orb1730542

antibody from Biorbyt

Targeting: PMS2 H_DJ0042M02.9, HNPCC4, MLH4, PMSL2

Western blot

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

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Validation data

Product number: orb1730542 - Provider product page
Provider: Biorbyt
Product name: PMS2 Antibody
Antibody type: Polyclonal
Description: Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Vial size: 100 μl
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

PMS2 protein structure - orb1730542 shown in red.