CABT-L1796

antibody from Creative Diagnostics

Targeting: MMP14 MT1-MMP

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-L1796

Provider

Creative Diagnostics

Product name

Rabbit Anti-Human MMP14 polyclonal antibody

Antibody type

Polyclonal

Description

MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of the matrix metalloproteinase family, ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively, contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT1-MMP gets activated through the membrane plasmin cascade. It binds to TIMP-2 first and then to MMP-2 forming a trimer. It cleaves the pro-MMP-2 to its active form.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Storage

2-8°C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date.