345405

antibody from BioLegend
Targeting: NOTCH3 CADASIL, CASIL
Provider product page for 345405

Antibody data

Product number
345405 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#345405, RRID:AB_2151232
Product name
PE anti-human Notch 3
Antibody type
Monoclonal
Antigen
Human Notch 3-human IgG1 Fc fusion protein
Description
The Notch receptors are highly conserved from invertebrates to mammals. While Notch 1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences. The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus. This translocation triggers a series of signaling processes. Notch 3 is primarily expressed in adult arterial smooth muscle cells. Notch3 gene mutation can cause CADASIL, a hereditary early stroke syndrome.
Reactivity
Human
Host
Mouse
Conjugate
Yellow dye
Isotype
IgG
Vial size
25 tests
Storage
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
NOTCH3 protein structure - 345405 shown in red.