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- Antibody Data
- Antigen structure
- References [26]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 17509-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17509-1-AP, RRID:AB_10596914
- Product name
- IRS1 antibody
- Antibody type
- Polyclonal
- Description
- IRS1 antibody (Cat. #17509-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Pentadecanoic acid promotes basal and insulin-stimulated glucose uptake in C2C12 myotubes.
The Roles of Liver Inflammation and the Insulin Signaling Pathway in PM2.5 Instillation-Induced Insulin Resistance in Wistar Rats.
BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation.
Nano chitosan-zinc complex improves the growth performance and antioxidant capacity of the small intestine in weaned piglets.
Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats.
KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis.
Programmed cell death 5 improves skeletal muscle insulin resistance by inhibiting IRS-1 ubiquitination through stabilization of MDM2.
Effects of Chronic Secondhand Smoke (SHS) Exposure on Cognitive Performance and Metabolic Pathways in the Hippocampus of Wild-Type and Human Tau Mice.
Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.
Aptamer-SH2 superbinder-based targeted therapy for pancreatic ductal adenocarcinoma.
A maternal high-fat/low-fiber diet impairs glucose tolerance and induces the formation of glycolytic muscle fibers in neonatal offspring.
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
CEBPG promotes esophageal squamous cell carcinoma progression by enhancing PI3K-AKT signaling.
miR-203 inhibits cell proliferation and ERK pathway in prostate cancer by targeting IRS-1.
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
Prenatal High-Salt Diet-Induced Metabolic Disorders via Decreasing Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α in Adult Male Rat Offspring.
Hydroxychloroquine Improves Obesity-Associated Insulin Resistance and Hepatic Steatosis by Regulating Lipid Metabolism.
Suppression of miR-143 contributes to overexpression of IL-6, HIF-1α and NF-κB p65 in Cr(VI)-induced human exposure and tumor growth.
Therapeutic potential of NaoXinTong Capsule on the developed diabetic nephropathy in db/db mice.
Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.
Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala.
DJ-1 Deficiency Protects Hepatic Steatosis by Enhancing Fatty Acid Oxidation in Mice.
miR-146b Inhibits Glucose Consumption by Targeting IRS1 Gene in Porcine Primary Adipocytes.
NaoXinTong Capsules inhibit the development of diabetic nephropathy in db/db mice.
Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy.
Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy.
Fu WC, Li HY, Li TT, Yang K, Chen JX, Wang SJ, Liu CH, Zhang W
Food & nutrition research 2021;65
Food & nutrition research 2021;65
The Roles of Liver Inflammation and the Insulin Signaling Pathway in PM2.5 Instillation-Induced Insulin Resistance in Wistar Rats.
Zhang Z, Hu S, Fan P, Li L, Feng S, Xiao H, Zhu L
Disease markers 2021;2021:2821673
Disease markers 2021;2021:2821673
BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation.
da Silva Rosa SC, Martens MD, Field JT, Nguyen L, Kereliuk SM, Hai Y, Chapman D, Diehl-Jones W, Aliani M, West AR, Thliveris J, Ghavami S, Rampitsch C, Dolinsky VW, Gordon JW
Autophagy 2021 Sep;17(9):2257-2272
Autophagy 2021 Sep;17(9):2257-2272
Nano chitosan-zinc complex improves the growth performance and antioxidant capacity of the small intestine in weaned piglets.
Zhang M, Hou G, Hu P, Feng D, Wang J, Zhu W
The British journal of nutrition 2021 Sep 28;126(6):801-812
The British journal of nutrition 2021 Sep 28;126(6):801-812
Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats.
Cheng YC, Chiu YM, Dai ZK, Wu BN
Cells 2021 Oct 8;10(10)
Cells 2021 Oct 8;10(10)
KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis.
Senoo H, Murata D, Wai M, Arai K, Iwata W, Sesaki H, Iijima M
Molecular cell 2021 Nov 18;81(22):4622-4634.e8
Molecular cell 2021 Nov 18;81(22):4622-4634.e8
Programmed cell death 5 improves skeletal muscle insulin resistance by inhibiting IRS-1 ubiquitination through stabilization of MDM2.
Li B, Ye J, Liu R, Weng L, Cao Y, Jia S, Xu C, Liu Y, Yan S, Zheng M
Life sciences 2021 Nov 15;285:119918
Life sciences 2021 Nov 15;285:119918
Effects of Chronic Secondhand Smoke (SHS) Exposure on Cognitive Performance and Metabolic Pathways in the Hippocampus of Wild-Type and Human Tau Mice.
Raber J, Perez R, Torres ERS, Krenik D, Boutros S, Patel E, Chlebowski AC, Torres ER, Perveen Z, Penn A, Paulsen DB, Bartlett MG, Jia E, Holden S, Hall R, Morré J, Wong C, Ho E, Choi J, Stevens JF, Noël A, Bobe G, Kisby G
Environmental health perspectives 2021 May;129(5):57009
Environmental health perspectives 2021 May;129(5):57009
Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.
Li H, Dun Y, Zhang W, You B, Liu Y, Fu S, Qiu L, Cheng J, Ripley-Gonzalez JW, Liu S
Life sciences 2021 May 15;273:119314
Life sciences 2021 May 15;273:119314
Aptamer-SH2 superbinder-based targeted therapy for pancreatic ductal adenocarcinoma.
Liu AD, Zhou J, Bi XY, Hou GQ, Li SS, Chen Q, Xu H, Cao X
Clinical and translational medicine 2021 Mar;11(3):e337
Clinical and translational medicine 2021 Mar;11(3):e337
A maternal high-fat/low-fiber diet impairs glucose tolerance and induces the formation of glycolytic muscle fibers in neonatal offspring.
Hu C, Yang Y, Chen M, Hao X, Wang S, Yang L, Yin Y, Tan C
European journal of nutrition 2021 Aug;60(5):2709-2718
European journal of nutrition 2021 Aug;60(5):2709-2718
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Zhu Y, Yang H, Deng J, Fan D
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8428-8439
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8428-8439
CEBPG promotes esophageal squamous cell carcinoma progression by enhancing PI3K-AKT signaling.
Huang Y, Lin L, Shen Z, Li Y, Cao H, Peng L, Qiu Y, Cheng X, Meng M, Lu D, Yin D
American journal of cancer research 2020;10(10):3328-3344
American journal of cancer research 2020;10(10):3328-3344
miR-203 inhibits cell proliferation and ERK pathway in prostate cancer by targeting IRS-1.
Meng Y, Hu X, Li S, Zeng X, Qiu L, Wei M, Wang Z, Han J
BMC cancer 2020 Oct 27;20(1):1028
BMC cancer 2020 Oct 27;20(1):1028
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
Zhang H, Hui J, Yang J, Deng J, Fan D
European journal of pharmacology 2020 Nov 15;887:173557
European journal of pharmacology 2020 Nov 15;887:173557
Prenatal High-Salt Diet-Induced Metabolic Disorders via Decreasing Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α in Adult Male Rat Offspring.
Liu Y, Yang C, Feng X, Qi L, Guo J, Zhu D, Thai PN, Zhang Y, Zhang P, Sun M, Lv J, Zhang L, Xu Z, Lu X
Molecular nutrition & food research 2020 Jul;64(14):e2000196
Molecular nutrition & food research 2020 Jul;64(14):e2000196
Hydroxychloroquine Improves Obesity-Associated Insulin Resistance and Hepatic Steatosis by Regulating Lipid Metabolism.
Qiao X, Zhou ZC, Niu R, Su YT, Sun Y, Liu HL, Teng JL, Ye JN, Shi H, Yang CD, Cheng XB
Frontiers in pharmacology 2019;10:855
Frontiers in pharmacology 2019;10:855
Suppression of miR-143 contributes to overexpression of IL-6, HIF-1α and NF-κB p65 in Cr(VI)-induced human exposure and tumor growth.
Wang L, Qiu JG, He J, Liu WJ, Ge X, Zhou FM, Huang YX, Jiang BH, Liu LZ
Toxicology and applied pharmacology 2019 Sep 1;378:114603
Toxicology and applied pharmacology 2019 Sep 1;378:114603
Therapeutic potential of NaoXinTong Capsule on the developed diabetic nephropathy in db/db mice.
Yang S, Chen Y, Duan Y, Ma C, Liu L, Li Q, Yang J, Li X, Zhao B, Wang Y, Qian K, Liu M, Zhu Y, Yang X, Han J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109389
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109389
Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.
Wang F, Chang C, Li R, Zhang Z, Jiang H, Zeng N, Li D, Chen L, Xiao Y, Chen W, Wang Q
Toxicology 2019 Aug 1;424:152236
Toxicology 2019 Aug 1;424:152236
Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala.
Liang H, Mokrani A, Chisomo-Kasiya H, Ji K, Ge X, Ren M, Liu B, Xi B, Sun A
Fish physiology and biochemistry 2019 Apr;45(2):719-732
Fish physiology and biochemistry 2019 Apr;45(2):719-732
DJ-1 Deficiency Protects Hepatic Steatosis by Enhancing Fatty Acid Oxidation in Mice.
Xu M, Wu H, Li M, Wen Y, Yu C, Xia L, Xia Q, Kong X
International journal of biological sciences 2018;14(13):1892-1900
International journal of biological sciences 2018;14(13):1892-1900
miR-146b Inhibits Glucose Consumption by Targeting IRS1 Gene in Porcine Primary Adipocytes.
Zhu YL, Chen T, Xiong JL, Wu D, Xi QY, Luo JY, Sun JJ, Zhang YL
International journal of molecular sciences 2018 Mar 9;19(3)
International journal of molecular sciences 2018 Mar 9;19(3)
NaoXinTong Capsules inhibit the development of diabetic nephropathy in db/db mice.
Yang S, Liu M, Chen Y, Ma C, Liu L, Zhao B, Wang Y, Li X, Zhu Y, Gao X, Kong D, Duan Y, Han J, Yang X
Scientific reports 2018 Jun 14;8(1):9158
Scientific reports 2018 Jun 14;8(1):9158
Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy.
Wei W, An XR, Jin SJ, Li XX, Xu M
Scientific reports 2018 Jan 8;8(1):9
Scientific reports 2018 Jan 8;8(1):9
Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy.
Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li X, Han J, Duan Y
Scientific reports 2015 Jun 10;5:11219
Scientific reports 2015 Jun 10;5:11219
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A549 cells were subjected to SDS PAGE followed by western blot with 17509-1-AP(IRS1 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-IRS1 (IP:17509-1-AP, 5ug; Detection:17509-1-AP 1:1000) with A549 cells lysate 3500ug.
- Sample type
- cell line
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IRS1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IRS1. This antibody recognizes human antigen. The IRS1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 17509-1-AP(IRS1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
