Antibody data

Product number
648902 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#648902, RRID:AB_2250906
Product name
Purified anti-MyD88
Antibody type
Polyclonal
Antigen
Synthetic peptide (c-terminus)
Description
MyD88, originally isolated as myeloid differentiation primary response gene, is expressed in a variety of tissues.  MyD88 serves as a cytoplasmic adaptor protein involved in the signaling of TLR and IL-1R family members.  It associates with and recruits IRAK to IL-1R complex in response to IL-1. This pathway leads to activation of NF-kB. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL-1 and IL-18. MyD88 deficient mice lack a response to LPS (a bacterial product) which employs toll like receptors 2 and 4 (TLR2 and TLR4) as signaling receptors.
Reactivity
Human, Mouse
Host
Rabbit
Conjugate
Unconjugated
Vial size
100 µl
Storage
The antibody solution should be stored undiluted at -20°C.
MYD88 protein structure - 648902 shown in red.