FNab05134

antibody from FineTest Biotech
Targeting: MET DFNB97, HGFR, RCCP2
Provider product page for FNab05134
Western blot
ELISA
Immunoprecipitation
Immunohistochemistry

Antibody data

Product number
FNab05134 - Provider product page
Provider
FineTest Biotech
Product name
MET antibody
Antibody type
Polyclonal
Antigen
Recombinant protein fragment
Description
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis(By similarity). Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
met proto-oncogene(hepatocyte growt
h factor receptor)
Epitope
IgG
Isotype
IgG
Vial size
100¦Ìg
Concentration
Immunogen affinity purified
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
MET protein structure - FNab05134 shown in red.