, Kuwata T, Hishida T, Yoshida J, Nishimura M, Nagai K, Ochiai A
Cancer science 2012 Jul;103(7):1342-7
Cancer science 2012 Jul;103(7):1342-7
Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer.
Onishi H, Morifuji Y, Kai M, Suyama K, Iwasaki H, Katano M
Cancer science 2012 Jul;103(7):1272-9
Cancer science 2012 Jul;103(7):1272-9
Diflavin oxidoreductases activate the bioreductive prodrug PR-104A under hypoxia.
Guise CP, Abbattista MR, Tipparaju SR, Lambie NK, Su J, Li D, Wilson WR, Dachs GU, Patterson AV
Molecular pharmacology 2012 Jan;81(1):31-40
Molecular pharmacology 2012 Jan;81(1):31-40
Lowered expression of galectin-2 is associated with lymph node metastasis in gastric cancer.
Jung JH, Kim HJ, Yeom J, Yoo C, Shin J, Yoo J, Kang CS, Lee C
Journal of gastroenterology 2012 Jan;47(1):37-48
Journal of gastroenterology 2012 Jan;47(1):37-48
Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma.
Chaumeil MM, Ozawa T, Park I, Scott K, James CD, Nelson SJ, Ronen SM
NeuroImage 2012 Jan 2;59(1):193-201
NeuroImage 2012 Jan 2;59(1):193-201
Prognostic value of the chemokine receptor CXCR4 and epithelial-to-mesenchymal transition in patients with squamous cell carcinoma of the mobile tongue.
Albert S, Hourseau M, Halimi C, Serova M, Descatoire V, Barry B, Couvelard A, Riveiro ME, Tijeras-Raballand A, de Gramont A, Raymond E, Faivre S
Oral oncology 2012 Dec;48(12):1263-71
Oral oncology 2012 Dec;48(12):1263-71
Predictive factors for response to treatment in patients with advanced renal cell carcinoma.
Muriel López C, Esteban E, Astudillo A, Pardo P, Berros JP, Izquierdo M, Crespo G, Fonseca PJ, Sanmamed M, Martínez-Camblor P
Investigational new drugs 2012 Dec;30(6):2443-9
Investigational new drugs 2012 Dec;30(6):2443-9
Prognostic factors in patients with advanced renal cell carcinoma.
Muriel López C, Esteban E, Berros JP, Pardo P, Astudillo A, Izquierdo M, Crespo G, Sanmamed M, Fonseca PJ, Martínez-Camblor P
Clinical genitourinary cancer 2012 Dec;10(4):262-70
Clinical genitourinary cancer 2012 Dec;10(4):262-70
Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.
Yin S, Kaluz S, Devi NS, Jabbar AA, de Noronha RG, Mun J, Zhang Z, Boreddy PR, Wang W, Wang Z, Abbruscato T, Chen Z, Olson JJ, Zhang R, Goodman MM, Nicolaou KC, Van Meir EG
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Dec 15;18(24):6623-33
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Dec 15;18(24):6623-33
Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers.
Fromy B, Lingueglia E, Sigaudo-Roussel D, Saumet JL, Lazdunski M
Nature medicine 2012 Aug;18(8):1205-7
Nature medicine 2012 Aug;18(8):1205-7
Characterization of the Tumor-Microenvironment in Patient-Derived Cervix Xenografts (OCICx).
Chaudary N, Pintilie M, Schwock J, Dhani N, Clarke B, Milosevic M, Fyles A, Hill RP
Cancers 2012 Aug 29;4(3):821-45
Cancers 2012 Aug 29;4(3):821-45
The prognostic value of expression of HIF1α, EGFR and VEGF-A, in localized prostate cancer for intermediate- and high-risk patients treated with radiation therapy with or without androgen deprivation therapy.
Weber DC, Tille JC, Combescure C, Egger JF, Laouiti M, Hammad K, Granger P, Rubbia-Brandt L, Miralbell R
Radiation oncology (London, England) 2012 Apr 30;7:66
Radiation oncology (London, England) 2012 Apr 30;7:66
Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104.
Benito J, Shi Y, Szymanska B, Carol H, Boehm I, Lu H, Konoplev S, Fang W, Zweidler-McKay PA, Campana D, Borthakur G, Bueso-Ramos C, Shpall E, Thomas DA, Jordan CT, Kantarjian H, Wilson WR, Lock R, Andreeff M, Konopleva M
PloS one 2011;6(8):e23108
PloS one 2011;6(8):e23108
Hypoxia-inducible factor-1α mRNA: a new target for destabilization by tristetraprolin in endothelial cells.
Chamboredon S, Ciais D, Desroches-Castan A, Savi P, Bono F, Feige JJ, Cherradi N
Molecular biology of the cell 2011 Sep;22(18):3366-78
Molecular biology of the cell 2011 Sep;22(18):3366-78
Investigation on tumor hypoxia in resectable primary prostate cancer as demonstrated by 18F-FAZA PET/CT utilizing multimodality fusion techniques.
Garcia-Parra R, Wood D, Shah RB, Siddiqui J, Hussain H, Park H, Desmond T, Meyer C, Piert M
European journal of nuclear medicine and molecular imaging 2011 Oct;38(10):1816-23
European journal of nuclear medicine and molecular imaging 2011 Oct;38(10):1816-23
The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH.
Melvin A, Mudie S, Rocha S
Molecular biology of the cell 2011 Nov;22(21):4171-81
Molecular biology of the cell 2011 Nov;22(21):4171-81
Angiogenesis and host immune response contribute to the aggressive character of non-melanoma skin cancers in renal transplant recipients.
Mackenzie KA, Miller AP, Hock BD, Gardner J, Simcock JW, Roake JA, Dachs GU, Robinson BA, Currie MJ
Histopathology 2011 May;58(6):875-85
Histopathology 2011 May;58(6):875-85
Role of immunohistochemistry in the evaluation of needle core biopsies in adult renal cortical tumors: an ex vivo study.
Al-Ahmadie HA, Alden D, Fine SW, Gopalan A, Touijer KA, Russo P, Reuter VE, Tickoo SK
The American journal of surgical pathology 2011 Jul;35(7):949-61
The American journal of surgical pathology 2011 Jul;35(7):949-61
Role of hypoxia and EGF on expression, activity, localization and phosphorylation of carbonic anhydrase IX in MDA-MB-231 breast cancer cells.
Li Y, Wang H, Tu C, Shiverick KT, Silverman DN, Frost SC
Biochimica et biophysica acta 2011 Jan;1813(1):159-67
Biochimica et biophysica acta 2011 Jan;1813(1):159-67
IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina.
Nelson MP, Christmann BS, Werner JL, Metz AE, Trevor JL, Lowell CA, Steele C
Journal of immunology (Baltimore, Md. : 1950) 2011 Feb 15;186(4):2372-81
Journal of immunology (Baltimore, Md. : 1950) 2011 Feb 15;186(4):2372-81
Expression of a hypoxia-associated protein, carbonic anhydrase-9, correlates with malignant phenotypes of gastric carcinoma.
Kato Y, Yashiro M, Noda S, Kashiwagi S, Matsuoka J, Fuyuhiro Y, Doi Y, Hirakawa K
Digestion 2010;82(4):246-51
Digestion 2010;82(4):246-51
Distinguishing clear cell renal cell carcinoma, retroperitoneal paraganglioma, and adrenal cortical lesions on limited biopsy material: utility of immunohistochemical markers.
Lapinski JE, Chen L, Zhou M
Applied immunohistochemistry & molecular morphology : AIMM 2010 Oct;18(5):414-21
Applied immunohistochemistry & molecular morphology : AIMM 2010 Oct;18(5):414-21
A profile of prognostic and molecular factors in European and Māori breast cancer patients.
Dachs GU, Kano M, Volkova E, Morrin HR, Davey VC, Harris GC, Cheale M, Frampton C, Currie MJ, Wells JE, Robinson BA
BMC cancer 2010 Oct 10;10:543
BMC cancer 2010 Oct 10;10:543
Interaction of hypoxia-inducible factor-1α and Notch signaling regulates medulloblastoma precursor proliferation and fate.
Pistollato F, Rampazzo E, Persano L, Abbadi S, Frasson C, Denaro L, D'Avella D, Panchision DM, Della Puppa A, Scienza R, Basso G
Stem cells (Dayton, Ohio) 2010 Nov;28(11):1918-29
Stem cells (Dayton, Ohio) 2010 Nov;28(11):1918-29
Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection.
Newton IP, Kenneth NS, Appleton PL, Näthke I, Rocha S
Molecular biology of the cell 2010 Nov 1;21(21):3630-8
Molecular biology of the cell 2010 Nov 1;21(21):3630-8
Intratumoral hypoxic gradient drives stem cells distribution and MGMT expression in glioblastoma.
Pistollato F, Abbadi S, Rampazzo E, Persano L, Della Puppa A, Frasson C, Sarto E, Scienza R, D'avella D, Basso G
Stem cells (Dayton, Ohio) 2010 May;28(5):851-62
Stem cells (Dayton, Ohio) 2010 May;28(5):851-62
Hypoxia stimulates CXCR4 signalling in ileal carcinoids.
Arvidsson Y, Bergström A, Arvidsson L, Kristiansson E, Ahlman H, Nilsson O
Endocrine-related cancer 2010 Jun;17(2):303-16
Endocrine-related cancer 2010 Jun;17(2):303-16
Carbonic anhydrase IX in renal cell carcinoma: implications for prognosis, diagnosis, and therapy.
Stillebroer AB, Mulders PF, Boerman OC, Oyen WJ, Oosterwijk E
European urology 2010 Jul;58(1):75-83
European urology 2010 Jul;58(1):75-83
Quantification of carbonic anhydrase IX expression in serum and tissue of renal cell carcinoma patients using enzyme-linked immunosorbent assay: prognostic and diagnostic potentials.
Zhou GX, Ireland J, Rayman P, Finke J, Zhou M
Urology 2010 Feb;75(2):257-61
Urology 2010 Feb;75(2):257-61
Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors.
Park I, Larson PE, Zierhut ML, Hu S, Bok R, Ozawa T, Kurhanewicz J, Vigneron DB, Vandenberg SR, James CD, Nelson SJ
Neuro-oncology 2010 Feb;12(2):133-44
Neuro-oncology 2010 Feb;12(2):133-44
Molecular markers associated with response to chemotherapy in gastro-entero-pancreatic neuroendocrine tumors.
O'Toole D, Couvelard A, Rebours V, Zappa M, Hentic O, Hammel P, Levy P, Bedossa P, Raymond E, Ruszniewski P
Endocrine-related cancer 2010 Dec;17(4):847-56
Endocrine-related cancer 2010 Dec;17(4):847-56
Identification of a novel small molecule HIF-1alpha translation inhibitor.
Narita T, Yin S, Gelin CF, Moreno CS, Yepes M, Nicolaou KC, Van Meir EG
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Oct 1;15(19):6128-36
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Oct 1;15(19):6128-36
gammaH2AX expression in tumors exposed to cisplatin and fractionated irradiation.
Bañuelos CA, Banáth JP, Kim JY, Aquino-Parsons C, Olive PL
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 May 15;15(10):3344-53
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 May 15;15(10):3344-53
Tissue biomarkers in renal cell carcinoma: issues and solutions.
Di Napoli A, Signoretti S
Cancer 2009 May 15;115(10 Suppl):2290-7
Cancer 2009 May 15;115(10 Suppl):2290-7
Plant morphogenesis: a role for mechanical signals.
Dumais J
Current biology : CB 2009 Mar 10;19(5):R207-8
Current biology : CB 2009 Mar 10;19(5):R207-8
Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma.
Nakao M, Ishii G, Nagai K, Kawase A, Kenmotsu H, Kon-No H, Hishida T, Nishimura M, Yoshida J, Ochiai A
Cancer 2009 Jun 15;115(12):2732-43
Cancer 2009 Jun 15;115(12):2732-43
Expression and activity of carbonic anhydrase IX is associated with metabolic dysfunction in MDA-MB-231 breast cancer cells.
Li Y, Wang H, Oosterwijk E, Tu C, Shiverick KT, Silverman DN, Frost SC
Cancer investigation 2009 Jul;27(6):613-23
Cancer investigation 2009 Jul;27(6):613-23
Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation.
Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Kondo S, Wang H, Wang H, Yeung SC, Lee MH
The American journal of pathology 2009 Jul;175(1):400-11
The American journal of pathology 2009 Jul;175(1):400-11
Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization.
Loinard C, Ginouvès A, Vilar J, Cochain C, Zouggari Y, Recalde A, Duriez M, Lévy BI, Pouysségur J, Berra E, Silvestre JS
Circulation 2009 Jul 7;120(1):50-9
Circulation 2009 Jul 7;120(1):50-9
Carbonic anhydrase 9 is a predictive marker of survival benefit from lower dose of bevacizumab in patients with previously treated metastatic colorectal cancer.
Hong YS, Cho HJ, Kim SY, Jung KH, Park JW, Choi HS, Oh JH, Kim BC, Sohn DK, Kim DY, Chang HJ
BMC cancer 2009 Jul 21;9:246
BMC cancer 2009 Jul 21;9:246
Mediators of glioblastoma resistance and invasion during antivascular endothelial growth factor therapy.
Lucio-Eterovic AK, Piao Y, de Groot JF
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Jul 15;15(14):4589-99
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Jul 15;15(14):4589-99
Antibody-specific detection of CAIX in breast and prostate cancers.
Li Y, Wang H, Oosterwijk E, Selman Y, Mira JC, Medrano T, Shiverick KT, Frost SC
Biochemical and biophysical research communications 2009 Aug 28;386(3):488-92
Biochemical and biophysical research communications 2009 Aug 28;386(3):488-92
Carbonic anhydrase IX expression in clear cell renal cell carcinoma: an immunohistochemical study comparing 2 antibodies.
Al-Ahmadie HA, Alden D, Qin LX, Olgac S, Fine SW, Gopalan A, Russo P, Motzer RJ, Reuter VE, Tickoo SK
The American journal of surgical pathology 2008 Mar;32(3):377-82
The American journal of surgical pathology 2008 Mar;32(3):377-82
Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection.
Gauter-Fleckenstein B, Fleckenstein K, Owzar K, Jiang C, Batinic-Haberle I, Vujaskovic Z
Free radical biology & medicine 2008 Mar 15;44(6):982-9
Free radical biology & medicine 2008 Mar 15;44(6):982-9
Brachytherapy for oral tongue cancer: an analysis of treatment results with various biological markers.
Sakata K, Someya M, Nagakura H, Nakata K, Oouchi A, Takagi M, Hareyama M
Japanese journal of clinical oncology 2008 Jun;38(6):402-7
Japanese journal of clinical oncology 2008 Jun;38(6):402-7
Tumor necrosis is associated with increased alphavbeta3 integrin expression and poor prognosis in nodular cutaneous melanomas.
Bachmann IM, Ladstein RG, Straume O, Naumov GN, Akslen LA
BMC cancer 2008 Dec 5;8:362
BMC cancer 2008 Dec 5;8:362
Carbonic anhydrase IX expression in clear cell renal cell carcinomas negatively correlates with the proportion of the granular cell component.
Skapa P, Hyrsl L, Zavada J, Soukup J, Zamecnik J
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008 Aug 1;26(22):3809-11; author reply 3811-2
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008 Aug 1;26(22):3809-11; author reply 3811-2
An orthotopic skull base model of malignant meningioma.
Baia GS, Dinca EB, Ozawa T, Kimura ET, McDermott MW, James CD, VandenBerg SR, Lal A
Brain pathology (Zurich, Switzerland) 2008 Apr;18(2):172-9
Brain pathology (Zurich, Switzerland) 2008 Apr;18(2):172-9
Hypoxia can be detected in irradiated normal human tissue: a study using the hypoxic marker pimonidazole hydrochloride.
Westbury CB, Pearson A, Nerurkar A, Reis-Filho JS, Steele D, Peckitt C, Sharp G, Yarnold JR
The British journal of radiology 2007 Nov;80(959):934-8
The British journal of radiology 2007 Nov;80(959):934-8
Is the downregulation of EphB2 receptor expression during colorectal tumorigenesis due to hypoxia?
Kaidi A, Moorghen M, Williams AC, Paraskeva C
Gut 2007 Nov;56(11):1637-8
Gut 2007 Nov;56(11):1637-8
Expression of the hypoxia marker carbonic anhydrase 9 is associated with anaplastic phenotypes in meningiomas.
Yoo H, Baia GS, Smith JS, McDermott MW, Bollen AW, Vandenberg SR, Lamborn KR, Lal A
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Jan 1;13(1):68-75
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Jan 1;13(1):68-75
Angiogenesis and hypoxia in lymph node metastases is predicted by the angiogenesis and hypoxia in the primary tumour in patients with breast cancer.
Van den Eynden GG, Van der Auwera I, Van Laere SJ, Colpaert CG, Turley H, Harris AL, van Dam P, Dirix LY, Vermeulen PB, Van Marck EA
British journal of cancer 2005 Nov 14;93(10):1128-36
British journal of cancer 2005 Nov 14;93(10):1128-36
Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer.
Atkins M, Regan M, McDermott D, Mier J, Stanbridge E, Youmans A, Febbo P, Upton M, Lechpammer M, Signoretti S
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 May 15;11(10):3714-21
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 May 15;11(10):3714-21
[Recent evaluation of a Candida hemagglutination test].
Müller J
Mycoses 1991;34 Suppl 1:63-7
Mycoses 1991;34 Suppl 1:63-7
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Supportive validation
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- Simple Western: Carbonic Anhydrase IX/CA9 Antibody [NB100-417] - Simple Western lane view shows a specific band for CAIX in 0.1 mg/mL of HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.
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- Western Blot: Carbonic Anhydrase IX/CA9 Antibody [NB100-417] - Analysis in 1) HeLa, 2) MDA-MB-231, and 3) A549 whole cell lysates. Specific bands were detected for Carbonic Anhydrase IX/CA9 at a molecular weight of 50 kDa.
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- Western Blot: Carbonic Anhydrase IX/CA9 Antibody [NB100-417] - Analysis on various human cell lysates. Specific bands were detected for Carbonic Anhydrase IX/CA9 in HEK-293 and A498 cell lines at a molecular weight of approximately 50 kDa. WB image submitted by a verified customer review.
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- Western Blot: Carbonic Anhydrase IX/CA9 Antibody [NB100-417] - Analysis on rat renal cortex. A specific band was detected at a molecular weight of approximately 50 kDa.
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- Western Blot: Carbonic Anhydrase IX/CA9 Antibody [NB100-417] - Analysis using the HRP conjugate. Analysis in transfected HEK cell lysate. Rabbit IgG was used as a negative control.
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- Immunohistochemistry: Carbonic Anhydrase IX/CA9 Antibody [NB100-417] - Analysis using the Biotin conjugate. Staining of Renal carcinoma tissue.
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- Immunohistochemistry-Frozen: Carbonic Anhydrase IX/CA9 Antibody [NB100-417] - Analysis of human colon carcinoma, xenografted in mice. IHC-Fr image submitted by a verified customer review.
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- Immunohistochemistry-Paraffin: Carbonic Anhydrase IX/CA9 Antibody [NB100-417] - IHC analysis of a FFPE tissue section of human breast cancer using CAIX antibody at 1:1000 dilution. The primary antibody bound to CAIX antigens in the tissue section was detected using a HRP labeled secondary antibody and DAB reagent. Nuclei of the cells were counterstained with hematoxylin. This CAIX antibody generated an expected cytoplasmic staining of CAIX protein with an intense signal around the cellular membranes in tumor cores. The latter are more likely to be hypoxic in growing tumors which signifies that the observed CAIX staining is specific.
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- Immunohistochemistry: Carbonic Anhydrase IX/CA9 Antibody [NB100-417] - Immunofluorescence of human RCC tumor cryosections using NB100-417 (Panel A). Panel B shows staining with normal rabbit serum.
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- Immunohistochemistry: Carbonic Anhydrase IX/CA9 Antibody [NB100-417] - Immunohistochemical representative microphotographs representing the HIF-1alpha, GLUT-1, and CAIX expression in endometrial cancer according to FIGO classification (IA, IB, II, IIIA, IIIC, and IV). Primary objective magnification 20x. Image collected and cropped by CiteAb from the following publication (http://www.hindawi.com/journals/bmri/2014/616850/) licensed under a CC-BY licence.
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- Immunohistochemistry: Carbonic Anhydrase IX/CA9 Antibody [NB100-417] - Colorectal cancer xenograft growth was suppressed by CB-PIC(20 and 50 mg/kg body weight) in female athymic nude mice. Starting three days after SW620 cell inoculation, CB-PIC (20 and 50 mg/kg body weight) was injected in abdomen with 4% Tween 20 as vehicle once daily. Representative examples of immunohistochemical staining for CA IX in tumor section. Image collected and cropped by CiteAb from the following publication (http://www.hindawi.com/journals/ecam/2013/974313/), licensed under a CC-BY licence.
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- Immunohistochemistry: Carbonic Anhydrase IX/CA9 Antibody [NB100-417] - Images showing Carbonic Anhydrase IX/CA9 expression, pimonidazole, apoptosis and proliferation in SCCNij202.Carbonic Anhydrase IX/CA9 is expressed in hypoxic regions as assessed by pimonidazole staining (A), but is also observed in non-pimonidazole areas (B). Yet, most of Carbonic Anhydrase IX/CA9 is expressed in pimonidazole positive regions (C). Proliferation (BrdUrd) and apoptosis (caspase-3) in relation to Carbonic Anhydrase IX/CA9 expression are shown in figure D and E. Red, Carbonic Anhydrase IX/CA9; Green, pimonidazole (A-B), BrdUrd (D) or caspase-3 (E); Yellow, overlap of Carbonic Anhydrase IX/CA9 (red) and pimonidazole (green); Light blue, vessels. Magnification 100x. Scale bars represent 100 um. Closed circles represent Carbonic Anhydrase IX/CA9 expression in pimonidazole positive regions; open circles represent Carbonic Anhydrase IX/CA9 expression in pimonidazole negative regions. Image collected and cropped by CiteAb from the following publication (http://dx.plos.org/10.1371/journal.pone.0108068), licensed under a CC-BY licence.
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- Immunohistochemistry-Paraffin: Carbonic Anhydrase IX/CA9 Antibody [NB100-417] - Strong cytoplasmic and membranous CA9 staining in glandular cells of human stomach tissue. Citrate buffer pH 6 antigen retrieval. Antibody at 1:250 dilution and detected with an Alexa Fluor 546 labeled goat-anti-rabbit secondary antibody. Nuclei detected with DAPI. IHC-P image submitted by a verified customer review.
Supportive validation
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- Flow Cytometry: Carbonic Anhydrase IX/CA9 Antibody [NB100-417] - An intracellular stain was performed on U-87 MG Cells with NB100-417 and a matched isotype control. Cells were fixed with 4% PFA and then permeablized with 0.1% saponin. Cells were incubated in an antibody dilution of 2.5 ug/mL for 30 minutes at room temperature, followed by Rabbit IgG APC-conjugated Secondary Antibody, (R&D Systems, F0111).
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- Immunoblotting: Carbonic Anhydrase IX/CA9 Antibody [NB100-417] - Hypoxias impact on proteins of the mitochondrial ISC assembly machinery. (A) Immunoblotting analyzed the total protein extracts from HeLa cells grown in normoxia (Nx, 21% O2) or hypoxia (Hx, 1% O2) conditions using VDACs poly antibody and anti-CAIX, -ISCU, -FXN, -NFS1, -HSC20 antibodies. Beta-Actin was used as loading control. Citation: Ferecatu I, Canal F, Fabbri L, Mazure NM, Bouton C, Golinelli-Cohen M-P (2018) Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1 alpha activation. PLoS ONE 13(3): e0194782.
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- Immunoblotting: Carbonic Anhydrase IX/CA9 Antibody [NB100-417] - Iron depletion and nitric oxide stress and Iron depletion induce the truncated VDAC1 form accumulation. (D) Total protein extracts were analyzed by immunoblotting using VDACs poly antibody and anti-HIF-1 alpha and -CAIX antibodies. (E) Immunoblotting was used to analyze total protein extracts using antibodies against the three VDAC isoforms. (F) HeLa cells were grown in hypoxia (Hx, 1% O2) conditions and transfected with iscu- or NC-siRNA for 3 days, or grown in normoxia (Nx, 21% O2), some treated with DFO for 16 h. Western Blots analyzed total proteins using VDACs poly antibody and anti-HIF-1 alpha, -CAIX, -ISCU antibodies. Citation: Ferecatu I, Canal F, Fabbri L, Mazure NM, Bouton C, Golinelli-Cohen M-P (2018) Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1 alpha activation. PLoS ONE 13(3): e0194782.
