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Western blot
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [2]
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- Validations
- Flow cytometry [1]
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- Product number
- AF906 - Provider product page
- Provider
- R&D Systems
- Product name
- Human Common beta Chain Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects recombinant human (rh) Common beta Chain in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) GM-CSF R alpha , rhG-CSF R and rhM-CSF R is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
P32927- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Three lysine residues in the common β chain of the interleukin-5 receptor are required for Janus kinase (JAK)-dependent receptor ubiquitination, endocytosis, and signaling.
Separate endocytic pathways regulate IL-5 receptor internalization and signaling.
Lei JT, Mazumdar T, Martinez-Moczygemba M
The Journal of biological chemistry 2011 Nov 18;286(46):40091-103
The Journal of biological chemistry 2011 Nov 18;286(46):40091-103
Separate endocytic pathways regulate IL-5 receptor internalization and signaling.
Lei JT, Martinez-Moczygemba M
Journal of leukocyte biology 2008 Aug;84(2):499-509
Journal of leukocyte biology 2008 Aug;84(2):499-509
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Supportive validation
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- R&D Systems (provider)
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- Experimental details
- Detection of Common beta Chain in Human PBL by Flow Cytometry. Human peripheral blood lymphocytes were stained with Goat Anti-Human Common beta Chain Antigen Affinity-purified Polyclonal Antibody (Catalog # AF906, filled histogram) or control antibody (Catalog # AB-108-C, open histogram), followed by Fluorescein-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0109).
