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- References [25]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 55114-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#55114-1-AP, RRID:AB_10858393
- Product name
- NOTCH3 antibody
- Antibody type
- Polyclonal
- Description
- NOTCH3 antibody (Cat. #55114-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references UBE3A activates the NOTCH pathway and promotes esophageal cancer progression by degradation of ZNF185.
Elabela gene therapy promotes angiogenesis after myocardial infarction.
GALNT2 promotes cell proliferation, migration, and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma.
Selective Targeting of Class I Histone Deacetylases in a Model of Human Osteosarcoma.
Notch1 haploinsufficiency in mice accelerates adipogenesis.
Notch3 Modulates Cardiac Fibroblast Proliferation, Apoptosis, and Fibroblast to Myofibroblast Transition via Negative Regulation of the RhoA/ROCK/Hif1α Axis.
The effect of Notch signal pathway on PM2.5-induced Muc5ac in Beas-2B cells.
Overexpression of AMPD2 indicates poor prognosis in colorectal cancer patients via the Notch3 signaling pathway.
Circ_PUM1 promotes the development of endometrial cancer by targeting the miR-136/NOTCH3 pathway.
Upregulated MMP28 in Hepatocellular Carcinoma Promotes Metastasis via Notch3 Signaling and Predicts Unfavorable Prognosis.
Exosomal Notch3 from high glucose-stimulated endothelial cells regulates vascular smooth muscle cells calcification/aging.
DLL3 regulates the migration and invasion of small cell lung cancer by modulating Snail.
Downregulation of Notch Signaling in Kras-Induced Gastric Metaplasia.
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Laminin-521 promotes quiescence in isolated stellate cells from rat liver.
Mild hypothermia inhibits the Notch 3 and Notch 4 activation and seizure after stroke in the rat model.
Notch signaling via regulation of RB and p-AKT but not PIK3CG contributes to MIA PaCa-2 cell growth and migration to affect pancreatic carcinogenesis.
KrasG12D upregulates Notch signaling to induce gallbladder tumorigenesis in mice.
Lunatic Fringe and p53 Cooperatively Suppress Mesenchymal Stem-Like Breast Cancer.
Combined Methylome and Transcriptome Analysis During Rat Hepatic Stellate Cell Activation.
Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer.
Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction.
Neuropathological and biochemical assessments of an Alzheimer's disease patient treated with the γ-secretase inhibitor semagacestat.
Targeting Met and Notch in the Lfng-deficient, Met-amplified triple-negative breast cancer.
Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation.
Zheng Z, Zhang B, Yu H, Li S, Song N, Jin X, Li J
International journal of biological sciences 2021;17(12):3024-3035
International journal of biological sciences 2021;17(12):3024-3035
Elabela gene therapy promotes angiogenesis after myocardial infarction.
Jin L, Pan Y, Li Q, Li J, Wang Z
Journal of cellular and molecular medicine 2021 Sep;25(17):8537-8545
Journal of cellular and molecular medicine 2021 Sep;25(17):8537-8545
GALNT2 promotes cell proliferation, migration, and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma.
Wang W, Sun R, Zeng L, Chen Y, Zhang N, Cao S, Deng S, Meng X, Yang S
Life sciences 2021 Jul 1;276:119439
Life sciences 2021 Jul 1;276:119439
Selective Targeting of Class I Histone Deacetylases in a Model of Human Osteosarcoma.
Torres HM, VanCleave AM, Vollmer M, Callahan DL, Smithback A, Conn JM, Rodezno-Antunes T, Gao Z, Cao Y, Afeworki Y, Tao J
Cancers 2021 Aug 20;13(16)
Cancers 2021 Aug 20;13(16)
Notch1 haploinsufficiency in mice accelerates adipogenesis.
Yamaguchi K, Hayashi M, Uchida Y, Cheng XW, Nakayama T, Matsushita T, Murohara T, Takeshita K
Scientific reports 2021 Aug 18;11(1):16761
Scientific reports 2021 Aug 18;11(1):16761
Notch3 Modulates Cardiac Fibroblast Proliferation, Apoptosis, and Fibroblast to Myofibroblast Transition via Negative Regulation of the RhoA/ROCK/Hif1α Axis.
Shi J, Xiao P, Liu X, Chen Y, Xu Y, Fan J, Yin Y
Frontiers in physiology 2020;11:669
Frontiers in physiology 2020;11:669
The effect of Notch signal pathway on PM2.5-induced Muc5ac in Beas-2B cells.
Liu Y, Zhou T, Sun L, Wang H, Zhou L
Ecotoxicology and environmental safety 2020 Oct 15;203:110956
Ecotoxicology and environmental safety 2020 Oct 15;203:110956
Overexpression of AMPD2 indicates poor prognosis in colorectal cancer patients via the Notch3 signaling pathway.
Gao QZ, Qin Y, Wang WJ, Fei BJ, Han WF, Jin JQ, Gao X
World journal of clinical cases 2020 Aug 6;8(15):3197-3208
World journal of clinical cases 2020 Aug 6;8(15):3197-3208
Circ_PUM1 promotes the development of endometrial cancer by targeting the miR-136/NOTCH3 pathway.
Zong ZH, Liu Y, Chen S, Zhao Y
Journal of cellular and molecular medicine 2020 Apr;24(7):4127-4135
Journal of cellular and molecular medicine 2020 Apr;24(7):4127-4135
Upregulated MMP28 in Hepatocellular Carcinoma Promotes Metastasis via Notch3 Signaling and Predicts Unfavorable Prognosis.
Zhou J, Zheng X, Feng M, Mo Z, Shan Y, Wang Y, Jin J
International journal of biological sciences 2019;15(4):812-825
International journal of biological sciences 2019;15(4):812-825
Exosomal Notch3 from high glucose-stimulated endothelial cells regulates vascular smooth muscle cells calcification/aging.
Lin X, Li S, Wang YJ, Wang Y, Zhong JY, He JY, Cui XJ, Zhan JK, Liu YS
Life sciences 2019 Sep 1;232:116582
Life sciences 2019 Sep 1;232:116582
DLL3 regulates the migration and invasion of small cell lung cancer by modulating Snail.
Furuta M, Kikuchi H, Shoji T, Takashima Y, Kikuchi E, Kikuchi J, Kinoshita I, Dosaka-Akita H, Sakakibara-Konishi J
Cancer science 2019 May;110(5):1599-1608
Cancer science 2019 May;110(5):1599-1608
Downregulation of Notch Signaling in Kras-Induced Gastric Metaplasia.
Chung WC, Zhou Y, Atfi A, Xu K
Neoplasia (New York, N.Y.) 2019 Aug;21(8):810-821
Neoplasia (New York, N.Y.) 2019 Aug;21(8):810-821
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Zhong X, Cui P, Cai Y, Wang L, He X, Long P, Lu K, Yan R, Zhang Y, Pan X, Zhao X, Li W, Zhang H, Zhou Q, Gao P
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Laminin-521 promotes quiescence in isolated stellate cells from rat liver.
Rohn F, Kordes C, Castoldi M, Götze S, Poschmann G, Stühler K, Herebian D, Benk AS, Geiger F, Zhang T, Spatz JP, Häussinger D
Biomaterials 2018 Oct;180:36-51
Biomaterials 2018 Oct;180:36-51
Mild hypothermia inhibits the Notch 3 and Notch 4 activation and seizure after stroke in the rat model.
Yang GS, Zhou XY, An XF, Liu XJ, Zhang YJ, Yu D
Pathology, research and practice 2018 Jul;214(7):1008-1016
Pathology, research and practice 2018 Jul;214(7):1008-1016
Notch signaling via regulation of RB and p-AKT but not PIK3CG contributes to MIA PaCa-2 cell growth and migration to affect pancreatic carcinogenesis.
Zhang S, Liu J, Xu K, Li Z
Oncology letters 2018 Feb;15(2):2105-2110
Oncology letters 2018 Feb;15(2):2105-2110
KrasG12D upregulates Notch signaling to induce gallbladder tumorigenesis in mice.
Chung WC, Wang J, Zhou Y, Xu K
Oncoscience 2017 Sep;4(9-10):131-138
Oncoscience 2017 Sep;4(9-10):131-138
Lunatic Fringe and p53 Cooperatively Suppress Mesenchymal Stem-Like Breast Cancer.
Chung WC, Zhang S, Challagundla L, Zhou Y, Xu K
Neoplasia (New York, N.Y.) 2017 Nov;19(11):885-895
Neoplasia (New York, N.Y.) 2017 Nov;19(11):885-895
Combined Methylome and Transcriptome Analysis During Rat Hepatic Stellate Cell Activation.
Schumacher EC, Götze S, Kordes C, Benes V, Häussinger D
Stem cells and development 2017 Dec 15;26(24):1759-1770
Stem cells and development 2017 Dec 15;26(24):1759-1770
Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer.
Zhang S, Chung WC, Xu K
Oncogene 2016 May 12;35(19):2485-95
Oncogene 2016 May 12;35(19):2485-95
Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction.
Zhang S, Chung WC, Wu G, Egan SE, Miele L, Xu K
Cancer research 2015 May 15;75(10):1936-43
Cancer research 2015 May 15;75(10):1936-43
Neuropathological and biochemical assessments of an Alzheimer's disease patient treated with the γ-secretase inhibitor semagacestat.
Roher AE, Maarouf CL, Kokjohn TA, Whiteside CM, Kalback WM, Serrano G, Belden C, Liebsack C, Jacobson SA, Sabbagh MN, Beach TG
American journal of neurodegenerative disease 2014;3(3):115-33
American journal of neurodegenerative disease 2014;3(3):115-33
Targeting Met and Notch in the Lfng-deficient, Met-amplified triple-negative breast cancer.
Zhang S, Chung WC, Miele L, Xu K
Cancer biology & therapy 2014 May;15(5):633-42
Cancer biology & therapy 2014 May;15(5):633-42
Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation.
Zhang S, Chung WC, Wu G, Egan SE, Xu K
Neoplasia (New York, N.Y.) 2014 Feb;16(2):158-67
Neoplasia (New York, N.Y.) 2014 Feb;16(2):158-67
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- COLO 320 cells were subjected to SDS PAGE followed by western blot with 55114-1-AP(NOTCH3 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 55114-1-AP(NOTCH3 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NOTCH3 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human NOTCH3. This antibody recognizes human, mouse, rat antigen. The NOTCH3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
