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Western blot
ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Validations
- Immunoprecipitation [1]
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- Product number
- ABIN306916 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-TYRO Protein tyrosine Kinase Binding Protein (TYROBP) antibody
- Antibody type
- Polyclonal
- Antigen
- Other
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Vial size
- 100 µg
- Concentration
- 1 mg/ml
- Storage
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Submitted references DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk.
Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice.
DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming.
Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts.
DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase.
Zou W, Reeve JL, Liu Y, Teitelbaum SL, Ross FP
Molecular cell 2008 Aug 8;31(3):422-31
Molecular cell 2008 Aug 8;31(3):422-31
Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice.
Tomasello E, Desmoulins PO, Chemin K, Guia S, Cremer H, Ortaldo J, Love P, Kaiserlian D, Vivier E
Immunity 2000 Sep;13(3):355-64
Immunity 2000 Sep;13(3):355-64
DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming.
Bakker AB, Hoek RM, Cerwenka A, Blom B, Lucian L, McNeil T, Murray R, Phillips LH, Sedgwick JD, Lanier LL
Immunity 2000 Sep;13(3):345-53
Immunity 2000 Sep;13(3):345-53
Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts.
Paloneva J, Kestilä M, Wu J, Salminen A, Böhling T, Ruotsalainen V, Hakola P, Bakker AB, Phillips JH, Pekkarinen P, Lanier LL, Timonen T, Peltonen L
Nature genetics 2000 Jul;25(3):357-61
Nature genetics 2000 Jul;25(3):357-61
DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase.
McVicar DW, Taylor LS, Gosselin P, Willette-Brown J, Mikhael AI, Geahlen RL, Nakamura MC, Linnemeyer P, Seaman WE, Anderson SK, Ortaldo JR, Mason LH
The Journal of biological chemistry 1998 Dec 4;273(49):32934-42
The Journal of biological chemistry 1998 Dec 4;273(49):32934-42
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Immunoprecipitation using DAP12 antibody on MHC class I (1) and NKp44 (2) positive cells.
