18409-1-AP
antibody from Proteintech Group
Targeting: TOMM40
C19orf1, D19S1177E, PER-EC1, PEREC1, TOM40
Antibody data
- Antibody Data
- Antigen structure
- References [38]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 18409-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18409-1-AP, RRID:AB_2303725
- Product name
- TOMM40 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TOMM40 antibody (Cat. #18409-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Serine palmitoyltransferase assembles at ER-mitochondria contact sites.
Homeostatic control of nuclear-encoded mitochondrial gene expression by the histone variant H2A.Z is essential for neuronal survival.
Longitudinal single-cell analysis of a myeloma mouse model identifies subclonal molecular programs associated with progression.
VPS13D bridges the ER to mitochondria and peroxisomes via Miro.
Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation.
Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination.
High-throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts.
Pharmacological inhibition of USP30 activates tissue-specific mitophagy.
Modulation of OSCP mitigates mitochondrial and synaptic deficits in a mouse model of Alzheimer's pathology.
Differential mitochondrial proteomic analysis of A549 cells infected with avian influenza virus subtypes H5 and H9.
Mitochondrial copper and phosphate transporter specificity was defined early in the evolution of eukaryotes.
Identification and detection of mecciRNAs.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility.
HPDL deficiency causes a neuromuscular disease by impairing the mitochondrial respiration.
Long-term exposure to environmental level of phenanthrene causes adaptive immune response and fibrosis in mouse kidneys.
Dependence of PINK1 accumulation on mitochondrial redox system.
Mitochondrial dysfunction caused by novel ATAD3A mutations.
Identification of mecciRNAs and their roles in the mitochondrial entry of proteins.
Distal control of mitochondrial biogenesis and respiratory activity by extracellular lactate caused by large-scale deletion of mitochondrial DNA.
TOM40 Inhibits Ovarian Cancer Cell Growth by Modulating Mitochondrial Function Including Intracellular ATP and ROS Levels.
Mutations in TOMM70 lead to multi-OXPHOS deficiencies and cause severe anemia, lactic acidosis, and developmental delay.
Dynamic Regulation of Mitochondrial Import by the Ubiquitin System.
Cyclophilin D counterbalances mitochondrial calcium uniporter-mediated brain mitochondrial calcium uptake.
Radiation induces apoptosis primarily through the intrinsic pathway in mammalian cells.
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer.
The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.
Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice.
Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1.
Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement.
The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα.
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
A Novel Non-Apoptotic Role of Procaspase-3 in the Regulation of Mitochondrial Biogenesis Activators.
Changes in the mitochondrial proteome in human hepatocytes in response to alpha-amanitin hepatotoxicity.
Novel insights into SLC25A46-related pathologies in a genetic mouse model.
The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity.
Cytosolic PINK1 promotes the targeting of ubiquitinated proteins to the aggresome-autophagy pathway during proteasomal stress.
Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure.
Aaltonen MJ, Alecu I, König T, Bennett SA, Shoubridge EA
Life science alliance 2022 Feb;5(2)
Life science alliance 2022 Feb;5(2)
Homeostatic control of nuclear-encoded mitochondrial gene expression by the histone variant H2A.Z is essential for neuronal survival.
Lowden C, Boulet A, Boehler NA, Seecharran S, Rios Garcia J, Lowe NJ, Liu J, Ong JLK, Wang W, Ma L, Cheng AH, Senatore A, Monks DA, Liu BH, Leary SC, Cheng HM
Cell reports 2021 Sep 14;36(11):109704
Cell reports 2021 Sep 14;36(11):109704
Longitudinal single-cell analysis of a myeloma mouse model identifies subclonal molecular programs associated with progression.
Croucher DC, Richards LM, Tsofack SP, Waller D, Li Z, Wei EN, Huang XF, Chesi M, Bergsagel PL, Sebag M, Pugh TJ, Trudel S
Nature communications 2021 Nov 3;12(1):6322
Nature communications 2021 Nov 3;12(1):6322
VPS13D bridges the ER to mitochondria and peroxisomes via Miro.
Guillén-Samander A, Leonzino M, Hanna MG, Tang N, Shen H, De Camilli P
The Journal of cell biology 2021 May 3;220(5)
The Journal of cell biology 2021 May 3;220(5)
Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation.
Yang W, Pang D, Chen M, Du C, Jia L, Wang L, He Y, Jiang W, Luo L, Yu Z, Mao M, Yuan Q, Tang P, Xia X, Cui Y, Jing B, Platero A, Liu Y, Wei Y, Worley PF, Xiao B
Developmental cell 2021 Mar 22;56(6):811-825.e6
Developmental cell 2021 Mar 22;56(6):811-825.e6
Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination.
Oshima Y, Cartier E, Boyman L, Verhoeven N, Polster BM, Huang W, Kane M, Lederer WJ, Karbowski M
The Journal of cell biology 2021 Jun 7;220(6)
The Journal of cell biology 2021 Jun 7;220(6)
High-throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts.
Cretin E, Lopes P, Vimont E, Tatsuta T, Langer T, Gazi A, Sachse M, Yu-Wai-Man P, Reynier P, Wai T
EMBO molecular medicine 2021 Jun 7;13(6):e13579
EMBO molecular medicine 2021 Jun 7;13(6):e13579
Pharmacological inhibition of USP30 activates tissue-specific mitophagy.
Luo H, Krigman J, Zhang R, Yang M, Sun N
Acta physiologica (Oxford, England) 2021 Jul;232(3):e13666
Acta physiologica (Oxford, England) 2021 Jul;232(3):e13666
Modulation of OSCP mitigates mitochondrial and synaptic deficits in a mouse model of Alzheimer's pathology.
Gauba E, Sui S, Tian J, Driskill C, Jia K, Yu C, Rughwani T, Wang Q, Kroener S, Guo L, Du H
Neurobiology of aging 2021 Feb;98:63-77
Neurobiology of aging 2021 Feb;98:63-77
Differential mitochondrial proteomic analysis of A549 cells infected with avian influenza virus subtypes H5 and H9.
Yang Y, Zhang Y, Yang C, Fang F, Wang Y, Chang H, Chen Z, Chen P
Virology journal 2021 Feb 18;18(1):39
Virology journal 2021 Feb 18;18(1):39
Mitochondrial copper and phosphate transporter specificity was defined early in the evolution of eukaryotes.
Zhu X, Boulet A, Buckley KM, Phillips CB, Gammon MG, Oldfather LE, Moore SA, Leary SC, Cobine PA
eLife 2021 Feb 16;10
eLife 2021 Feb 16;10
Identification and detection of mecciRNAs.
Liu X, Yang Y, Shan G
Methods (San Diego, Calif.) 2021 Dec;196:147-152
Methods (San Diego, Calif.) 2021 Dec;196:147-152
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Morgenstern M, Peikert CD, Lübbert P, Suppanz I, Klemm C, Alka O, Steiert C, Naumenko N, Schendzielorz A, Melchionda L, Mühlhäuser WWD, Knapp B, Busch JD, Stiller SB, Dannenmaier S, Lindau C, Licheva M, Eickhorst C, Galbusera R, Zerbes RM, Ryan MT, Kraft C, Kozjak-Pavlovic V, Drepper F, Dennerlein S, Oeljeklaus S, Pfanner N, Wiedemann N, Warscheid B
Cell metabolism 2021 Dec 7;33(12):2464-2483.e18
Cell metabolism 2021 Dec 7;33(12):2464-2483.e18
Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility.
Lei Y, Zhang X, Xu Q, Liu S, Li C, Jiang H, Lin H, Kong E, Liu J, Qi S, Li H, Xu W, Lu K
Developmental cell 2021 Aug 23;56(16):2313-2328.e7
Developmental cell 2021 Aug 23;56(16):2313-2328.e7
HPDL deficiency causes a neuromuscular disease by impairing the mitochondrial respiration.
Sun Y, Wei X, Fang F, Shen Y, Wei H, Li J, Ye X, Zhan Y, Ye X, Liu X, Yang W, Li Y, Geng X, Huang X, Ruan Y, Qin Z, Yi S, Lyu J, Fang H, Yu Y
Journal of genetics and genomics = Yi chuan xue bao 2021 Aug 20;48(8):727-736
Journal of genetics and genomics = Yi chuan xue bao 2021 Aug 20;48(8):727-736
Long-term exposure to environmental level of phenanthrene causes adaptive immune response and fibrosis in mouse kidneys.
Ruan F, Wu L, Yin H, Fang L, Tang C, Huang S, Fang L, Zuo Z, He C, Huang J
Environmental pollution (Barking, Essex : 1987) 2021 Aug 15;283:117028
Environmental pollution (Barking, Essex : 1987) 2021 Aug 15;283:117028
Dependence of PINK1 accumulation on mitochondrial redox system.
Gao F, Zhang Y, Hou X, Tao Z, Ren H, Wang G
Aging cell 2020 Sep;19(9):e13211
Aging cell 2020 Sep;19(9):e13211
Mitochondrial dysfunction caused by novel ATAD3A mutations.
Dorison N, Gaignard P, Bayot A, Gelot A, Becker PH, Fourati S, Lebigot E, Charles P, Wai T, Therond P, Slama A
Molecular genetics and metabolism 2020 Sep - Oct;131(1-2):107-113
Molecular genetics and metabolism 2020 Sep - Oct;131(1-2):107-113
Identification of mecciRNAs and their roles in the mitochondrial entry of proteins.
Liu X, Wang X, Li J, Hu S, Deng Y, Yin H, Bao X, Zhang QC, Wang G, Wang B, Shi Q, Shan G
Science China. Life sciences 2020 Oct;63(10):1429-1449
Science China. Life sciences 2020 Oct;63(10):1429-1449
Distal control of mitochondrial biogenesis and respiratory activity by extracellular lactate caused by large-scale deletion of mitochondrial DNA.
Ogasawara E, Nakada K, Ishihara N
Pharmacological research 2020 Oct;160:105204
Pharmacological research 2020 Oct;160:105204
TOM40 Inhibits Ovarian Cancer Cell Growth by Modulating Mitochondrial Function Including Intracellular ATP and ROS Levels.
Yang W, Shin HY, Cho H, Chung JY, Lee EJ, Kim JH, Kang ES
Cancers 2020 May 22;12(5)
Cancers 2020 May 22;12(5)
Mutations in TOMM70 lead to multi-OXPHOS deficiencies and cause severe anemia, lactic acidosis, and developmental delay.
Wei X, Du M, Xie J, Luo T, Zhou Y, Zhang K, Li J, Chen D, Xu P, Jia M, Zhou H, Fang H, Lyu J, Yang Y
Journal of human genetics 2020 Mar;65(3):231-240
Journal of human genetics 2020 Mar;65(3):231-240
Dynamic Regulation of Mitochondrial Import by the Ubiquitin System.
Phu L, Rose CM, Tea JS, Wall CE, Verschueren E, Cheung TK, Kirkpatrick DS, Bingol B
Molecular cell 2020 Mar 5;77(5):1107-1123.e10
Molecular cell 2020 Mar 5;77(5):1107-1123.e10
Cyclophilin D counterbalances mitochondrial calcium uniporter-mediated brain mitochondrial calcium uptake.
Zhang B, Jia K, Tian J, Du H
Biochemical and biophysical research communications 2020 Aug 20;529(2):314-320
Biochemical and biophysical research communications 2020 Aug 20;529(2):314-320
Radiation induces apoptosis primarily through the intrinsic pathway in mammalian cells.
Cao X, Wen P, Fu Y, Gao Y, Qi X, Chen B, Tao Y, Wu L, Xu A, Lu H, Zhao G
Cellular signalling 2019 Oct;62:109337
Cellular signalling 2019 Oct;62:109337
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer.
Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB
Nature 2019 Nov;575(7782):380-384
Nature 2019 Nov;575(7782):380-384
The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.
Hoshino A, Wang WJ, Wada S, McDermott-Roe C, Evans CS, Gosis B, Morley MP, Rathi KS, Li J, Li K, Yang S, McManus MJ, Bowman C, Potluri P, Levin M, Damrauer S, Wallace DC, Holzbaur ELF, Arany Z
Nature 2019 Nov;575(7782):375-379
Nature 2019 Nov;575(7782):375-379
Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice.
Violitzi F, Perivolidi VI, Thireou T, Grivas I, Haralambous S, Samiotaki M, Panayotou G, Douni E
Journal of proteome research 2019 Nov 1;18(11):3896-3912
Journal of proteome research 2019 Nov 1;18(11):3896-3912
Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1.
Sekine S, Wang C, Sideris DP, Bunker E, Zhang Z, Youle RJ
Molecular cell 2019 Mar 7;73(5):1028-1043.e5
Molecular cell 2019 Mar 7;73(5):1028-1043.e5
Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement.
Wang Q, Tian J, Chen H, Du H, Guo L
Neurobiology of disease 2019 Jul;127:410-418
Neurobiology of disease 2019 Jul;127:410-418
The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα.
Iershov A, Nemazanyy I, Alkhoury C, Girard M, Barth E, Cagnard N, Montagner A, Chretien D, Rugarli EI, Guillou H, Pende M, Panasyuk G
Nature communications 2019 Apr 5;10(1):1566
Nature communications 2019 Apr 5;10(1):1566
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
Jian F, Chen D, Chen L, Yan C, Lu B, Zhu Y, Chen S, Shi A, Chan DC, Song Z
Cell reports 2018 Jun 5;23(10):2989-3005
Cell reports 2018 Jun 5;23(10):2989-3005
A Novel Non-Apoptotic Role of Procaspase-3 in the Regulation of Mitochondrial Biogenesis Activators.
Kim JS, Ha JY, Yang SJ, Son JH
Journal of cellular biochemistry 2018 Jan;119(1):347-357
Journal of cellular biochemistry 2018 Jan;119(1):347-357
Changes in the mitochondrial proteome in human hepatocytes in response to alpha-amanitin hepatotoxicity.
Wang M, Chen Y, Guo Z, Yang C, Qi J, Fu Y, Chen Z, Chen P, Wang Y
Toxicon : official journal of the International Society on Toxinology 2018 Dec 15;156:34-40
Toxicon : official journal of the International Society on Toxinology 2018 Dec 15;156:34-40
Novel insights into SLC25A46-related pathologies in a genetic mouse model.
Terzenidou ME, Segklia A, Kano T, Papastefanaki F, Karakostas A, Charalambous M, Ioakeimidis F, Papadaki M, Kloukina I, Chrysanthou-Piterou M, Samiotaki M, Panayotou G, Matsas R, Douni E
PLoS genetics 2017 Apr;13(4):e1006656
PLoS genetics 2017 Apr;13(4):e1006656
The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity.
Ando M, Fiesel FC, Hudec R, Caulfield TR, Ogaki K, Górka-Skoczylas P, Koziorowski D, Friedman A, Chen L, Dawson VL, Dawson TM, Bu G, Ross OA, Wszolek ZK, Springer W
Molecular neurodegeneration 2017 Apr 24;12(1):32
Molecular neurodegeneration 2017 Apr 24;12(1):32
Cytosolic PINK1 promotes the targeting of ubiquitinated proteins to the aggresome-autophagy pathway during proteasomal stress.
Gao J, Li M, Qin S, Zhang T, Jiang S, Hu Y, Deng Y, Zhang C, You D, Li H, Mu D, Zhang Z, Jiang C
Autophagy 2016;12(4):632-47
Autophagy 2016;12(4):632-47
Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure.
Ding C, Wu Z, Huang L, Wang Y, Xue J, Chen S, Deng Z, Wang L, Song Z, Chen S
Scientific reports 2015 Nov 4;5:16064
Scientific reports 2015 Nov 4;5:16064
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 18409-1-AP(TOMM40 antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Tom40 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Tom40. This antibody recognizes human,mouse,rat antigen. The Tom40 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human placenta using 18409-1-AP(TOMM40 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human placenta using 18409-1-AP(TOMM40 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue