abx030684

antibody from Abbexa

Targeting: POLR1A DKFZP586M0122, FLJ21915, RPA1, RPA190, RPO1-4

No application information provided.

Antibody Data

Product number

abx030684

Provider

Abbexa

Product name

RNA Polymerase I Subunit A (POLR1A) Antibody

Antibody type

Polyclonal

Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

80 µl

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.