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Learn11-7550
antibody from ABEOMICS Inc.
Targeting: SMARCB1
BAF47, hSNFS, Ini1, PPP1R144, RDT, Sfh1p, SNF5, SNF5L1, Snr1
Western blotAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- 11-7550 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-INI-1/SNF5 Antibody
- Antibody type
- Polyclonal
- Description
- SNF5/INI1 is the core subunit of the SWI/SNF chromatin remodeling complex that contributes to the regulation of chromatin structure. It is a tumor suppressor in humans and mice, with an essential role in early embryonic development. SNF5 interacts with UV damage recognition factor XPC and colocalizes at the damage site upon UV irradiation. Inactivation of SNF5 affects the recruitment of ATM checkpoint kinase to the damage site and ATM activation by phosphorylation. SNF5 deficiency results in a defect in H2AX and BRCA1 phosphorylation at the damage site. SNF5/INI1 forms a functional complex with p300/GATA4 on hypertrophic response gene promoters in cardiomyocytes. It plays an inhibitory role in cardiomyocyte hypertrophy by suppressing p300/GATA4-dependent transcription. SNF5 genetic mutations were first reported in malignant rhabdoid tumors.
- Reactivity
- Human
- Host
- Rabbit
- Antigen sequence
A partial length recombinant INI-1/
SNF5 protein (amino acids 11-231) w
as used as the immunogen for this a
ntibody.- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
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Supportive validation
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- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Expression analysis of INI-1/SNF5. Anti-INI-1/SNF5 antibody (11-7550) was used at 1 µg/ml on MCF-7 lysate.
