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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [44]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
- Other assay [1]
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- Product number
- MA5-12207 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- TIMP2 Monoclonal Antibody (3A4)
- Antibody type
- Monoclonal
- Antigen
- Synthetic peptide
- Description
- MA5-12207 targets TIMP-2 in IHC (P) and WB applications and shows reactivity with Bovine, Guinea Pig, Human, mouse, Rabbit, and Rat samples.
- Antibody clone number
- 3A4
- Concentration
- 0.2 mg/mL
Submitted references Lactobacillus casei Strain Shirota Enhances the In Vitro Antiproliferative Effect of Geniposide in Human Oral Squamous Carcinoma HSC-3 Cells.
Mechanisms Underlying Increased TIMP2 and IGFBP7 Urinary Excretion in Experimental AKI.
Interplay Between MMP-9 and TIMP-2 Regulates Ameloblastoma Behavior and Tooth Morphogenesis.
Expression and Clinical Significance of Metalloproteases and Their Inhibitors by Endothelial Cells From Invasive Breast Carcinomas.
Expression of matrix metalloproteinases and their inhibitors in different immunohistochemical-based molecular subtypes of breast cancer.
Immunoexpression of matrix metalloproteinases and their inhibitors in different areas of oral squamous cell carcinoma.
Comparative study of the immunohistochemical expression of tissue inhibitors of metalloproteinases 1 and 2 between clearly invasive carcinomas and "in situ" trophoblast invasion.
A novel model of intimal hyperplasia with graded hypoosmotic damage.
Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer.
Huangqi decoction inhibits apoptosis and fibrosis, but promotes Kupffer cell activation in dimethylnitrosamine-induced rat liver fibrosis.
Expression of matrix metalloproteinases and their inhibitors in squamous cell carcinoma of the tonsil and their clinical significance.
Differential immunohistochemical expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in cow uteri with adenomyosis during follicular phase.
Significant relation of tissue inhibitor of matrix metalloproteinase-2 and its combination with matrix metalloproteinase-2 to survival of patients with cancer of uterine cervix.
Semi-quantitative expression of tissue inhibitor of matrix metalloproteinase-2 in cancer of uterine cervix.
Expression of metalloproteases and their inhibitors by tumor and stromal cells in ductal carcinoma in situ of the breast and their relationship with microinvasive events.
Study of matrix metalloproteinases and their inhibitors in prostate cancer.
Expression of metalloproteases and their inhibitors in different histological types of breast cancer.
Immunohistochemical study of matrix metalloproteinases and their inhibitors in pure and mixed invasive and in situ ductal carcinomas of the breast.
Expression of metalloproteases and their inhibitors in primary tumors and in local recurrences after mastectomy for breast cancer.
Hypoxia promotes metastasis in human gastric cancer by up-regulating the 67-kDa laminin receptor.
The effects of interferon alpha2b on chemically-induced peritoneal fibrosis and on peritoneal tissue MMP-2 and TIMP-2 levels in rats.
The effects of interferon alpha2b on chemically-induced peritoneal fibrosis and on peritoneal tissue MMP-2 and TIMP-2 levels in rats.
Atorvastatin causes regression of endometriotic implants in a rat model.
Metformin regresses endometriotic implants in rats by improving implant levels of superoxide dismutase, vascular endothelial growth factor, tissue inhibitor of metalloproteinase-2, and matrix metalloproteinase-9.
Inhibition of transforming growth factor beta signaling by halofuginone as a modality for pancreas fibrosis prevention.
Comparative analysis and clinical value of the expression of metalloproteases and their inhibitors by intratumor stromal fibroblasts and those at the invasive front of breast carcinomas.
Menstrual activity of matrix metalloproteinases is decreased in endometrium regenerating after thermal ablation.
Gelatinase B expression as a prognostic factor in patients with stage II/III rectal carcinoma treated by postoperative adjuvant therapy.
Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2.
Overexpression of matrix metalloproteinases and their inhibitors in mononuclear inflammatory cells in breast cancer correlates with metastasis-relapse.
Connective tissue growth factor increases matrix metalloproteinase-2 and suppresses tissue inhibitor of matrix metalloproteinase-2 production by cultured renal interstitial fibroblasts.
Matrix metalloproteinases and their inhibitors in the chamber angle of normal eyes and patients with primary open-angle glaucoma and exfoliation glaucoma.
Study of matrix metalloproteinases and their inhibitors in breast cancer.
Effects of autologous stem cells on immunohistochemical patterns and gene expression of metalloproteinases and their tissue inhibitors in doxorubicin cardiomyopathy in a rabbit model.
Matrix metalloproteinase-9 expression correlated with tumor response in patients with locally advanced rectal cancer undergoing preoperative chemoradiotherapy.
EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma.
Distribution and expression of tissue inhibitors of metalloproteinase in dorsal root entry zone and dorsal column after dorsal root injury.
The distribution of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the lungs of congenital diaphragmatic hernia patients and age-matched controls.
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases during normal human pulmonary development.
Expression of cyclooxygenase-2 in human breast cancer: relationship with HER-2/neu and other clinicopathological prognostic factors.
The regulation of angiogenesis in neuroblastoma.
The regulation of angiogenesis in neuroblastoma.
Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformations.
Systemic arterial expression of matrix metalloproteinases 2 and 9 in acute Kawasaki disease.
Qian Y, Song JL, Sun P, Yi R, Liu H, Feng X, Park KY, Zhao X
Molecules (Basel, Switzerland) 2018 May 3;23(5)
Molecules (Basel, Switzerland) 2018 May 3;23(5)
Mechanisms Underlying Increased TIMP2 and IGFBP7 Urinary Excretion in Experimental AKI.
Johnson ACM, Zager RA
Journal of the American Society of Nephrology : JASN 2018 Aug;29(8):2157-2167
Journal of the American Society of Nephrology : JASN 2018 Aug;29(8):2157-2167
Interplay Between MMP-9 and TIMP-2 Regulates Ameloblastoma Behavior and Tooth Morphogenesis.
Nunia K, Urs AB, Kumar P
Applied immunohistochemistry & molecular morphology : AIMM 2016 May-Jun;24(5):364-72
Applied immunohistochemistry & molecular morphology : AIMM 2016 May-Jun;24(5):364-72
Expression and Clinical Significance of Metalloproteases and Their Inhibitors by Endothelial Cells From Invasive Breast Carcinomas.
Cid S, Eiro N, González LO, Beridze N, Vazquez J, Vizoso FJ
Clinical breast cancer 2016 Aug;16(4):e83-91
Clinical breast cancer 2016 Aug;16(4):e83-91
Expression of matrix metalloproteinases and their inhibitors in different immunohistochemical-based molecular subtypes of breast cancer.
Kim GE, Lee JS, Choi YD, Lee KH, Lee JH, Nam JH, Choi C, Kim SS, Park MH, Yoon JH, Kweon SS
BMC cancer 2014 Dec 16;14:959
BMC cancer 2014 Dec 16;14:959
Immunoexpression of matrix metalloproteinases and their inhibitors in different areas of oral squamous cell carcinoma.
Suarez-Roa ML, Asbun-Bojalil J, Ruiz-Godoy LM, Meneses-García AA
Australian dental journal 2012 Sep;57(3):300-7
Australian dental journal 2012 Sep;57(3):300-7
Comparative study of the immunohistochemical expression of tissue inhibitors of metalloproteinases 1 and 2 between clearly invasive carcinomas and "in situ" trophoblast invasion.
Dimo B, Ioannidis I, Karameris A, Vilaras G, Tzoumakari P, Nonni A, Patsouris E, Lazaris AC
Medical oncology (Northwood, London, England) 2012 Sep;29(3):2270-5
Medical oncology (Northwood, London, England) 2012 Sep;29(3):2270-5
A novel model of intimal hyperplasia with graded hypoosmotic damage.
Song M, Shen HT, Cui JJ, Zhou XG, Zhong X, Peng CH, Liu HY, Tian Y
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2012 Nov-Dec;21(6):490-8
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2012 Nov-Dec;21(6):490-8
Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer.
Brun JL, Cortez A, Lesieur B, Uzan S, Rouzier R, Daraï E
Oncology reports 2012 Apr;27(4):1049-57
Oncology reports 2012 Apr;27(4):1049-57
Huangqi decoction inhibits apoptosis and fibrosis, but promotes Kupffer cell activation in dimethylnitrosamine-induced rat liver fibrosis.
Liu C, Wang G, Chen G, Mu Y, Zhang L, Hu X, Sun M, Liu C, Liu P
BMC complementary and alternative medicine 2012 Apr 24;12:51
BMC complementary and alternative medicine 2012 Apr 24;12:51
Expression of matrix metalloproteinases and their inhibitors in squamous cell carcinoma of the tonsil and their clinical significance.
Lee SY, Park SY, Kim SH, Choi EC
Clinical and experimental otorhinolaryngology 2011 Jun;4(2):88-94
Clinical and experimental otorhinolaryngology 2011 Jun;4(2):88-94
Differential immunohistochemical expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in cow uteri with adenomyosis during follicular phase.
Moreira L, de Carvalho EC, Caldas-Bussiere MC
Veterinary research communications 2011 Jun;35(5):261-9
Veterinary research communications 2011 Jun;35(5):261-9
Significant relation of tissue inhibitor of matrix metalloproteinase-2 and its combination with matrix metalloproteinase-2 to survival of patients with cancer of uterine cervix.
Wang PH, Ko JL, Yang SF, Tsai HT, Tee YT, Han CP, Lin LY, Chen SC, Shih YT
Reproductive sciences (Thousand Oaks, Calif.) 2011 Aug;18(8):798-808
Reproductive sciences (Thousand Oaks, Calif.) 2011 Aug;18(8):798-808
Semi-quantitative expression of tissue inhibitor of matrix metalloproteinase-2 in cancer of uterine cervix.
Wu YC, Wang PH, Tsai A, Yang SF, Chen SC
Journal of surgical oncology 2011 Aug 1;104(2):210-5
Journal of surgical oncology 2011 Aug 1;104(2):210-5
Expression of metalloproteases and their inhibitors by tumor and stromal cells in ductal carcinoma in situ of the breast and their relationship with microinvasive events.
González LO, González-Reyes S, Junquera S, Marín L, González L, Del Casar JM, González JM, Vizoso F
Journal of cancer research and clinical oncology 2010 Sep;136(9):1313-21
Journal of cancer research and clinical oncology 2010 Sep;136(9):1313-21
Study of matrix metalloproteinases and their inhibitors in prostate cancer.
Escaff S, Fernández JM, González LO, Suárez A, González-Reyes S, González JM, Vizoso FJ
British journal of cancer 2010 Mar 2;102(5):922-9
British journal of cancer 2010 Mar 2;102(5):922-9
Expression of metalloproteases and their inhibitors in different histological types of breast cancer.
Del Casar JM, González-Reyes S, González LO, González JM, Junquera S, Bongera M, García MF, Andicoechea A, Serra C, Vizoso FJ
Journal of cancer research and clinical oncology 2010 Jun;136(6):811-9
Journal of cancer research and clinical oncology 2010 Jun;136(6):811-9
Immunohistochemical study of matrix metalloproteinases and their inhibitors in pure and mixed invasive and in situ ductal carcinomas of the breast.
Gonzalez LO, Junquera S, del Casar JM, González L, Marín L, González-Reyes S, Andicoechea A, González-Fernández R, González JM, Pérez-Fernández R, Vizoso FJ
Human pathology 2010 Jul;41(7):980-9
Human pathology 2010 Jul;41(7):980-9
Expression of metalloproteases and their inhibitors in primary tumors and in local recurrences after mastectomy for breast cancer.
del Casar JM, Carreño G, González LO, Junquera S, González-Reyes S, González JM, Bongera M, Merino AM, Vizoso FJ
Journal of cancer research and clinical oncology 2010 Jul;136(7):1049-58
Journal of cancer research and clinical oncology 2010 Jul;136(7):1049-58
Hypoxia promotes metastasis in human gastric cancer by up-regulating the 67-kDa laminin receptor.
Liu L, Sun L, Zhao P, Yao L, Jin H, Liang S, Wang Y, Zhang D, Pang Y, Shi Y, Chai N, Zhang H, Zhang H
Cancer science 2010 Jul;101(7):1653-60
Cancer science 2010 Jul;101(7):1653-60
The effects of interferon alpha2b on chemically-induced peritoneal fibrosis and on peritoneal tissue MMP-2 and TIMP-2 levels in rats.
Ucar E, Borazan A, Semerci E, Binici DN, Yaldiz M, Aysal A, Altug E, Kuvandik C, Huzmeli C, Yetim T, Canda S
The Journal of international medical research 2010 Jan-Feb;38(1):187-94
The Journal of international medical research 2010 Jan-Feb;38(1):187-94
The effects of interferon alpha2b on chemically-induced peritoneal fibrosis and on peritoneal tissue MMP-2 and TIMP-2 levels in rats.
Ucar E, Borazan A, Semerci E, Binici DN, Yaldiz M, Aysal A, Altug E, Kuvandik C, Huzmeli C, Yetim T, Canda S
The Journal of international medical research 2010 Jan-Feb;38(1):187-94
The Journal of international medical research 2010 Jan-Feb;38(1):187-94
Atorvastatin causes regression of endometriotic implants in a rat model.
Yilmaz B, Ozat M, Kilic S, Gungor T, Aksoy Y, Lordlar N, Sut N, Aksakal O
Reproductive biomedicine online 2010 Feb;20(2):291-9
Reproductive biomedicine online 2010 Feb;20(2):291-9
Metformin regresses endometriotic implants in rats by improving implant levels of superoxide dismutase, vascular endothelial growth factor, tissue inhibitor of metalloproteinase-2, and matrix metalloproteinase-9.
Yilmaz B, Sucak A, Kilic S, Aksakal O, Aksoy Y, Lortlar N, Sut N, Gungor T
American journal of obstetrics and gynecology 2010 Apr;202(4):368.e1-8
American journal of obstetrics and gynecology 2010 Apr;202(4):368.e1-8
Inhibition of transforming growth factor beta signaling by halofuginone as a modality for pancreas fibrosis prevention.
Zion O, Genin O, Kawada N, Yoshizato K, Roffe S, Nagler A, Iovanna JL, Halevy O, Pines M
Pancreas 2009 May;38(4):427-35
Pancreas 2009 May;38(4):427-35
Comparative analysis and clinical value of the expression of metalloproteases and their inhibitors by intratumor stromal fibroblasts and those at the invasive front of breast carcinomas.
Del Casar JM, González LO, Alvarez E, Junquera S, Marín L, González L, Bongera M, Vázquez J, Vizoso FJ
Breast cancer research and treatment 2009 Jul;116(1):39-52
Breast cancer research and treatment 2009 Jul;116(1):39-52
Menstrual activity of matrix metalloproteinases is decreased in endometrium regenerating after thermal ablation.
Brun JL, Galant C, Delvaux D, Lemoine P, Henriet P, Courtoy PJ, Marbaix E
Human reproduction (Oxford, England) 2009 Feb;24(2):333-40
Human reproduction (Oxford, England) 2009 Feb;24(2):333-40
Gelatinase B expression as a prognostic factor in patients with stage II/III rectal carcinoma treated by postoperative adjuvant therapy.
Unsal D, Akyurek N, Uner A, Erpolat OP, Han U, Akmansu M, Mentes BB, Dursun A
American journal of clinical oncology 2008 Feb;31(1):55-63
American journal of clinical oncology 2008 Feb;31(1):55-63
Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2.
Brun JL, Cortez A, Commo F, Uzan S, Rouzier R, Daraï E
International journal of oncology 2008 Dec;33(6):1239-46
International journal of oncology 2008 Dec;33(6):1239-46
Overexpression of matrix metalloproteinases and their inhibitors in mononuclear inflammatory cells in breast cancer correlates with metastasis-relapse.
González LO, Pidal I, Junquera S, Corte MD, Vázquez J, Rodríguez JC, Lamelas ML, Merino AM, García-Muñiz JL, Vizoso FJ
British journal of cancer 2007 Oct 8;97(7):957-63
British journal of cancer 2007 Oct 8;97(7):957-63
Connective tissue growth factor increases matrix metalloproteinase-2 and suppresses tissue inhibitor of matrix metalloproteinase-2 production by cultured renal interstitial fibroblasts.
Yang M, Huang H, Li J, Huang W, Wang H
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2007 Nov-Dec;15(6):817-24
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2007 Nov-Dec;15(6):817-24
Matrix metalloproteinases and their inhibitors in the chamber angle of normal eyes and patients with primary open-angle glaucoma and exfoliation glaucoma.
Rönkkö S, Rekonen P, Kaarniranta K, Puustjärvi T, Teräsvirta M, Uusitalo H
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2007 May;245(5):697-704
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2007 May;245(5):697-704
Study of matrix metalloproteinases and their inhibitors in breast cancer.
Vizoso FJ, González LO, Corte MD, Rodríguez JC, Vázquez J, Lamelas ML, Junquera S, Merino AM, García-Muñiz JL
British journal of cancer 2007 Mar 26;96(6):903-11
British journal of cancer 2007 Mar 26;96(6):903-11
Effects of autologous stem cells on immunohistochemical patterns and gene expression of metalloproteinases and their tissue inhibitors in doxorubicin cardiomyopathy in a rabbit model.
Aupperle H, Garbade J, Schubert A, Barten M, Dhein S, Schoon HA, Mohr FW
Veterinary pathology 2007 Jul;44(4):494-503
Veterinary pathology 2007 Jul;44(4):494-503
Matrix metalloproteinase-9 expression correlated with tumor response in patients with locally advanced rectal cancer undergoing preoperative chemoradiotherapy.
Unsal Kilic D, Uner A, Akyurek N, Erpolat P, Dursun A, Pak Y
International journal of radiation oncology, biology, physics 2007 Jan 1;67(1):196-203
International journal of radiation oncology, biology, physics 2007 Jan 1;67(1):196-203
EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma.
Sier CF, Zuidwijk K, Zijlmans HJ, Hanemaaijer R, Mulder-Stapel AA, Prins FA, Dreef EJ, Kenter GG, Fleuren GJ, Gorter A
International journal of cancer 2006 Jun 15;118(12):2991-8
International journal of cancer 2006 Jun 15;118(12):2991-8
Distribution and expression of tissue inhibitors of metalloproteinase in dorsal root entry zone and dorsal column after dorsal root injury.
Zhang X, Bo X, Anderson PN, Lieberman AR, Zhang Y
Journal of neuroscience research 2006 Aug 1;84(2):278-90
Journal of neuroscience research 2006 Aug 1;84(2):278-90
The distribution of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the lungs of congenital diaphragmatic hernia patients and age-matched controls.
Masumoto K, de Rooij JD, Suita S, Rottier R, Tibboel D, de Krijger RR
Histopathology 2006 Apr;48(5):588-95
Histopathology 2006 Apr;48(5):588-95
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases during normal human pulmonary development.
Masumoto K, de Rooij JD, Suita S, Rottier R, Tibboel D, de Krijger RR
Histopathology 2005 Oct;47(4):410-9
Histopathology 2005 Oct;47(4):410-9
Expression of cyclooxygenase-2 in human breast cancer: relationship with HER-2/neu and other clinicopathological prognostic factors.
Nam E, Lee SN, Im SA, Kim DY, Lee KE, Sung SH
Cancer research and treatment 2005 Jun;37(3):165-70
Cancer research and treatment 2005 Jun;37(3):165-70
The regulation of angiogenesis in neuroblastoma.
Chlenski A, Liu S, Cohn SL
Cancer letters 2003 Jul 18;197(1-2):47-52
Cancer letters 2003 Jul 18;197(1-2):47-52
The regulation of angiogenesis in neuroblastoma.
Chlenski A, Liu S, Cohn SL
Cancer letters 2003 Jul 18;197(1-2):47-52
Cancer letters 2003 Jul 18;197(1-2):47-52
Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformations.
Hashimoto T, Wen G, Lawton MT, Boudreau NJ, Bollen AW, Yang GY, Barbaro NM, Higashida RT, Dowd CF, Halbach VV, Young WL, University of California, San Francisco BAVM Study Group
Stroke 2003 Apr;34(4):925-31
Stroke 2003 Apr;34(4):925-31
Systemic arterial expression of matrix metalloproteinases 2 and 9 in acute Kawasaki disease.
Gavin PJ, Crawford SE, Shulman ST, Garcia FL, Rowley AH
Arteriosclerosis, thrombosis, and vascular biology 2003 Apr 1;23(4):576-81
Arteriosclerosis, thrombosis, and vascular biology 2003 Apr 1;23(4):576-81
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot of TIMP-2 using TIMP-2 Monoclonal Antibody (Product # MA5-12207) on HFL-1+TPA med Cells.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Formalin-fixed, paraffin-embedded human pancreatic tumor stained with TIMP-2 antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
