11-7008-25

antibody from ABEOMICS Inc.
Targeting: FURIN FUR, PACE, PCSK3, SPC1
Provider product page for 11-7008-25

Antibody data

Product number
11-7008-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-Furin Antibody
Antibody type
Polyclonal
Description
Furin is a member of the PCs family (Pro-Hormone/Pro-Protein Convertase) of subtilisin-like endoproteinases. Furin along with PCs are intensively investigated as pharmacological targets for the treatment of many diseases, e.g., atherosclerosis, hypercholesterolaemia, and cancer, as well as viral and bacterial infections. Furin has been implicated in processing the Env (Envelope) proteins of human endogenous retroviruses, syncytins, the only possible fusogens known to be involved in placenta syncytialization, and therefore may participate in syncytin-mediated cell fusion in cells of both trophoblast and non-trophoblast lineages. Furin catalyzes proteolytic maturation of a diverse repertoire of growth factors, receptors, and enzyme precursors within multiple secretory pathway compartments. Proteolysis by furin is highly specific and occurs at C-terminal to a multibasic recognition motive. Furin is highly expressed in EVTs (Extravillous CTBs) and that furin function is required for trophoblast cell invasion into the maternal endometrium.
Reactivity
Human
Host
Rabbit
Antigen sequence
A partial length recombinant Furin
protein (amino acids 602-791) was u
sed as the immunogen for this antib
ody.
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
FURIN protein structure - 11-7008-25 shown in red.