21112-1-AP

antibody from Proteintech Group

Targeting: DKK1 DKK-1, SK

Provider product page for 21112-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [21]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 21112-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#21112-1-AP, RRID:AB_10733097
Product name: DKK1 antibody
Antibody type: Polyclonal
Description: KD/KO validated DKK1 antibody (Cat. #21112-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

DKK1 protein structure - 21112-1-AP shown in red.

Submitted references Nomogram Incorporating the WNT/β-Catenin Signaling Pathway for Predicting the Survival of Cutaneous Melanoma.

Zhou YX, Wang X, Pang DQ, Wang YM, Bai J, Tian F, Han D, Shi S, Hu L
International journal of general medicine 2021;14:2751-2761

ZBTB38 suppresses prostate cancer cell proliferation and migration via directly promoting DKK1 expression.

Ding G, Lu W, Zhang Q, Li K, Zhou H, Wang F, Zhao C, Fan C, Wang J
Cell death & disease 2021 Oct 25;12(11):998

miR-29a-3p-dependent COL3A1 and COL5A1 expression reduction assists sulforaphane to inhibit gastric cancer progression.

Han S, Wang Z, Liu J, Wang HD, Yuan Q
Biochemical pharmacology 2021 Jun;188:114539

Fructus Ligustri Lucidi preserves bone quality through induction of canonical Wnt/β-catenin signaling pathway in ovariectomized rats.

Liu H, Guo Y, Zhu R, Wang L, Chen B, Tian Y, Li R, Ma R, Jia Q, Zhang H, Xia B, Li Y, Wang X, Zhu X, Zhang R, Brӧmme D, Gao S, Zhang D, Pei X
Phytotherapy research : PTR 2021 Jan;35(1):424-441

Transcriptome sequencing profiling identifies miRNA-331-3p as an osteoblast-specific miRNA in infected bone nonunion.

Zhang Y, Wang X, Huang X, Shen L, Zhang L, Shou D, Fan X
Bone 2021 Feb;143:115619

Hyperin Controls the Development and Therapy of Gastric Cancer via Regulating Wnt/β-Catenin Signaling.

Ping MH
Cancer management and research 2020;12:11773-11782

BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma.

Yu YP, Cai LC, Wang XY, Cheng SY, Zhang DM, Jian WG, Wang TD, Yang JK, Yang KB, Zhang C
Cancer science 2020 May;111(5):1555-1566

A1CF-promoted colony formation and proliferation of RCC depends on DKK1-MEK/ERK signal axis.

Ni D, Yi Q, Liu J, Hu Y, Lv T, Tan G, Liu Y, Xu L, Xia H, Zhou Q, Xie Y
Gene 2020 Mar 10;730:144299

LncRNA-LET inhibits cell growth of clear cell renal cell carcinoma by regulating miR-373-3p.

Ye Z, Duan J, Wang L, Ji Y, Qiao B
Cancer cell international 2019;19:311

UPLC-Q-TOF/MS characterization of efficacy substances on osteoblasts differentiation and function in rat serum after administration of Wang-Bi tablet.

Wang H, Guan Y, Wu R, Lv X, Shen X, Ye G
Biomedical chromatography : BMC 2019 Oct;33(10):e4628

Ginkgolide B and bilobalide promote the growth and increase β-catenin expression in hair follicle dermal papilla cells of American minks.

Zhang H, Shi Q, Nan W, Wang Y, Wang S, Yang F, Li G
BioFactors (Oxford, England) 2019 Nov;45(6):950-958

Distinctive role of ACVR1 in dentin formation: requirement for dentin thickness in molars and prevention of osteodentin formation in incisors of mice.

Zhang X, Shi C, Zhao H, Zhou Y, Hu Y, Yan G, Liu C, Li D, Hao X, Mishina Y, Liu Q, Sun H
Journal of molecular histology 2019 Feb;50(1):43-61

Rehmanniae Radix Preparata suppresses bone loss and increases bone strength through interfering with canonical Wnt/β-catenin signaling pathway in OVX rats.

Liu C, Wang L, Zhu R, Liu H, Ma R, Chen B, Li L, Guo Y, Jia Q, Shi S, Zhao D, Mo F, Zhao B, Niu J, Fu M, Orekhov AN, Brömme D, Gao S, Zhang D
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2019 Feb;30(2):491-505

Depleting PTOV1 sensitizes non-small cell lung cancer cells to chemotherapy through attenuating cancer stem cell traits.

Wu Z, Liu Z, Jiang X, Mi Z, Meng M, Wang H, Zhao J, Zheng B, Yuan Z
Journal of experimental & clinical cancer research : CR 2019 Aug 6;38(1):341

A1CF-Axin2 signal axis regulates apoptosis and migration in Wilms tumor-derived cells through Wnt/β-catenin pathway.

Ni D, Liu J, Hu Y, Liu Y, Gu Y, Zhou Q, Xie Y
In vitro cellular & developmental biology. Animal 2019 Apr;55(4):252-259

BPI-9016M, a c-Met inhibitor, suppresses tumor cell growth, migration and invasion of lung adenocarcinoma via miR203-DKK1.

Zhang P, Li S, Lv C, Si J, Xiong Y, Ding L, Ma Y, Yang Y
Theranostics 2018;8(21):5890-5902

Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model.

Wang Q, Zang W, Han L, Yang L, Ye S, Ouyang J, Zhang C, Bi Y, Zhang C, Bian H
Chinese medicine 2018;13:17

Radix Salviae miltiorrhizae improves bone microstructure and strength through Wnt/β-catenin and osteoprotegerin/receptor activator for nuclear factor-κB ligand/cathepsin K signaling in ovariectomized rats.

Liu H, Zhu R, Wang L, Liu C, Ma R, Qi B, Chen B, Li L, Guo Y, Shi S, Jia Q, Niu J, Zhao D, Mo F, Gao S, Zhang D
Phytotherapy research : PTR 2018 Dec;32(12):2487-2500

Apobec-1 complementation factor regulates cell migration and apoptosis through Dickkopf1 by acting on its 3' untranslated region in MCF7 cells.

Yan X, Li Q, Ni D, Xie Y, He Q, Wan Q, Liu Y, Lyu Z, Mao Z, Zhou Q
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jun;39(6):1010428317706218

MicroRNA-372 inhibits endometrial carcinoma development by targeting the expression of the Ras homolog gene family member C (RhoC).

Liu BL, Sun KX, Zong ZH, Chen S, Zhao Y
Oncotarget 2016 Feb 9;7(6):6649-64

Quantitative proteomic analysis reveals that anti-cancer effects of selenium-binding protein 1 in vivo are associated with metabolic pathways.

Ying Q, Ansong E, Diamond AM, Lu Z, Yang W, Bie X
PloS one 2015;10(5):e0126285

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human placenta tissue were subjected to SDS PAGE followed by western blot with 21112-1-AP(DKK1 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using DKK1 antibody 21112-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line