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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [18]
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- Validations
- Immunohistochemistry [1]
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- Product number
- sc-713 - Provider product page
- Provider
- Santa Cruz Biotechnology
- Proper citation
- Santa Cruz Biotechnology Cat#sc-713, RRID:AB_671792
- Product name
- Anti-IGF1R
- Antibody type
- Polyclonal (Antigen purified)
- Antigen
- Synthetic peptide
- Reactivity
- Human
- Host
- Rabbit
Submitted references A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors.
Green tea epigallocatechin gallate exhibits anticancer effect in human pancreatic carcinoma cells via the inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor.
Locking Src/Abl Tyrosine Kinase Activities Regulate Cell Differentiation and Invasion of Human Cervical Cancer Cells Expressing E6/E7 Oncoproteins of High-Risk HPV.
Targeted deletion of somatotroph insulin-like growth factor-I signaling in a cell-specific knockout mouse model.
Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription.
MUC1 regulates nuclear localization and function of the epidermal growth factor receptor.
Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells.
Myoferlin is required for insulin-like growth factor response and muscle growth.
Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression.
Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling.
Platelet-derived growth factor receptor expression and activation in choroid plexus tumors.
Targeting of the protein interaction site between FAK and IGF-1R.
Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation.
BMS-536924 reverses IGF-IR-induced transformation of mammary epithelial cells and causes growth inhibition and polarization of MCF7 cells.
Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin.
Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail.
EGF-mediated regulation of IGFBP-3 determines esophageal epithelial cellular response to IGF-I.
A novel approach in the treatment of neuroendocrine gastrointestinal tumours. Targeting the epidermal growth factor receptor by gefitinib (ZD1839)
Lim KJ, Bisht S, Bar EE, Maitra A, Eberhart CG
Cancer biology & therapy 2011 Mar 1;11(5):464-73
Cancer biology & therapy 2011 Mar 1;11(5):464-73
Green tea epigallocatechin gallate exhibits anticancer effect in human pancreatic carcinoma cells via the inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor.
Vu HA, Beppu Y, Chi HT, Sasaki K, Yamamoto H, Xinh PT, Tanii T, Hara Y, Watanabe T, Sato Y, Ohdomari I
Journal of biomedicine & biotechnology 2010;2010:290516
Journal of biomedicine & biotechnology 2010;2010:290516
Locking Src/Abl Tyrosine Kinase Activities Regulate Cell Differentiation and Invasion of Human Cervical Cancer Cells Expressing E6/E7 Oncoproteins of High-Risk HPV.
Yasmeen A, Alachkar A, Dekhil H, Gambacorti-Passerini C, Al Moustafa AE
Journal of oncology 2010;2010
Journal of oncology 2010;2010
Targeted deletion of somatotroph insulin-like growth factor-I signaling in a cell-specific knockout mouse model.
Romero CJ, Ng Y, Luque RM, Kineman RD, Koch L, Bruning JC, Radovick S
Molecular endocrinology (Baltimore, Md.) 2010 May;24(5):1077-89
Molecular endocrinology (Baltimore, Md.) 2010 May;24(5):1077-89
Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription.
Boucher J, Tseng YH, Kahn CR
The Journal of biological chemistry 2010 May 28;285(22):17235-45
The Journal of biological chemistry 2010 May 28;285(22):17235-45
MUC1 regulates nuclear localization and function of the epidermal growth factor receptor.
Bitler BG, Goverdhan A, Schroeder JA
Journal of cell science 2010 May 15;123(Pt 10):1716-23
Journal of cell science 2010 May 15;123(Pt 10):1716-23
Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells.
Carver KC, Piazza TM, Schuler LA
The Journal of biological chemistry 2010 Mar 12;285(11):8003-12
The Journal of biological chemistry 2010 Mar 12;285(11):8003-12
Myoferlin is required for insulin-like growth factor response and muscle growth.
Demonbreun AR, Posey AD, Heretis K, Swaggart KA, Earley JU, Pytel P, McNally EM
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Apr;24(4):1284-95
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Apr;24(4):1284-95
Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression.
Cornu M, Modi H, Kawamori D, Kulkarni RN, Joffraud M, Thorens B
The Journal of biological chemistry 2010 Apr 2;285(14):10538-45
The Journal of biological chemistry 2010 Apr 2;285(14):10538-45
Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling.
Ma T, Zhao Y, Kwak YD, Yang Z, Thompson R, Luo Z, Xu H, Liao FF
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Sep 9;29(36):11226-36
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Sep 9;29(36):11226-36
Platelet-derived growth factor receptor expression and activation in choroid plexus tumors.
Koos B, Paulsson J, Jarvius M, Sanchez BC, Wrede B, Mertsch S, Jeibmann A, Kruse A, Peters O, Wolff JE, Galla HJ, Söderberg O, Paulus W, Ostman A, Hasselblatt M
The American journal of pathology 2009 Oct;175(4):1631-7
The American journal of pathology 2009 Oct;175(4):1631-7
Targeting of the protein interaction site between FAK and IGF-1R.
Zheng D, Kurenova E, Ucar D, Golubovskaya V, Magis A, Ostrov D, Cance WG, Hochwald SN
Biochemical and biophysical research communications 2009 Oct 16;388(2):301-5
Biochemical and biophysical research communications 2009 Oct 16;388(2):301-5
Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation.
Novosyadlyy R, Vijayakumar A, Lann D, Fierz Y, Kurshan N, LeRoith D
Oncogene 2009 Oct 1;28(39):3477-86
Oncogene 2009 Oct 1;28(39):3477-86
BMS-536924 reverses IGF-IR-induced transformation of mammary epithelial cells and causes growth inhibition and polarization of MCF7 cells.
Litzenburger BC, Kim HJ, Kuiatse I, Carboni JM, Attar RM, Gottardis MM, Fairchild CR, Lee AV
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Jan 1;15(1):226-37
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Jan 1;15(1):226-37
Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin.
Schaefer L, Tsalastra W, Babelova A, Baliova M, Minnerup J, Sorokin L, Gröne HJ, Reinhardt DP, Pfeilschifter J, Iozzo RV, Schaefer RM
The American journal of pathology 2007 Jan;170(1):301-15
The American journal of pathology 2007 Jan;170(1):301-15
Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail.
Kim HJ, Litzenburger BC, Cui X, Delgado DA, Grabiner BC, Lin X, Lewis MT, Gottardis MM, Wong TW, Attar RM, Carboni JM, Lee AV
Molecular and cellular biology 2007 Apr;27(8):3165-75
Molecular and cellular biology 2007 Apr;27(8):3165-75
EGF-mediated regulation of IGFBP-3 determines esophageal epithelial cellular response to IGF-I.
Takaoka M, Smith CE, Mashiba MK, Okawa T, Andl CD, El-Deiry WS, Nakagawa H
American journal of physiology. Gastrointestinal and liver physiology 2006 Feb;290(2):G404-16
American journal of physiology. Gastrointestinal and liver physiology 2006 Feb;290(2):G404-16
A novel approach in the treatment of neuroendocrine gastrointestinal tumours. Targeting the epidermal growth factor receptor by gefitinib (ZD1839)
M Höpfner, A P Sutter, B Gerst, M Zeitz, H Scherübl
British Journal of Cancer 2003 Oct;89(9):1766-1775
British Journal of Cancer 2003 Oct;89(9):1766-1775
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Supportive validation
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- Main image
- Experimental details
- Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells of tubules.
- Validation comment
- Staining pattern partly consistent with experimental and/or bioinformatic data.
