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- Antigen structure
- References [25]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 25699-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- BDNF antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated BDNF antibody (Cat. #25699-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CPEB3-dowregulated Nr3c1 mRNA translation confers resilience to developing posttraumatic stress disorder-like behavior in fear-conditioned mice.
Young Blood Rescues the Cognition of Alzheimer's Model Mice by Restoring the Hippocampal Cholinergic Circuit.
Chaihu-Shugan-San and absorbed meranzin hydrate induce anti-atherosclerosis and behavioral improvements in high-fat diet ApoE-/- mice via anti-inflammatory and BDNF-TrkB pathway.
Aqueous extract from You-Gui-Yin ameliorates cognitive impairment of chronic renal failure mice through targeting hippocampal CaMKIIα/CREB/BDNF and EPO/EPOR pathways.
Chronic mild hypoxia promotes hippocampal neurogenesis involving Notch1 signaling in epileptic rats.
Ascorbic Acid Attenuates Lead-Induced Alterations in the Synapses in the Developing Rat Cerebellum.
Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway.
Effects of vortioxetine and fluoxetine on the level of Brain Derived Neurotrophic Factors (BDNF) in the hippocampus of chronic unpredictable mild stress-induced depressive rats.
Neuroprotective effect of 1-Deoxynojirimycin on cognitive impairment, β-amyloid deposition, and neuroinflammation in the SAMP8 mice.
Agomelatine-induced modulation of brain-derived neurotrophic factor (BDNF) in the rat hippocampus.
Furin promotes dendritic morphogenesis and learning and memory in transgenic mice.
miR-124 and miR-9 mediated downregulation of HDAC5 promotes neurite development through activating MEF2C-GPM6A pathway.
Long-term moderate exercise enhances specific proteins that constitute neurotrophin signaling pathway: A TMT-based quantitative proteomic analysis of rat plasma.
MR-guided delivery of AAV2-BDNF into the entorhinal cortex of non-human primates.
Astrocytes mediated the nootropic and neurotrophic effects of Sarsasapogenin-AA13 via upregulating brain-derived neurotrophic factor.
Danshen-Chuanxiong-Honghua Ameliorates Cerebral Impairment and Improves Spatial Cognitive Deficits after Transient Focal Ischemia and Identification of Active Compounds.
Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ1-42-Induced Rat Model of Alzheimer's Disease.
Total abdominal irradiation exposure impairs cognitive function involving miR-34a-5p/BDNF axis.
The Role of Endogenous Neurogenesis in Functional Recovery and Motor Map Reorganization Induced by Rehabilitative Therapy after Stroke in Rats.
Human Umbilical Cord Mesenchymal Stem Cells Overexpressing Nerve Growth Factor Ameliorate Diabetic Cystopathy in Rats.
Bone Marrow Stromal Cell Intraspinal Transplants Fail to Improve Motor Outcomes in a Severe Model of Spinal Cord Injury.
Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice.
SCM-198 Ameliorates Cognitive Deficits, Promotes Neuronal Survival and Enhances CREB/BDNF/TrkB Signaling without Affecting Aβ Burden in AβPP/PS1 Mice.
Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition.
Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice.
Lu WH, Chao HW, Lin PY, Lin SH, Liu TH, Chen HW, Huang YS
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2021 Aug;46(9):1669-1679
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2021 Aug;46(9):1669-1679
Young Blood Rescues the Cognition of Alzheimer's Model Mice by Restoring the Hippocampal Cholinergic Circuit.
Xia E, Xu F, Hu C, Kumal JPP, Tang X, Mao D, Li Y, Wu D, Zhang R, Wu S, Sun L
Neuroscience 2019 Oct 1;417:57-69
Neuroscience 2019 Oct 1;417:57-69
Chaihu-Shugan-San and absorbed meranzin hydrate induce anti-atherosclerosis and behavioral improvements in high-fat diet ApoE-/- mice via anti-inflammatory and BDNF-TrkB pathway.
Li L, Yu AL, Wang ZL, Chen K, Zheng W, Zhou JJ, Xie Q, Yan HB, Ren P, Huang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108893
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108893
Aqueous extract from You-Gui-Yin ameliorates cognitive impairment of chronic renal failure mice through targeting hippocampal CaMKIIα/CREB/BDNF and EPO/EPOR pathways.
Tang Q, Ke H, Wu C, Zeng J, Li Z, Liu Y, Feng S, Xue Q, Xu X
Journal of ethnopharmacology 2019 Jul 15;239:111925
Journal of ethnopharmacology 2019 Jul 15;239:111925
Chronic mild hypoxia promotes hippocampal neurogenesis involving Notch1 signaling in epileptic rats.
Sun C, Fu J, Qu Z, Li D, Si P, Qiao Q, Zhang W, Xue Y, Zhen J, Wang W
Brain research 2019 Jul 1;1714:88-98
Brain research 2019 Jul 1;1714:88-98
Ascorbic Acid Attenuates Lead-Induced Alterations in the Synapses in the Developing Rat Cerebellum.
Nam SM, Cho IS, Seo JS, Go TH, Kim JH, Nahm SS, Chang BJ, Lee JH
Biological trace element research 2019 Jan;187(1):142-150
Biological trace element research 2019 Jan;187(1):142-150
Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway.
Belviranlı M, Okudan N
Neuromolecular medicine 2018 Sep;20(3):386-400
Neuromolecular medicine 2018 Sep;20(3):386-400
Effects of vortioxetine and fluoxetine on the level of Brain Derived Neurotrophic Factors (BDNF) in the hippocampus of chronic unpredictable mild stress-induced depressive rats.
Lu Y, Ho CS, McIntyre RS, Wang W, Ho RC
Brain research bulletin 2018 Sep;142:1-7
Brain research bulletin 2018 Sep;142:1-7
Neuroprotective effect of 1-Deoxynojirimycin on cognitive impairment, β-amyloid deposition, and neuroinflammation in the SAMP8 mice.
Chen W, Liang T, Zuo W, Wu X, Shen Z, Wang F, Li C, Zheng Y, Peng G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:92-97
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:92-97
Agomelatine-induced modulation of brain-derived neurotrophic factor (BDNF) in the rat hippocampus.
Lu Y, Ho CS, McIntyre RS, Wang W, Ho RC
Life sciences 2018 Oct 1;210:177-184
Life sciences 2018 Oct 1;210:177-184
Furin promotes dendritic morphogenesis and learning and memory in transgenic mice.
Zhu B, Zhao L, Luo D, Xu D, Tan T, Dong Z, Tang Y, Min Z, Deng X, Sun F, Yan Z, Chen G
Cellular and molecular life sciences : CMLS 2018 Jul;75(13):2473-2488
Cellular and molecular life sciences : CMLS 2018 Jul;75(13):2473-2488
miR-124 and miR-9 mediated downregulation of HDAC5 promotes neurite development through activating MEF2C-GPM6A pathway.
Gu X, Fu C, Lin L, Liu S, Su X, Li A, Wu Q, Jia C, Zhang P, Chen L, Zhu X, Wang X
Journal of cellular physiology 2018 Jan;233(1):673-687
Journal of cellular physiology 2018 Jan;233(1):673-687
Long-term moderate exercise enhances specific proteins that constitute neurotrophin signaling pathway: A TMT-based quantitative proteomic analysis of rat plasma.
Wei Y, Fang CL, Liu SJ, Yang WQ, Wei LS, Lei XJ, Hu F, Huang HY, Li W, Chen W, Li LM, Long YS
Journal of proteomics 2018 Aug 15;185:39-50
Journal of proteomics 2018 Aug 15;185:39-50
MR-guided delivery of AAV2-BDNF into the entorhinal cortex of non-human primates.
Nagahara AH, Wilson BR, Ivasyk I, Kovacs I, Rawalji S, Bringas JR, Pivirotto PJ, Sebastian WS, Samaranch L, Bankiewicz KS, Tuszynski MH
Gene therapy 2018 Apr;25(2):104-114
Gene therapy 2018 Apr;25(2):104-114
Astrocytes mediated the nootropic and neurotrophic effects of Sarsasapogenin-AA13 via upregulating brain-derived neurotrophic factor.
Dong D, Mao Y, Huang C, Jiao Q, Pan H, Ma L, Wang R
American journal of translational research 2017;9(9):4015-4025
American journal of translational research 2017;9(9):4015-4025
Danshen-Chuanxiong-Honghua Ameliorates Cerebral Impairment and Improves Spatial Cognitive Deficits after Transient Focal Ischemia and Identification of Active Compounds.
Zhang X, Zheng W, Wang T, Ren P, Wang F, Ma X, Wang J, Huang X
Frontiers in pharmacology 2017;8:452
Frontiers in pharmacology 2017;8:452
Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ1-42-Induced Rat Model of Alzheimer's Disease.
Sheng C, Xu P, Zhou K, Deng D, Zhang C, Wang Z
BioMed research international 2017;2017:7464872
BioMed research international 2017;2017:7464872
Total abdominal irradiation exposure impairs cognitive function involving miR-34a-5p/BDNF axis.
Cui M, Xiao H, Li Y, Dong J, Luo D, Li H, Feng G, Wang H, Fan S
Biochimica et biophysica acta. Molecular basis of disease 2017 Sep;1863(9):2333-2341
Biochimica et biophysica acta. Molecular basis of disease 2017 Sep;1863(9):2333-2341
The Role of Endogenous Neurogenesis in Functional Recovery and Motor Map Reorganization Induced by Rehabilitative Therapy after Stroke in Rats.
Shiromoto T, Okabe N, Lu F, Maruyama-Nakamura E, Himi N, Narita K, Yagita Y, Kimura K, Miyamoto O
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017 Feb;26(2):260-272
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017 Feb;26(2):260-272
Human Umbilical Cord Mesenchymal Stem Cells Overexpressing Nerve Growth Factor Ameliorate Diabetic Cystopathy in Rats.
WenBo W, Fei Z, YiHeng D, Wei W, TingMang Y, WenHao Z, QianRu L, HaiTao L
Neurochemical research 2017 Dec;42(12):3537-3547
Neurochemical research 2017 Dec;42(12):3537-3547
Bone Marrow Stromal Cell Intraspinal Transplants Fail to Improve Motor Outcomes in a Severe Model of Spinal Cord Injury.
Brock JH, Graham L, Staufenberg E, Collyer E, Koffler J, Tuszynski MH
Journal of neurotrauma 2016 Jun 15;33(12):1103-14
Journal of neurotrauma 2016 Jun 15;33(12):1103-14
Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice.
Yang LP, Jiang FJ, Wu GS, Deng K, Wen M, Zhou X, Hong X, Zhu MX, Luo HR
PloS one 2015;10(8):e0136255
PloS one 2015;10(8):e0136255
SCM-198 Ameliorates Cognitive Deficits, Promotes Neuronal Survival and Enhances CREB/BDNF/TrkB Signaling without Affecting Aβ Burden in AβPP/PS1 Mice.
Hong ZY, Yu SS, Wang ZJ, Zhu YZ
International journal of molecular sciences 2015 Aug 7;16(8):18544-63
International journal of molecular sciences 2015 Aug 7;16(8):18544-63
Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition.
Wang N, Zhang Y, Wu L, Wang Y, Cao Y, He L, Li X, Zhao J
Neuropharmacology 2014 Apr;79:282-9
Neuropharmacology 2014 Apr;79:282-9
Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice.
Nagahara AH, Mateling M, Kovacs I, Wang L, Eggert S, Rockenstein E, Koo EH, Masliah E, Tuszynski MH
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Sep 25;33(39):15596-602
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Sep 25;33(39):15596-602
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- fetal human brain tissue were subjected to SDS PAGE followed by western blot with 25699-1-AP( BDNF Antibody) at dilution of 1:300
- Other comments
- WB
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemistry of paraffin-embedded human testis tissue slide using 25699-1-AP( BDNF Antibody) at dilution of 1:50 (under 10x lens)
- Other comments
- IHC
