BS4052

antibody from Bioworld Technology, Inc
Targeting: PLA2G4A cPLA2-alpha, PLA2G4
Provider product page for BS4052
Western blot
Immunohistochemistry

Antibody data

Product number
BS4052 - Provider product page
Provider
Bioworld Technology, Inc
Product name
cPLA2 (phospho S505) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human cPLA2 around the phosphorylation site of Serine 505.
Description
Phospholipase A2s (PLA2s) constitute a family of esterases that hydrolyze the sn-2-acyl ester bond in glycerophospholipid molecules. These enzymes are generally calcium-dependent and have been found both intra- and extracellularly. By hydrolyzing the sn-2 bond in glycerophospholipids, PLA2s release fatty acids. One such fatty acid, arachidonic acid, generates the substrates for the initiation of the arachidonic acid cascade that produces various eicosanoids (i.e. prostaglandins, leukotrienes and thromboxanes), many of which are potent mediators of inflammation. PLA2s include both the relatively low molecular weight type I and type II enzymes and the form known as cytoplasmic PLA2 (cPLA2). cPLA2 is present in the cytosol of various cells and tissues including platelets, macrophages and monoblasts; and preferentially hydrolyzes the sn-2 position of phospholipid molecules, releasing free arachidonate.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PLA2G4A protein structure - BS4052 shown in red.