Antibody data
- Antibody Data
- Antigen structure
- References [14]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 15520-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15520-1-AP, RRID:AB_2144799
- Product name
- MSH2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MSH2 antibody (Cat. #15520-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Lack of association of somatic CAG repeat expansion with striatal neurodegeneration in HD knock-in animal models.
Nrf2 overexpression increases risk of high tumor mutation burden in acute myeloid leukemia by inhibiting MSH2.
Clinicopathological and survival characteristic of mismatch repair status in ovarian clear cell carcinoma.
KALRN mutations promote antitumor immunity and immunotherapy response in cancer.
m6 A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.
Quantitative Proteomics Analysis Reveals Nuclear Perturbation in Human Glioma U87 Cells treated with Temozolomide.
Aberrantly expressed HORMAD1 disrupts nuclear localization of MCM8-MCM9 complex and compromises DNA mismatch repair in cancer cells.
Mismatch repair status as a beneficial predictor of fluorouracil-based adjuvant chemotherapy for pancreatic cancer.
A highly malignant case of neuroblastoma with substantial increase of single-nucleotide variants and normal mismatch repair system: A case report.
Significance of p53 expression in background endometrium in endometrial carcinoma.
Aberrant cytokeratin expression as a possible prognostic predictor in poorly differentiated colorectal carcinoma.
Ectopic expression of human MutS homologue 2 on renal carcinoma cells is induced by oxidative stress with interleukin-18 promotion via p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) signaling pathways.
Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-β in colorectal cells.
Estrogen stimulates the expression of mismatch repair gene hMLH1 in colonic epithelial cells.
Bai D, Yin P, Zhang Y, Sun F, Chen L, Lin L, Yan S, Li S, Li XJ
Human molecular genetics 2021 Jul 28;30(16):1497-1508
Human molecular genetics 2021 Jul 28;30(16):1497-1508
Nrf2 overexpression increases risk of high tumor mutation burden in acute myeloid leukemia by inhibiting MSH2.
Liu P, Ma D, Wang P, Pan C, Fang Q, Wang J
Cell death & disease 2021 Jan 5;12(1):20
Cell death & disease 2021 Jan 5;12(1):20
Clinicopathological and survival characteristic of mismatch repair status in ovarian clear cell carcinoma.
Zhu J, Ke G, Bi R, Wu X
Journal of surgical oncology 2020 Sep;122(3):538-546
Journal of surgical oncology 2020 Sep;122(3):538-546
KALRN mutations promote antitumor immunity and immunotherapy response in cancer.
Li M, Ma Y, Zhong Y, Liu Q, Chen C, Qiang L, Wang X
Journal for immunotherapy of cancer 2020 Oct;8(2)
Journal for immunotherapy of cancer 2020 Oct;8(2)
m6 A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.
Wang L, Hui H, Agrawal K, Kang Y, Li N, Tang R, Yuan J, Rana TM
The EMBO journal 2020 Oct 15;39(20):e104514
The EMBO journal 2020 Oct 15;39(20):e104514
Quantitative Proteomics Analysis Reveals Nuclear Perturbation in Human Glioma U87 Cells treated with Temozolomide.
Guo J, Yi GZ, Liu Z, Sun X, Yang R, Guo M, Li Y, Li K, Li K, Wang X, Song H, Qi S, Huang G, Liu Y
Cell biochemistry and function 2020 Mar;38(2):185-194
Cell biochemistry and function 2020 Mar;38(2):185-194
Aberrantly expressed HORMAD1 disrupts nuclear localization of MCM8-MCM9 complex and compromises DNA mismatch repair in cancer cells.
Liu K, Wang Y, Zhu Q, Li P, Chen J, Tang Z, Shen Y, Cheng X, Lu LY, Liu Y
Cell death & disease 2020 Jul 9;11(7):519
Cell death & disease 2020 Jul 9;11(7):519
Mismatch repair status as a beneficial predictor of fluorouracil-based adjuvant chemotherapy for pancreatic cancer.
Liang D, Shi S, Liang C, Meng Q, Zhang B, Ni Q, Xu J, Yu X
Surgery 2018 May;163(5):1080-1089
Surgery 2018 May;163(5):1080-1089
A highly malignant case of neuroblastoma with substantial increase of single-nucleotide variants and normal mismatch repair system: A case report.
Yuan LQ, Wang JH, Zhu K, Yang M, Gu WZ, Lai C, Li HM, Shu Q, Chen X
Medicine 2017 Dec;96(50):e8845
Medicine 2017 Dec;96(50):e8845
Significance of p53 expression in background endometrium in endometrial carcinoma.
Nguyen TT, Hachisuga T, Urabe R, Kurita T, Kagami S, Kawagoe T, Shimajiri S, Nabeshima K
Virchows Archiv : an international journal of pathology 2015 Jun;466(6):695-702
Virchows Archiv : an international journal of pathology 2015 Jun;466(6):695-702
Aberrant cytokeratin expression as a possible prognostic predictor in poorly differentiated colorectal carcinoma.
Yamagishi H, Imai Y, Okamura T, Fukuda K, Ono Y, Ban S, Inoue T, Ueda Y
Journal of gastroenterology and hepatology 2013 Dec;28(12):1815-22
Journal of gastroenterology and hepatology 2013 Dec;28(12):1815-22
Ectopic expression of human MutS homologue 2 on renal carcinoma cells is induced by oxidative stress with interleukin-18 promotion via p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) signaling pathways.
Mo C, Dai Y, Kang N, Cui L, He W
The Journal of biological chemistry 2012 Jun 1;287(23):19242-54
The Journal of biological chemistry 2012 Jun 1;287(23):19242-54
Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-β in colorectal cells.
He YQ, Sheng JQ, Ling XL, Fu L, Jin P, Yen L, Rao J
Experimental & molecular medicine 2012 Dec 31;44(12):723-32
Experimental & molecular medicine 2012 Dec 31;44(12):723-32
Estrogen stimulates the expression of mismatch repair gene hMLH1 in colonic epithelial cells.
Jin P, Lu XJ, Sheng JQ, Fu L, Meng XM, Wang X, Shi TP, Li SR, Rao J
Cancer prevention research (Philadelphia, Pa.) 2010 Aug;3(8):910-6
Cancer prevention research (Philadelphia, Pa.) 2010 Aug;3(8):910-6
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 15520-1-AP(MSH2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using MSH2 antibody 15520-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 15520-1-AP(MSH2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 15520-1-AP(MSH2 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue