Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- CABT-B9034 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Anti-IRE1Ï« polyclonal antibody
- Antibody type
- Polyclonal
- Description
- The gene ERN1 (endoplasmic reticulum to nucleus signaling 1) encodes an ER transmembrane kinase/endoribonuclease that is also referred to as IRE1ϫ (inositol-requiring transmembrane kinase and endonuclease 1ϫ). The serine-threonine protein kinase encoded by this gene is ubiquitously expressed in cells and tissues. It serves as an ER stress sensor that initiates the splicing of the mRNA encoding X-boxÿbinding protein 1 (XBP-1) upon activation. Spliced XBP-1 mRNA produces homeostatic transcription factor XBP1. Under ER stress, the RNase activity of IRE1ϫ cleaves many ER-localized mRNAs associated with apoptosis. The cytosolic motif of the activated form of IRE1ϫ associates with the adaptor protein TRAF2 (tumor necrosis factor (TNF)ÿassociated factor 2). This complex activates the c-Jun N-terminal kinase (JNK) signaling pathway.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Storage
- ?20°C
No comments: Submit comment
No validations: Submit validation data