Antibody data

Product number
617002 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#617002, RRID:AB_315862
Product name
Purified anti-a-Adducin
Antibody type
Polyclonal
Antigen
Recombinant (partial)
Description
The α-adducin protein is a ubiquitously expressed cytoskeletal protein that binds with high affinity to Ca2+/calmodulin and acts as a substrate for protein kinases A and C. α-addducin is a 80-120 kD member of the aldolase class II family and adducin subfamily. This protein has three isoforms that interact as heterodimers α/β, and α/γ. The molecular weights for the various isoforms are α=120 kD; β=110kD; γ=80kD. This protein has been reported to promote the assembly of the spectrin-actin network. Polymorphisms in α-adducin are associated with cardiovascular disease and hypertension. α-adducin has been reported to interact with calmodulin. When phosphorylated by Rho-kinase, α-adducin can regulate membrane ruffling and cell motility. The Poly6170 antibody has been shown to be useful for Western blotting of mouse and human α-adducin protein.
Reactivity
Human, Mouse
Host
Rabbit
Conjugate
Unconjugated
Vial size
200 µl
Storage
Upon receipt, store frozen at -20° C.
ADD1 protein structure - 617002 shown in red.