11-3014-25

antibody from ABEOMICS Inc.
Targeting: OTUD5 DKFZp761A052, DUBA
Provider product page for 11-3014-25

Antibody data

Product number
11-3014-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-DUBA Antibody
Antibody type
Polyclonal
Description
DUBA belongs to a subfamily of 14 DUBs characterized by an OTU (Ovarian Tumor) domain. This protein suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. DUBA forms a direct complex with p53 and controls level of ubiquitination. The function of DUBA is required to allow the rapid activation of p53-dependent transcription and a p53-dependent apoptosis in response to DNA damage stress.
Reactivity
Human, Mouse
Host
Rabbit
Antigen sequence
A partial length recombinant DUBA p
rotein (amino acids 300-520) was us
ed as the immunogen for this antibo
dy.
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
OTUD5 protein structure - 11-3014-25 shown in red.