APR00102G

antibody from Leading Biology

Targeting: MSH2 COCA1, HNPCC, HNPCC1

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

APR00102G

Provider

Leading Biology

Product name

MSH2 Antibody

Antibody type

Polyclonal

Description

DNA mismatch repair genes have been found to be associated with hereditary nonpolyposis colorectal cancer (HNPCC). Inherited mutations in the MSH2 were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability s μggests that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.