11-7550-25

antibody from ABEOMICS Inc.
Targeting: SMARCB1 BAF47, hSNFS, Ini1, PPP1R144, RDT, Sfh1p, SNF5, SNF5L1, Snr1
Provider product page for 11-7550-25

Antibody data

Product number
11-7550-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-INI-1/SNF5 Antibody
Antibody type
Polyclonal
Description
SNF5/INI1 is the core subunit of the SWI/SNF chromatin remodeling complex that contributes to the regulation of chromatin structure. It is a tumor suppressor in humans and mice, with an essential role in early embryonic development. SNF5 interacts with UV damage recognition factor XPC and colocalizes at the damage site upon UV irradiation. Inactivation of SNF5 affects the recruitment of ATM checkpoint kinase to the damage site and ATM activation by phosphorylation. SNF5 deficiency results in a defect in H2AX and BRCA1 phosphorylation at the damage site. SNF5/INI1 forms a functional complex with p300/GATA4 on hypertrophic response gene promoters in cardiomyocytes. It plays an inhibitory role in cardiomyocyte hypertrophy by suppressing p300/GATA4-dependent transcription. SNF5 genetic mutations were first reported in malignant rhabdoid tumors.
Reactivity
Human
Host
Rabbit
Antigen sequence
A partial length recombinant INI-1/
SNF5 protein (amino acids 11-231) w
as used as the immunogen for this a
ntibody.
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
SMARCB1 protein structure - 11-7550-25 shown in red.