ALX-210-917-C050

antibody from Enzo Life Sciences

Targeting: SET 2PP2A, IGAAD, IPP2A2, PHAPII, TAF-I, TAF-IBETA

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

ALX-210-917-C050

Provider

Enzo Life Sciences

Proper citation

Enzo Life Sciences Cat#ALX-210-917-C050, RRID:AB_2052547

Product name

SET (human) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic peptide

Description

Protein A affinity-purified.

Reactivity

Human

Host

Rabbit

Vial size

50 μg

Storage

-20°C

Handling

Avoid freeze/thaw cycles.

References

Submitted references

Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis.

Martinvalet D, Zhu P, Lieberman J
Immunity 2005 Mar;22(3):355-70

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Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor.

Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J
Cell 2003 Mar 7;112(5):659-72

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Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.

Fan Z, Beresford PJ, Zhang D, Xu Z, Novina CD, Yoshida A, Pommier Y, Lieberman J
Nature immunology 2003 Feb;4(2):145-53

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HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A.

Fan Z, Beresford PJ, Zhang D, Lieberman J
Molecular and cellular biology 2002 Apr;22(8):2810-20

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Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks.

Beresford PJ, Zhang D, Oh DY, Fan Z, Greer EL, Russo ML, Jaju M, Lieberman J
The Journal of biological chemistry 2001 Nov 16;276(46):43285-93