CABT-B9225

antibody from Creative Diagnostics

Targeting: CDKN3 CDI1, KAP

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B9225

Provider

Creative Diagnostics

Product name

Mouse anti-Human KAP monoclonal antibody, clone 40/LBQ

Antibody type

Monoclonal

Description

Proteins that associate with cyclin-dependent kinases may function in cell cycle regulation. Therefore, a two-hybrid screen system was used to isolate cDNA which encode proteins that can interact with Cdk2. One of these was the dual-specificity protein phosphatase known as KAP (Cdk associated phosphatase). KAP contains the HCXXXXGR motif characteristic of protein tyrosine phosphatases. It utilizes substrates that contain either phosphotyrosine or phosphoserine residues. In addition to binding Cdk2, KAP also associates with Cdc2. KAP does not require a cyclin subunit for binding to Cdk2 and Cdc2. The association of KAP with these two Cdks suggests that KAP may play a role in cell cycle control, possibly by regulating the phosphorylation status of a cdk or of a Cdk-associated protein.

Reactivity

Human, Mouse, Rat, Canine, Chicken/Avian

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

40/LBQ

Vial size

50 _g

Concentration

250 Ã×g/ml

Storage

Store undiluted at -20°C.